Term
|
Definition
| 3 sections, acinar cells, islets of Langerhans |
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Term
|
Definition
| secrete digestive juices, regulates blood glucose, other hormonal functions |
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Term
|
Definition
| hormonal & nervous regulation, hormonal controls: CCK, secretin |
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Term
|
Definition
| inflammation of pancreas, 2 types: acute, chronic |
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|
Term
| Pancreatitis common etiologies |
|
Definition
| gallstones/biliary tract disease, alcohol |
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|
Term
| Other pancreatitis etiologies |
|
Definition
| surgery/trauma, cystic fibrosis, certain mutations of CF gene, hypertriglyceridemia, penetrating duodenal ulcer, some medications, cancer, viral infection |
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|
Term
| Acute pancreatitis proposed pathophysiology |
|
Definition
| primary acinar cell injury/damage to pancreas/blockage of sphincter of Oddi -> retention of pancreatic enzymes -> premature activation of pancreatic enzymes -> recruitment of inflammatory cells -> autodigestion of pancreas/blood vessels/tissue -> pseudocyst development |
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Term
| Acute pancreatitis symptoms |
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Definition
| severe abdominal pain(intensified by eating), N/V, diarrhea(poss. steatorrhea), wt loss, hypotension, fever |
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|
Term
| Acute pancreatitis dx tests |
|
Definition
| MRI cholangiopancreatography, abdominial/chest xray, CT scan, ultrasound |
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|
Term
| Acute pancreatitis lab results |
|
Definition
| incresed serum amylase(>250U/L), lipase(>110U/L), & bilirubin, increased CRP, AST, ALT, & LDH, elevated WBC count & plasma glucose, hyperTG, hypoCa, hypoK, hypoMg, hypoalbuminemia |
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|
Term
| Acute Pancreatitis complications |
|
Definition
| sepsis/infection, pseudocysts, abscess, organ dysfunction, death |
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Term
| Severe acute pancreatitis nutrtional mgmt |
|
Definition
| >30kcal/kg (indirect calorimetry), protein: 1.5-2g/kg, low fat, easily digestible (TF/PN) |
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|
Term
| Potential nutrition therapies |
|
Definition
| arginine, glutamine, omega 3 fatty acids, probiotics, pro&prebiotics |
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|
Term
| Acute pancreatitis medical mgmt |
|
Definition
| analgesics, fluid resuscitation, H2 receptor antagonists, somatostatin, pancreatic enzyme replacement therapy |
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Term
|
Definition
| initiated by pancreatic injury: recruitment of macrophages -> stellate cell stimulation -> collagen formation -> fibrosis, alcoholism most common cause, progressive loss of pancreatic tissue & endo/exocrine function |
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|
Term
| Chronic pancreatitis symptoms |
|
Definition
| N/V, fatty stools, abdominal pain, wt loss |
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|
Term
| Chronic pancreatitis lab results |
|
Definition
| malabsorption of many nutrients, hypoCa, hypoK, hypoMg, hyperbilirubinemia |
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|
Term
| Chronic pancreatitis imaging tests |
|
Definition
| radiographs, CT scan, ERCP, endoscopic ultrasonography |
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|
Term
| Chronic pancreatitis function tests |
|
Definition
| OGTT, abnormal secretin-CCK, abnormal bentiromide test |
|
|
Term
| effects of chronic pancreatitis |
|
Definition
| maldigestion, malabsorption, diabetes |
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|
Term
| Chronic pancreatitis nutritional mgmt |
|
Definition
| increased kcal&nutrients, fat as tolerated, small frequent meals, B12, Mg, Ca, Zn supplement, no alcohol |
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|
Term
| Chronic pancreatitis medical mgmt |
|
Definition
| pain releivers, pancreatic enzyme replacement therapy, antacids, H2 receptor blockers, proton pump inhibitors |
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