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HUCM Cell Adhesion
Descriptive
61
Medical
Professional
09/13/2011

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Cards

Term
What are described as complexes forming at specific sites of cell membranes
Definition
Cell Adhesions
Term
3 typical components of INTERcellular junctions are what?
Definition
transmembrane ahesive protein
cytoplasmic adapter protein
cytoskeletal filament
Term
What INTERcellular junction arrangement is described as a patch-like junction of limited extent?
Definition
Macula
Term
What INTERcellular junction arrangement is described as a junction which encircles the entire cell?
Definition
Zonula
Term
In INTERcellular junctions where is the junctional complex (terminal bar) located?
Definition
cuboidal or columnar epithelium
Term
In INTERceullular junctions junctional combinations where is the intercalated disc located?
Definition
cardiac muscle
Term
What is a type of communicating junction?
Definition
Gap Junction
Term
What are some examples of a tight junction
Definition
occluding junction, zonula occludens
Term
What are some examples of an adhering junction (which is an adhesive junction)
Definition
adherens junction
zonula adherens
Term
In the realm of adhesive junctions, a macula adherens is considered a ?
Definition
DESMOSOME
Term
What are two examples of cells attaching to/anchoring in the extracellular matrix?
Definition
Hemidesmosome
Focal Adhesion
Term
What type of junction is a plaque like junction and has cell membranes of neighboring cells very close together; intercellular space only 2-3 nm
Definition
Gap-communicating junction
Term
Gap/communicating junction can be found in...
Definition
all basic tissue types
Term
What junction is common in epithelial cells, smooth and cardiac muscle cells, neuronal cells, and osteocytes?
Definition
Gap-communicating junction
Term
What is the integral membrane protein in gap/communication junctions?
Definition
connexin
Term
How many connexins form a connexon?
Definition
6
Term
Connexons of one cell connect to connexons in adjacent cell to form ?
Definition
hydrophilic channel
Term
What can be passed through gap junctions?
Definition
Small signaling molecules and ions
Term
In gap junctions connected cells are ? coupled for coordinated responses to stimuli?
Definition
electrically
Term
tight/occluding junctions have ? strands of adhesive transmembrane proteins.
They also have ? series of contacts to proteins of adjacent cell.
Definition
anastomosing
linear
Term
In what junction is the intercellular space obliterated at contact site?
This type of junction encircles what?
Definition
Tight/occluding junction
entire cell
Term
Tight/occluding junctions are found where?
Definition
close to apical end of cuboidal or columnar epithelial cells
Term
Tight/occluding junction has Transmembrane proteins: members of ?family (4 pass membrane proteins); also: occludin, junctional adhesive molecule
Definition
claudin
Term
In tight/occluding junction Some cytoplasmic proteins: ?, transcription factors, cell polarity-related proteins
Definition
kinases
Term
In tight/occluding junction what filaments are associated?
Definition
Actin
Term
In tight/occluding junction Movement of ions and small molecules in intercellular space is?
Definition
prevented/controlled
Term
Tightness of occluding junction depends on?
Definition
number of junctional strands, their completeness, and type of adhesive protein
Term
In tight/occluding junction movment of mem. proteins is
Definition
limited
Term
Tight/occluding junction has ...
Definition
cell adhesion
Term
What junction? Cells held together or attached to / anchored in the extracellular matrix
Definition
Adhesive junctions
Term
What junction? Intercellular space between attached cells: 20 nm wide at location of adhesive junction
Definition
Adhesive junction
Term
Adhesive junctions commonly involved in (intra) ?
Definition
) cellular signaling (e.g. for nuclear transcription, tumor suppression, differentiation)
Term
In adhesive junctions Loss of contact to adjacent cells or extracellular matrix may trigger
Definition
apoptosis or result in loss of polarity
Term
In adhesive junctions:

Cell-to-cell adhesive junctions:
Transmembrane adhesive proteins members of ? (calcium ion-dependent proteins) family
Cytoplasmic adapter proteins members of the ? family
Definition
cadherin
catenin
Term
In adhesive junctions:
Cell-to-ECM adhesive junctions:
Similar to cell-to-cell adhesive junctions, but:
Transmembrane proteins members of ? family (heterodimers with alpha and beta subunits
Definition
integrin
Term
What is an Adhesive junction with electron-lucent intercellular space and ‘fuzzy’ plaque on cytoplasmic face

Associated with belt-like band of actin

Encircles entire cell (zonula)

Found basal to tight junction zonula in epithelial cells
Definition
Adhering junction
Term
What junction

