Chlrothalidone

1.  Brand

2.  ADE

3.  Drug class

1.  Thalitone

2.  Hyperuricemia, hyopkalemia, hypomagnesemia, hyperglycemia, hyponatremia, hypercalcemia, hypercholesterolemia, hypertriglyceridemia, pancreatitis, rash and other allergic reactions, sexual dysfunction in men, photosensitivity

3.  Thiazide-type diuretic

Chlorothiazide

1.  Brand

2.  ADE

3.  Drug class

1.  Diuril

2.  Hyperuricemia, hyopkalemia, hypomagnesemia, hyperglycemia, hyponatremia, hypercalcemia, hypercholesterolemia, hypertriglyceridemia, pancreatitis, rash and other allergic reactions, sexual dysfunction in men, photosensitivity

3.  Thiazide-type diuretic

HCTZ

1.  Brand

2.  ADE

3.  Drug class

1.  Microzide

2.  Hyperuricemia, hyopkalemia, hypomagnesemia, hyperglycemia, hyponatremia, hypercalcemia, hypercholesterolemia, hypertriglyceridemia, pancreatitis, rash and other allergic reactions, sexual dysfunction in men, photosensitivity

3.  Thiazide-type diuretic

Indapamide

1.  Brand

2.  ADE

3.  Special feature

4.  Drug class

1.  No brand listed

2.  Hyperuricemia, hyopkalemia, hypomagnesemia, hyperglycemia, hyponatremia, hypercalcemia, hypercholesterolemia, hypertriglyceridemia, pancreatitis, rash and other allergic reactions, sexual dysfunction in men, photosensitivity

3.  Can be given with CrCl<30 mL/min

4.  Thiazide-type diuretic

Metolazone

1.  Brand

2.  ADE

3.  Drug class

1.  Zaroxolyn

2.  Hyperuricemia, hyopkalemia, hypomagnesemia, hyperglycemia, hyponatremia, hypercalcemia, hypercholesterolemia, hypertriglyceridemia, pancreatitis, rash and other allergic reactions, sexual dysfunction in men, photosensitivity

3.  Thiazide-like diuretic

Bumetanide

1.  Brand

2.  ADE

3.  Drug class

1.  None given

2.  Dehydration, circulatory collapse, hypokalemia, hyponatremia, hypomagnesemia, hyperglycemia, metabolic alkalosis, hyperuricemia, blood dyscrasias, rash, hypercholesterolemia, hypertriglyceridemia

3.  Loop diuretic

Ethacrynic acid

1.  Brand

2.  ADE

3.  Drug class

1.  Edecrin

2.  Dehydration, circulatory collapse, hypokalemia, hyponatremia, hypomagnesemia, hyperglycemia, metabolic alkalosis, hyperuricemia, blood dyscrasias, rash, hypercholesterolemia, hypertriglyceridemia

3.  Loop diuretic

Furosemide

1.  Brand

2.  ADE

3.  Drug class

1.  Lasix

2.  Dehydration, circulatory collapse, hypokalemia, hyponatremia, hypomagnesemia, hyperglycemia, metabolic alkalosis, hyperuricemia, blood dyscrasias, rash, hypercholesterolemia, hypertriglyceridemia

3.  Loop diuretic

Torsemide

1.  Brand

2.  ADE

3.  Drug class

1.  Demadex

2.  Dehydration, circulatory collapse, hypokalemia, hyponatremia, hypomagnesemia, hyperglycemia, metabolic alkalosis, hyperuricemia, blood dyscrasias, rash, hypercholesterolemia, hypertriglyceridemia

