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Human Physiology-Lecture 1
Cell and Genreal Physiology
41
Physiology
Graduate
02/07/2013

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Term

Transport Mechanism:

Passive Transport

Definition
No Energy; In favor of concentration gradient; Diffusion; Facilitated diffusion; Filtration; Osmosis
Term

Transport Mechanisms: 

Active Transport

Definition

Energy; Against concentration gradient; carrier;

Bulk transport-Exocytosis, Endocytosis, Phagocytosis, Pinocytosis 

Term
Endocytosis
Definition
the transport of solid matter or liquid into a cell by means of acoated vacuole or vesicle; active transport
Term
Exocytosis
Definition
he transport of material out of a cell by means of a sac or vesiclethat first engulfs the material and then is extruded through anopening in the cell membrane; active transport
Term
Phagocytosis
Definition
the ingestion of a smaller cell or cell fragment, amicroorganism, or foreign particles by means of the local infolding ofa cell's membrane and the protrusion of its cytoplasm around the folduntil the material has been surrounded and engulfed by closure of themembrane and formation of a vacuole: characteristic of amebas andsome types of white blood cells; active transport
Term
Pinocytosis
Definition
 the transport of fluid into a cell by means of local infoldings by thecell membrane so that a tiny vesicle or sac forms around eachdroplet, which is then taken into the interior of the cytoplasm; active transport
Term
Simple Diffusion
Definition
In favor of concentration gradient based on kinetic energy of molecules, depending on concentration; through membrane openings or intermolecular spaces
Term
Fick's Law of Diffusion
Definition
V= (C*A*AS*T)/R
Term
Fick's Law of Diffusion: V
Definition
Net rate of diffusion
Term
Fick's Law of Diffusion: C
Definition
Diffusion Coefficient
Term
Fick's Law of Diffusion: A
Definition
Cross Sectional Area
Term
Fick's Law of Diffusion: AS
Definition
S1-S2 Concentration Gradient
Term
Fick's Law of Diffusion: T
Definition
Temperature
Term
Fick's Law of Diffusion: R
Definition
Molecule Radius
Term
Facilitated Diffusion
Definition
the movement of molecules across a selectively permeable membane  with the aid of specialized transport proteins embedded within the membrane; passive transport
Term
Simple Diffusion
Definition
the spontaneous movement of molecules across a biological membrane's lipid bilayer from an area of higher concentration to an area of low concentration; passive transport
Term
Filtration
Definition
movement of solvent and solute due to hydrostatic pressure gradient; passive transport
Term
Bulk transport
Definition
(Vesicular); the uptake by or extrusion from a cell of fluid or particles, accomplished by invagination and vacuole formation (uptake) or by evagination (extrusion); it includes endocytosis, phagocytosis, pinocytosis, and exocytosis.
Term
Osmotic Pressure
Definition
The exact amount of pressue required to stop osmosis; depends on number of particules or concentration of the solute
Term
Osmoles
Definition
equivalent to 1 gram of molecular weight of undissociated solute; .001 osmoles in 1kg=osmolality of 1milliosmole/kg
Term
Normal Osmolality of extracellular and intracellular fluids
Definition
300 milliosmoles/kg
Term

At normal body temp (37 degrees Celcius):

1osmole/liter=_______mmHg

Definition
19300 mmHg
Term

Osmotic Pressure in the solution is 

1 milliosmoles/L=_____mmHg

 

Definition
19.3mmHg
Term
Osmotic Pressure= _____mmHg(body fluid)*____mmHg
Definition
300mmHg*19.3mmHg
Term

Osmolarity formula

Example:

0.9% NaCl Soln...

Na:22.99

Cl:35.45

Definition

Osm/L: (g/L soulte*Osm/mole)/(GMW)

Ex:

[(9g/L)*(2 osm/mol)]/[22.99+35.45]=.308osm/L

Term
Tonicity
Definition
the ability of a solution to change the tone or shape of cells by alterin ther internal water volume; isotonic, hypertonic, hypotonic
Term
Isotonic
Definition
 denoting a solution in which body cells can be bathed without net flow of water across the semipermeable cell membrane;  Having the same concentration of solutes as the blood
Term
hypertonic
Definition
denoting a solution having greater osmotic pressure than the solution with which it is compared.
Term
Some functions of Membrane Proteins
Definition
Transport protein, intracellular junctions, enzyme, cell-cell recognition, proteins as receptors sites, attachement to the cytoskeleton and extracellular matrix(ECM)
Term
Transport proteins
Definition
a protein that spans the membrane may provide a hydrophilic channel across the membrane that is selective for a particular solute; Hydrolyze ATP as an energy source to actively pump substances across the membrane
Term
Membrane Proteins: Enzyme Function
Definition
active site exposed to substances in the adjacent solution; catalyze sequential steps of a metabolic pathways
Term
Membrane Proteins: Receptor Site
Definition
exposed to the outside to the cell may have a binding site that fits the shape of a chemical messenger(ex. hormones); external signal may cause a conformational change in the protein that initiates a chain of chemical reactions
Term
Membrane Proteins: intracellular junctions
Definition
membrane proteins of adjacent cells may be hooked together at various points; some provide temporary binding sites that guide cell migration and other cell-to-cell interactions
Term
Membrane Proteins: cell-cell recognition
Definition
some gylcoproteins(proteins bonded to short chains of sugar) serve a identification tags that are specifically recognized by other cells
Term
Attachment to the cytoskeleton and extracellular matrix (ECM)
Definition
actin filaments or other elements internal supports may be attached to membrane proteins; helps maintain cell shape and fixes the location of certain membrane proteins
Term

Stages of mitosis: Interphase

 

Definition

DNA has replicated, but has not formed the condensed structure of chromosome. They remain as loosely coiled chromatin.

The nuclear membrane is still intact to protect the DNA molecules from undergoing mutation.

Term
Stages of mitosis: Prophase
Definition

The DNA molecules progressively shortenand condense by coiling, to form chromosomes. The nuclear membrane and nucleolus are no longer visible; 

The spindle apparatus has migrate to opposite poles of the cell.

Term

Stages of mitosis: Metaphase

 

Definition
The spindle fibers attached themselves to the centromeres of the chromosomes and align the chromosomes at the equatorial plate.
Term

Stages of mitosis: Anaphase


Definition
The spindle fibers ahorten and the centromere splits, seperated sister chromatids are pulled along behind the centromeres.
Term

Stages of mitosis: Telophase & Cytokinesis

 

Definition
the chromosomes reach the poles of their respective spindles. Nuclear reform before the chromosomes uncoil. Nuclear envelop forming and cleave forming; spindle fibers disintegrate.
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