Transmembrane adhesive proteins: E-cadherin; (nectin)

Cytoplasmic adapter proteins: - and -catenin; (p120 catenin, afadin, vinculin, -actinin)

Catenins interact with cytoplasmic domain of trans-membrane protein, cytoskeletal proteins, and other cytoplasmic proteins

Cytoskeletal element: actin filaments (continuous with apical terminal web)
Definition
Adhering junction
Term
What junction?
Contribution to adhesive force between one cell and another

Support to apical domain of epithelial cell

Intracellular signaling
Definition
Adhering junction
Term
What junction?
Disk-shaped adhesive junction (macula)

Electron-dense cytoplasmic attachment plaque
Definition
Desmosome
Term
What junction?

Intercellular space (ca. 30 nm; somewhat wider than in ZA) filled with highly-ordered proteins

Found basal to zonula adherens in epithelial cells in band encircling cell as well as scattered over lateral cell surface

Common in many tissue types
Definition
Desmosome
Term
What has Transmembrane adhesive proteins (cadherins): desmoglein, desmocollin
Definition
desmosome
Term
Interaction of cadherins from adjacent cells results in?
Definition
electron-dense line in intercellular space
Term
What has Cytoplasmic adapter proteins (catenins): desmoplakin, plakoglobin, plakophilin

Cytoskeletal element: intermediate filaments (anchoring in catenin plaque); type depends on tissue type
Definition
desmosome
Term
What?
Attachment site for strong cytoskeletal components (intermediate filaments)

Provides firm adhesion among cells
Definition
desmosome
Term
What does this?

Sheet-like arrangement of extracellular matrix proteins ( ca. 20-100 nm wide)

Binds epithelium to underlying connective tissue

Also found around muscle cells and nerve fibers
Definition
Basal lamina/basement membrane
Term
What does this?

Provides metabolic support

Filters material (barrier function)

Controls epithelial growth and differentiation; prevents downward epithelial growth
Definition
Basal lamina/ basement membrane
Term
The components of the basal lamina/basement membrane are:
Heparan sulfate (glycosamino-glycan)
Collagen type IV
Fibronectin
Laminin
and what 3 things?
Definition
Entactin
Collagen type 3
Collagen type 7 (anchoring fibrils)
Term
what are the layers of the basal lamina/basement membrane (visible only in TEM)???
Definition
Lamina lucida
Lamina densa
Lamina fibroreticularis
Term
What is this?
Plaque-like adhesive junction morphologically similar to a half-desmosome

Forms at the basal side of certain epithelial cells in zone of contact with basal lamina
Definition
Hemidesmosome
Term
What are the TME and CSE for Focal Adhesion?
Definition
TME: integrin
CSE: actin
Term
What are the TME and CSE for Focal Adhesion?
Definition
TME: integrin
CSE: actin
Term
What are the TME and CSE for Hemidesmosome?
Definition
TME: integrin
CSE: intermediate filament
Term
What is this?
Transmembrane adhesive proteins: integrin (64)

Integrins bind to basal lamina glycoprotein laminin

Cytoplasmic adapter proteins: bulbous pemphigoid antigen 230 (BP230); plectin
Definition
Hemidesmosome
Term
What is this?

Cytoplasmic proteins form dense plaque

Cytoskeletal element: intermediate filaments (anchoring in plaque)
Definition
Hemidesmosome
Term
What is this?

Provides tight anchoring of epithelial cell to basal lamina and underlying connective tissue
Definition
Hemidesmosome
Term
What is this?

Dynamic assembly of many (>50) different proteins

Provides linkage of cell to extracellular matrix

Important for intracellular signaling
Definition
Focal Adhesion
Term
What is this?
Transmembrane adhesive protein: integrin heterodimers

Cytoplasmic adapter proteins: -actinin, vinculin, talin

Cytoskeletal element: actin filaments

Integrins bind to ECM proteins fibronectin, laminin, collagen
Definition
Focal Adhesion
Term
Genetic abnormalities or autoimmune responses of / to transmembrane and cytoplasmic junctional proteins can affect what 3 things?
Definition
function
differentiation
development of cells
Term
What is linked to:
: deafness, cataracts, Charcot-Marie-Tooth demyelinating disease, oculodentaldigital dysplasia
Definition
Connexin mutations
Term
What is : linked to mutations of genes for desmosomal, hemidesmosomal, and intermediate filament proteins
Definition
Epidermolysis bullosa
Term
What is linked to the auotimmune disease affecting oral mucosa due to production of antibodies to cadherins in desmosomes?
Definition
Pemphigus Vulgaris
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