Term
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Definition
| Found in soy proteins, wheat & corn flour, coffee & tea |
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Term
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Definition
| Red meat, seafood, poultry, pork, and dairy products, whole grains, vegetables, biliary and pancreatic secretions |
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Term
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Definition
| must be hydrolysed by proteases, nucleases, pepsin and HCl, |
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Term
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Definition
| Mainly in small intestine, both carrier-mediated (saturable) and passive (non-saturable), as dietary Zn increases fecal excretion increases and absoprtion decreases |
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Term
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Definition
| facilitate Zn movement into and out of cells, 2 types: ZnT family and Zip family |
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Term
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Definition
| control Zn efflux, puts Zn into portal circulation |
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Term
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Definition
| (Zinc and iron like transporters)control Zn influx, absorbs Zn from lumen |
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Term
| Acrodermatitis enteropathica (AE) |
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Definition
| disease of Zn malabsorption, Zn responsive inborn error of metabolism, usually affects infants |
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Term
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Definition
| dermatitis, impaired immunity, impaired wound healing, hair loss, annorexia, impaired taste acuity |
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Term
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Definition
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Term
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Definition
| transported in blood bound to albumin for utilization/storage |
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Term
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Definition
| 1.5-2.5 g (slightly less than iron), skeletal muscle holds the most |
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Term
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Definition
| Fecal (~90%) 1-5 mg/d, Urinary (~10%) responds to muscle catabolism |
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Term
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Definition
| Men-11 mg/d, women-8 mg/d, pregnant-11 mg/d, lactating-12 mg/d |
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Term
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Definition
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Term
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Definition
| deficiency is associated with decreased resistance to infectious diseases |
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Term
| Zinc/immunity possible mechanisms |
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Definition
| 1. damages epidermal cells, 2. harms epidermal lining of GI and pulmonary tracts, 3. interferes w/ cellular mediators of immunity |
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Term
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Definition
| no reliable indicator of Zn status |
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Term
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Definition
| catalytic, structural, regulatory |
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Term
| catalytic functions of zinc |
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Definition
| greater than 300 metalloenzymes identified, but no relationship between toxicity/deficiency and enzyme function |
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Term
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Definition
| 1st metalloenzyme discovered, regulates pH balance |
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Term
| zinc structural functions |
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Definition
| necessary for tertiary and quaternary protein structure, estimated that as much as 10% of human genome codes for zinc-binding proteins |
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Term
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Definition
| most common DNA bonding domain, binding to DNA inhibits/expresses target gene, 3 types: C4, C2H2, C3H1 |
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Term
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Definition
| Nuclear receptors, ex. Retinoic Acid Recptors (RAR), Vitamin D Receptors (VDR) |
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Term
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Definition
| most common family, ex. TFIIIA, c-Jun, p53 |
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Term
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Definition
| ex. tristetraprolin (TTP) |
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Term
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Definition
| Cu/Zn super-oxide dismutase, inducible nitric oxide synthetase, metallothienin |
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Term
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Definition
| low molecular wt cysteine rich binding proteins, bind up to 7 Zn atoms and other divalent cations |
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Term
| metallothienin proposed functions |
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Definition
| anitoxidant, heavy-metal detoxification, facilitator of zinc siganlling, Zn intestinal absorption, Zn storage, Zn trafficking |
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Term
| zinc regulatory functions |
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Definition
| activates MTF-1, binds to MT promoter to increase expression |
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Term
| zinc regulatory signaling molecule |
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Definition
| alters gene function or inhibits protein expression, mechanism is drawn from other secondary messengers |
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