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human dev. 2d
d
38
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Undergraduate 4
02/16/2012

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Term
cytotrophoblast
Definition
-trophoblast implantation
-inner layer of cells
-remains around blastocyst
Term
syncytiotrophoblast
Definition
-trophoblast implantation
-outer layer of cells
-cells lose pl. mem. and contents invade and digest endometrium
-blastocyst burrows into endometrial lining
-makes room for blastocyst
Term
human chorionic gonadotropin (hCG)
Definition
-secreted by trophblast cells, later the chorion
-promts corpus luteum to continue secretion of progest. and estrogen
-hCG levels rise until end of 2nd month, then decline as placenta secretes proges. and estr.
Term
embryonic tissues
Definition
-cells develop from the ICM and line the trophoblast
-these form the chorion and chroionic villi
Term
chorionic villi
Definition
-grow into blood-filled lacunae
-vascularized by umbilical arteries/veins
-lie immersed in maternal blood
Term
decidua basalis (maternal tissue)
Definition
part of the endometrium outside of chorionic villi
Term
decidua capsularis (maternal tissue)
Definition
-part of the endometrium at the uterine cavity face of the implanted embryo
-lumen of uterus
Term
placenta
Definition
-combo of chorionic villi and decidua basalis
-fully formed and func. by end of 3rd mt
-hormone production
-oxy, nutrient, waste exchange
Term
amnion
Definition
-epiblast cells from a transparent sac filled with amniotic fluid
-protects embryo
-maintains temp
-freedom of movement and prevents parts from fusing together
-am. fluid comes from maternal blood, and later from fetal urine
Term
yolk sac
Definition
-hangs from ventral surface of embryo
-from hypoblast
-later forms part of digestive tract
-source of earliest blood cells and veseels
Term
allantois
Definition
-small outpocketing at caudal end of yolk sac
-structural base for umbilical cord (connective tissue)
-becomes part of urinary bladder
Term
chorion
Definition
-helps form placenta
-encloses the embryonic body and all other membranes
Term
the 4 extraembryonic membranes are...
Definition
amnion, yolk sac, allantois, and chorion
Term
gastrulation occurs in..
Definition
week 3. embryonic disc becomes a 3 layered embryo with mesoderm, ectoderm, and endoderm
Term
notochord
Definition
-rod of mesodermal cells that serves as axial support.
-directly beneath primitive streak
Term
ectoderm forms
Definition
nervous system and skin epidermis
Term
endoderm forms
Definition
epithelial linings of digestive, respiratory, and urogenital systems
Term
organogenesis
Definition
-after gastrulation
-formation of body organs and systems
-day 16
-8th wk all organ systems are recognizable and end of embryonic period
Term
neurulation
Definition
-occurs in ectoderm
-1st event of organogenesis
-gives rise to brain and spinal chord
-happens right over notochord
Term
meroencephaly
Definition
partial absence of brain
Term
spina bifida
Definition
incomplete closure of neural tube
Term
3 mesoderm aggregates
Definition
-somites, intermediate mesoderm, and lateral plate mesoderm.
-appear lateral to notochord
-occur in segmented pairs along length of embryo
Term
somites
Definition
-40 pairs
-each have three functional parts
Term
sclerotome cells
Definition
produce verebra and rib at each level
Term
dermatome cells
Definition
form dermis of skin on dorsal part of body
Term
myotome cells
Definition
form skeletal muscles of neck, trunk, and limbs
Term
intermediate mesoderm form...
Definition
forms gonads and kidneys
Term
lateral mesoderm forms...
Definition
-dermis of skin in ventral region
-bones, ligaments, and dermis of limbs
-heart and blood vessels
-most connective tissues of body
-smooth muscle, connective tissue, and serosa of digestive and resp. organs
Term
fetal alcohol syndrome (FAS)
Definition
microcephaly, mental retardation, abnormal growth
Term
morphogens
Definition
diffusible molecules that specify differentiation of a cell type at a specific location and/or direct migration of cells
Term
retinoid acid
Definition
-active form of vit. A
-"posteriorizes" the body: high conc. in embryo induce posterior structures to form
Term
TGFB/BMP
Definition
-family of proteins
-help establish dorsal/ventral patterns
Term
Wnt proteins
Definition
-secreted glycoproteins
-determine cell polarity, proliferation, apoptosis, cell fate, and migration.
Term
hedgehog proteins
Definition
-important for early development
-early patterning, cell migration, differentiation
-ex. shh secreted by notochord: high conc. at floor of neural tube and low conc. at roof.
-high conc induces formation of interneurons and motor neurons: ventral neural patterning
Term
shh mutations
Definition
-many dif altered phenotypes arise
-holoprosencephaly, digit malfunctions
-cyclopamine: investigative cancer treatments but a teratogen
Term
notch/delta signaling
Definition
specifies fate of precursor cells, maintenance of stem cell populations
Term
transcription factors
Definition
-activate or repress downstream genes to direct development
-usually end point of other signaling pathways
-eg. homeobox (hox), paired box (pax)
Term
receptor tyrosine kinases
Definition
-growth factor signaling
-regulate cell proliferation, apop, migration
-growth of new blood vessels and axonal processes
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