What is another term for type 1 hypersensitivity

A. Immune mediated

B. Immune Complex

C. Anaphylaxis

D. Cell Mediated

Which immunoglobulin is mainly associated with type 1 hypersensitivty

A. IgG

B. IgM

C. IgA

D. IgE

Anaphylactic reactions invlove

A. antigen binding to an antibody

B. Antigen contacting antibody that is bound to membrane Fc receptors

C. activation of complement

D. antibody-dependent cell mediated cytotoxicity

Atopic diseases are associated with the production of

A. IgA

B. IgE

C. IgD

D. IgG

An initial exposure to antigen results in the production of homocytotropic antibodies. These antibodies are

A. IgE and IgM

B. IgG and IgD

C. IgG1 and IgE

D. IgM and IgG

Antibodies are able to bind to the Fc receptors for IgE found on the surfaces of what cell types

A. basophils and neutrophils

B. neutrophils and mast cells

C. macrophages and lymphocytes

D. basophils and mast cells

Does sensitization injure cells

A. yes

B. No

Matching

A. Histamine

B. ECF-A

C. Leukotrienes

D. Platelet Activating Factor

E. neutral proteases

1. very potent vasoactive and spasmogenic agents

2. can cleave complement components and  thereby generate additional biologically active fragments that contribute to the mast cell degranulation

3. attracts eosinophils to the reactive site

4. causes platelet aggregation, release of histamine and bronchospasm prostaglandins: contributes to bronchospasm and mucus secretion

5. increases vascular permeability, vasodilation, bronchospasm and increased secretion of mucus

A---->5

B---->3

C---->1

D--->4

E---->2

Which type of asthma is more inclined to produce an anaphylactic reaction

A. intrinsic

B. extrinsic

What is the most common allergic disease following exposure to allergen leading to symtopms such as congestion, sneezing

A. allergic rhinitis

B. urticaria

C. asthma

D. allergic gastroenteritis

Congestion, sneezing, pruritis and lacrimation are produced by all except

A. dilation of blood vessels

B. reversible airway obstruction

C. edema

D. nerve irritation

Transient eruption characterized by erythematous and edematous swelling of mainly the subcutaneous tissues especially those of the face and the lips

A. urticaria

B. allergic rhinitis

C. allergic gastroenteritis

D. angioedema

Lesions present in urticaria usually

A. last a few days

B. fade within 24 hrs

C. disappear and reappear after a few days

D. last a few weeks

A reaction to an ingested allergen may take

A. mins to an hour

B. hours to a few days

C. a day

D. a few hours

Symptoms for allergic gastroenteritis

A. perioral erythema, lip swelling

B. swelling of the tongue and pharynx

C. nause and vomitting

D. B and C only

E. A,B and C

Anaphylaxis usually occurs following the ____administration of an allergen

A. oral

B. parenteral

C. Transdermal

D. rectal

Which group of symptoms appears within minutes after exposure to an allergen during an anaphylactic reaction

A. vomitting, abdominal cramps,itiching, urticaria

B. skin erythema, abdominal cramps and urticaria

C. skin erythema, itching, urticaria

D. vomiting, urticaria, skin erythema

All are drugs used to treat an anaphylactic reaction except

A. Theophylline

B. antihistamines

C. Epinephrine

D. corticosteroids

E. cromolyn sodium

Type 2 hypersensitivity is associated with which antibody(dies)

A. IgG

B. IgM and IgG

C. IgE

D. IgE and IgM

Once Ag and Ab bind to each other, they can be destroyed by all these mechanisms except

A. phagocytosis

B. complement activation

C. apoptosis

D. ADCC

A common group of antigens that forms complexes on the cell surface usually involving blood

A. haptens

B. hapthens

C. immunoglobulins

Match the cell type with the corresponding type 2 hypersensitivity response

A. RBC

B. GBM

C. PMN

D. Platelets

1. Thromboctopenia purpura

2. anemia

3. glomerulonephritis

4. agranulocytosis

A---->2

B--->3

C--->4

D--->1

Ag-Ab reactions during incompatible blood transfusions trigger a series of interactions between

A. complement and coagulation pathways

B. complement and phagocytosis

C. coagulation and phagocytosis

Increased rate of RBC destruction by antibodies and complement occurs in

A. Imcompatible Blood Transfusion reaction

B. Hemolytic Anemia

C. Erythroblastosis fetalis

Matching( an answer can be used more than once)

1. warm type anemia

2. cold type anemia

A. IgG

B. IgM9

C. extravascular hemolysis of the spleen

D. occurs at temps below 32 C

E. peripheral RBC agglutination

Ans 1---->A

2---->B

1---->C

2---->D

2---->D

Hemolytic disease of the new born results in damage to RBC by

A. anti D

B. anti G

C. complement

D. A and C

Hemolysis of RBCs cause an increase in the level of billirubin. What is the meaning of Kernicturus

A. increased billirubin in the blood

B. increased billirubin in the brain

C. increased billirubin in the lymphatic system

All are end results of erythroblastosis fetalis

A. toxic brain syndrome

B. heart failure

C. enlarged liver/spleen

D. hyropus fetalis

E. none of the above

This disorder has a low platelet count and the presence of magakaryocytes in the bone marrow

A. autoimmune thrombocytopenia purpura

B. glomerulonephritis

C. agranulocytosis

D. anemia

Cutaneous signs of thrombocytopenia purpura includes all except

A. petechiae

B. purpura

C. mucosal hemorrhage

D. fever

Treatment for hemolytic disease of the new born is phototherapy and a blood transfusion for the child. What does phototherapy do

A. degrade bilirubin

B. prevent further RBC hemolysis

C. decrease swelling