3.  Loop diuretic

Amiloride

1.  Brand

2.  ADE

3.  Category

1.  Midamor

2.  Hyperkalemia, GI disturbances, rash, headache

3.  Potassium sparing diuretic

Eplerenone

1.  Brand

2.  ADE

3.  Drug class

1.  Inspra

2.  Hyperkalemia, hyponatremia

3.  Potassium-sparing diuretic

Spironolactone

1.  Brand

2.  ADE

3.  Drug class

1.  Aldactone

2.  Hyperkalemia, hyponatremia, mastodynia, gynecomastia, menstrual abnormalities, GI disturbances, rash

3.  Potassium-sparing diuretic

Triamterene

1.  Brand

2.  ADE

3.  Drug class

1.  Dyrenium

2.  Hyperkalemia, GI disturbances, nephrolithiasis

3.  Potassium-sparing diuretics

Benazepril

1.  Brand

2.  ADE

3.  Drug class

1.  Lotensin

2.  Cough, hypotension (esp with diuretic), rash, acute renal failure, angioedema, hyperkalemia, mild-to-moderate loss of taste, hepatotoxicity, pancreatitis, blood dyscrasias and renal damage, increased fetal malformations and mortality with use in pregnancy

3.  ACEI

Captopril

1.  Brand

2.  ADE

3.  Drug Class

1.  Capoten

2.  Cough, hypotension (esp with diuretic), rash, acute renal failure, angioedema, hyperkalemia, mild-to-moderate loss of taste, hepatotoxicity, pancreatitis, blood dyscrasias and renal damage, increased fetal malformations and mortality with use in pregnancy

3.  ACEI

Enalapril

1.  Brand

2.  ADE

3.  Drug class

1.  Vasotec

2.  Cough, hypotension (esp with diuretic), rash, acute renal failure, angioedema, hyperkalemia, mild-to-moderate loss of taste, hepatotoxicity, pancreatitis, blood dyscrasias and renal damage, increased fetal malformations and mortality with use in pregnancy

3.  ACEI

Fosinopril

1.  Brand

2.  ADE

3.  Drug class

1.  Monopril

2.  Cough, hypotension (esp with diuretic), rash, acute renal failure, angioedema, hyperkalemia, mild-to-moderate loss of taste, hepatotoxicity, pancreatitis, blood dyscrasias and renal damage, increased fetal malformations and mortality with use in pregnancy

3.  ACEI

Lisinopril

1.  Brand

2.  ADE

3.  Drug class

1.  Prinivil, Zestril

2.  Cough, hypotension (esp with diuretic), rash, acute renal failure, angioedema, hyperkalemia, mild-to-moderate loss of taste, hepatotoxicity, pancreatitis, blood dyscrasias and renal damage, increased fetal malformations and mortality with use in pregnancy

3.  ACEI

Moexipril

1.  Brand

2.  ADE

3.  Drug class

1.  Univasc

2.  Cough, hypotension (esp with diuretic), rash, acute renal failure, angioedema, hyperkalemia, mild-to-moderate loss of taste, hepatotoxicity, pancreatitis, blood dyscrasias and renal damage, increased fetal malformations and mortality with use in pregnancy

3.  ACEI

Perindopril

1.  Brand

2.  ADE

3.  Drug class

1.  Aceon

2.  Cough, hypotension (esp with diuretic), rash, acute renal failure, angioedema, hyperkalemia, mild-to-moderate loss of taste, hepatotoxicity, pancreatitis, blood dyscrasias and renal damage, increased fetal malformations and mortality with use in pregnancy

3.  ACEI

Quinapril

1.  Brand

2.  ADE

3.  Drug class

1.  Accupril

2.  Cough, hypotension (esp with diuretic), rash, acute renal failure, angioedema, hyperkalemia, mild-to-moderate loss of taste, hepatotoxicity, pancreatitis, blood dyscrasias and renal damage, increased fetal malformations and mortality with use in pregnancy

3.  ACEI

Ramipril

1.  Brand

2.  ADE

3.  Drug class

1.  Altace

2.  Cough, hypotension (esp with diuretic), rash, acute renal failure, angioedema, hyperkalemia, mild-to-moderate loss of taste, hepatotoxicity, pancreatitis, blood dyscrasias and renal damage, increased fetal malformations and mortality with use in pregnancy

3.  ACEI

Trandolapril

1.  Brand

2.  ADE

3.  Drug class

1.  Mavik

2.  Cough, hypotension (esp with diuretic), rash, acute renal failure, angioedema, hyperkalemia, mild-to-moderate loss of taste, hepatotoxicity, pancreatitis, blood dyscrasias and renal damage, increased fetal malformations and mortality with use in pregnancy

