Term
| ? is a disease characterized by the buildup of misfolded proteins called prion proteins in the brain |
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Definition
| CJD ( Creutzfeld-Jacob Disease) |
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Term
| Quaternary structure is stabilized by ?-? forces only. |
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Definition
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Term
| Hemoglobin, Aspartate Transcarbamylase, lactate dehydrogenase, Phosphorylase b kinase, and Immunoglobulin G are examples of some ? ? |
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Definition
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Term
| Developmental and tissue specificity is common in ? |
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Definition
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Term
| Lactate Dehydrogenase (LDH) can exist as a ? or a heterotetramer of different combinations of two types of subunits, M and H |
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Definition
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Term
| What is a tetramer of four identical subunits, with four catalytic sites as well as regulatory sites, and it is allosterically INHIBITED by ATP, citrate; ACTIVATED by AMP, Fructose-2,6-BP |
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Definition
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Term
| What enzyme is the key control point for glycolysis |
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Definition
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Term
| What catalyzes first committed step in pyrimidine nucleotide biosynthesis, formation of N-carbamoylaspartate and Pi from carbamoyl phosphate and aspartate |
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Definition
| Aspartate Transcarbamoylase (ATCase) |
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Term
| What enzyme has 2 catalytic trimer (C3) and 3 regulatory dimers (r2) come together to form C6r6 complex and is inhibited (feedback) by CTP; activated by ATP and is also an example of ALLOSTERIC enzyme |
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Definition
| Aspartate Transcarbamoylase (ATCase) |
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Term
| One advantage of not being single for a protein is regulation through ? ? (Hb, PFK-1, ATCase) |
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Definition
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Term
| One advantage of not being single for a protein is channeling of substrates between different ? ? - multienzyme complexes |
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Definition
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Term
| Do proteins spontaneously adopt a folded conformation after they are synthesized by the ribosome of the cell? |
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Definition
| Often times yes sometimes they need added help |
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Term
| What bind to unfolded and partially folded proteins and prevent improper association? Ex HSP-70 and chaperonins |
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Definition
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Term
| Folded states are in equilibrium with unfolded states, though equilibrium is skewed toward the ? ?. |
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Definition
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Term
| Chemical denaturants include ?, Guanidine HCl, and Sodium dodecyl sulfate. Other denaturing agents are heat, low temp, and pH extremes |
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Definition
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Term
| S-S bonds can be broken with beta-mercaptoethanol or ? |
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Definition
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Term
| The irreversible in vivo accumulation of unfolded or misfolded proteins is the under-lying cause of a class of degenerative diseases called ? |
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Definition
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Term
| Examples of amyloidoses are ? ?, mad cow disease (Bovine Spongiform Encephalopathy), Creutzfeld-Jacob disease, other neurodegenerative disorders |
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Definition
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Term
| The belief on prions was heretical because it goes against accepted dogma which says that ? ? must be involved and these proteinaceous infectious particles lack that. |
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Definition
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Term
| Gerstmann-Straussler-Scheinker disease, familial CJD, Fatal familial insomnia are all ? ? in Prp gene |
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Definition
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Term
| What is the mechanism for kuru? |
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Definition
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Term
| The mechanism for variant CJD is? |
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Definition
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Term
| The mechanism for sporadic CJD is ? |
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Definition
| Somatic mutation or spontaneous conversion of PrPc to PrPsc |
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Term
| Latrogenic (hospital caused) CJD is due to ?-? HGH, grafts, etc |
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Definition
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Term
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Definition
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Term
| PrPc to PrPsc involves conversion of two ? ? to ?? |
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Definition
| alpha helices to beta strands |
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Term
| Accumulation of ? always associated with pathology of prion diseases |
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Definition
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Term
| Knock out of PrP gene eliminates substrate for PrPsc formation, and prevents prion disease - no ? |
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Definition
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Term
| PrP gene mutations genetically linked to ? prion disease |
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Definition
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Term
| Glycosidic addition catalyzed by specific ? |
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Definition
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Term
3 roles of glycosylation in glycoproteins include:
1. proper folding of transmembrane proteins.
2.structural stability
3.? |
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Definition
| Recognition for cell adhesion |
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Term
| Blood group A has extra ? |
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Definition
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Term
| Blood group B has extra ? |
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Definition
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Term
| Protein ? promotes resistance to degradation in cell and helps control gene expression in eukaryotes |
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Definition
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Term
| Three common types of attachment for lipidation are: acylation, prenylation, and ? |
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Definition
| glycosylphosphatidylinositl |
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Term
| What two things modulate phosphorylation? |
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Definition
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Term
| ? is common in collagen and elastin; catalyzed by hydroxylases |
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Definition
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Term
| Carboxylation of glutamic acid is often seen in ? ? ? |
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Definition
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Term
| Carboxylation requires ? ? as enzyme cofactor |
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Definition
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Term
| N-linked or O-linked methylation of AA with distal amino acids exhibited by ? and ? |
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Definition
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Term
| N-linked or O-linked methylation of carboxyl groups exhibited by ? and ? |
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Definition
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Term
| ? use energy released from ATP hydrolysis to move specific ions against an electro chemical gradient. Also an example? |
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Definition
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Term
| ? permit the movement of ions down their electrochemical gradient (passive transport) Ex? |
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Definition
Channels
Nongated ion channels (Na+, Ca++, Cl-) |
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Term
| ? facilitate movement of specific small molecules or ions. Ex? |
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Definition
Transporters
GLUT 1 - 12 (ex. of uniporter which transport a single molecule down its conc gradient) |
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