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HUCM Enzymes 2
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17
Medical
Graduate
08/06/2011

Additional Medical Flashcards

 


 

Cards

Term
K3 = kcat = ? ?
Definition
turnover number
Term

?-? occurs for Michaelis-Mentin kinetics when d[ES]/dt=0

i.e., the rate of formation of [??] = its rate of disappearance

Definition

Steady-State

[ES]

Term
Rate during steady state (SS) is defined as the ? ? (?)
Definition
Initial Velocity (vi)
Term
? = VmaxS/Km + S
Definition
vi
Term

?= k3[E]T

The units for this are ?/?

Definition

Vmax

M/t

Term

? = k2 + k3/k1

Units are ?   (t-1/M-1t-1)

Definition

Km

M

Term

Most biochemical reactions require ? ? ? substrate.

 

Definition
more than one
Term
The order of binding of substrates, however, will dictate the type of ? ? observed.
Definition
kinetic pattern
Term

Example of reversible inhibitor:

? for SDH

Definition
Malonate
Term
Example of irreversible inhibitor:
? for GA3PD 
Definition
Iodoacetate
Term

Special cases of inhibitor types

a. Active Site Directed

b. ? ? ?

c. ? ? (?)

Definition

b. Transition state analogs

c. Mechanism based (suicide)

Term

? = ( [I]/(Kmi/Km)-1  )

where Kmi is apparent Km in the presence of inhibitor

Definition

Ki

 

Term
What is the inhibitor of succinate dehydrogenase
Definition
Succinate
Term
What is the inhibitor of succinate dehydrogenase?
Definition
Malonate
Term
what is the reciprocal of the y-intercept?
Definition
Vmax
Term
what is the quotient of the slope/intercept ratio?
Definition
Km
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