3.  ACEI

Azilsartan

1.  Brand

2.  ADE

3.  Drug class

1.  Edarbi

2.  Similar to ACEI, including increased fetal mortality with pregnancy, but do not cause cough and only rarely cause angioedema, loss of taste and hepatotoxicity; rarely rhabdomyolysis

2.  ARB

Candesartan

1.  Brand

2.  ADE

3.  Drug class

1.  Atacand

2.  Similar to ACEI, including increased fetal mortality with pregnancy, but do not cause cough and only rarely cause angioedema, loss of taste and hepatotoxicity; rarely rhabdomyolysis

3.  ARB

Eprosartan

1.  Brand

2.  ADE

3.  Drug class

1.  Teveten

2.  Similar to ACEI, including increased fetal mortality with pregnancy, but do not cause cough and only rarely cause angioedema, loss of taste and hepatotoxicity; rarely rhabdomyolysis

3.  ARB

Irbesartan

1.  Brand

2.  ADE

3.  Drug class

1.  Avapro

2.  Similar to ACEI, including increased fetal mortality with pregnancy, but do not cause cough and only rarely cause angioedema, loss of taste and hepatotoxicity; rarely rhabdomyolysis

3.  ARB

Losartan

1.  Brand

2.  ADE

3.  Drug class

1.  Cozaar

2.  Similar to ACEI, including increased fetal mortality with pregnancy, but do not cause cough and only rarely cause angioedema, loss of taste and hepatotoxicity; rarely rhabdomyolysis

3.  ARB

Olmesartan

1.  Brand

2.  ADE

3.  Drug class

1.  Benicar

2.  Similar to ACEI, including increased fetal mortality with pregnancy, but do not cause cough and only rarely cause angioedema, loss of taste and hepatotoxicity; rarely rhabdomyolysis

3.  ARB

Telmisartan

1.  Brand

2.  ADE

3.  Drug class

1.  Micardis

2.  Similar to ACEI, including increased fetal mortality with pregnancy, but do not cause cough and only rarely cause angioedema, loss of taste and hepatotoxicity; rarely rhabdomyolysis

3.  ARB

Valsartan

1.  Brand

2.  ADE

3.  Drug class

1.  Diovan

2.  Similar to ACEI, including increased fetal mortality with pregnancy, but do not cause cough and only rarely cause angioedema, loss of taste and hepatotoxicity; rarely rhabdomyolysis

3.  ARB

Aliskiren

1.  Brand

2.  ADE

3.  Drug class

1.  Tekturna

2.  Same as ARBs, but can also cause GI effects such as diarrhea

3.  Direct renin inhibitor

Amlodipine

1.  Brand

2.  ADE

3.  Drug class

1.  Norvasc

2.  Dizziness, headache, peripheral edema (more common in women), flushing, tachycardia, rash, gingival hyperplasia

3.  Dihydropyridine CCB

Felodipine

1.  Brand

2.  ADE

3.  Drug class

1.  Plendil

2.  Dizziness, headache, peripheral edema (more common in women), flushing, tachycardia, rash, gingival hyperplasia

3.  Dihydropyridine CCB

Isradipine

1.  Brand

2.  ADE

3.  Drug class

1.  DynaCirc CR (Extended-release)

2.  Dizziness, headache, peripheral edema (more common in women), flushing, tachycardia, rash, gingival hyperplasia

3.  Dihydropyridine CCB

Nifedipine

1.  Brand

2.  ADE

3.  Drug class

1.  Adalat CC; Procardia XL (Extended-release)

2.  Dizziness, headache, peripheral edema (more common in women), flushing, tachycardia, rash, gingival hyperplasia

3.  Dihydropyridine CCB

Nisoldipine

1.  Brand

2.  ADE

3.  Drug class

1.  Sular

2.  Dizziness, headache, peripheral edema (more common in women), flushing, tachycardia, rash, gingival hyperplasia

3.  Dihydropyridine CCB

Diltiazem

1.  Brand

2.  ADE

3.  Drug class

1.  Extended-Release:  Cardizem LA

Sustained-Release:  Taztia XT, Tiazac

Continuous delivery:  CArdizem CD, CArtia XT, Dilt-CD

2.  Dizziness, headache, edema, constipation (verapamil), AV block, bradycardia, HF, lupus-like rash with diltiazem

3.  Non-Dihydropyridine CCB

Verapamil

1.  Brand

2.  ADE

3.  Drug class

1.  Extended release:  Calan SR, Isoptin SR, Covera-HS, Verelan, Verelan PM

2.  Dizziness, headache, edema, constipation (verapamil), AV block, bradycardia, HF, lupus-like rash with diltiazem

3.  Non-Dihydropyridine CCB

Nicardipine

1.  Brand

2.  ADE

3.  Drug class

1.  Cardene SR

2.  Dizziness, headache, peripheral edema (more common in women), flushing, tachycardia, rash, gingival hyperplasia

3.  Dihydropyridine CCB

Atenolol

1.  Brand

2.  ADE

3.  Drug Class

1.  Tenormin

2.  Fatigue, depression, bradycardia, ED, decreased exercise tolerance, HF, worsening of peripheral arterial insufficiency, bronchospasm, mask symptoms of hypoglycemia, Raynaud’s phenomenon, insomnia, vivid dreams or hallucinations, acute mental disorder, increased serum triglycerides, decreased HDL cholesterol, increased incidence of diabetes, sudden withdrawal may lead to exacerbation of angina and MI

3.  Beta-blocker

Betaxolol

1.  Brand

2.  ADE

3.  Drug class

1.  None given

2.  Fatigue, depression, bradycardia, ED, decreased exercise tolerance, HF, worsening of peripheral arterial insufficiency, bronchospasm, mask symptoms of hypoglycemia, Raynaud’s phenomenon, insomnia, vivid dreams or hallucinations, acute mental disorder, increased serum triglycerides, decreased HDL cholesterol, increased incidence of diabetes, sudden withdrawal may lead to exacerbation of angina and MI

3.  Beta-blocker

Bisoprolol

1.  Brand

2.  ADE

3.  Drug class

1.  Zebeta

2.  Fatigue, depression, bradycardia, ED, decreased exercise tolerance, HF, worsening of peripheral arterial insufficiency, bronchospasm, mask symptoms of hypoglycemia, Raynaud’s phenomenon, insomnia, vivid dreams or hallucinations, acute mental disorder, increased serum triglycerides, decreased HDL cholesterol, increased incidence of diabetes, sudden withdrawal may lead to exacerbation of angina and MI

3.  Beta-blocker

Metoprolol

1.  Brand

2.  ADE

3.  Drug class

1.  Lopressor; Extended-release:  Toprol-XL

2.  Fatigue, depression, bradycardia, ED, decreased exercise tolerance, HF, worsening of peripheral arterial insufficiency, bronchospasm, mask symptoms of hypoglycemia, Raynaud’s phenomenon, insomnia, vivid dreams or hallucinations, acute mental disorder, increased serum triglycerides, decreased HDL cholesterol, increased incidence of diabetes, sudden withdrawal may lead to exacerbation of angina and MI

3.  Beta-blocker

Nadolol

1.  Brand

2.  ADE

3.  Drug class

1.  Corgard

2.  Fatigue, depression, bradycardia, ED, decreased exercise tolerance, HF, worsening of peripheral arterial insufficiency, bronchospasm, mask symptoms of hypoglycemia, Raynaud’s phenomenon, insomnia, vivid dreams or hallucinations, acute mental disorder, increased serum triglycerides, decreased HDL cholesterol, increased incidence of diabetes, sudden withdrawal may lead to exacerbation of angina and MI

3.  Beta-blocker

Propranolol

1.  Brand

2.  ADE

3.  Drug class

1.  Inderal

Extended-release:  Inderal LA, InnoPran XL

2.  Fatigue, depression, bradycardia, ED, decreased exercise tolerance, HF, worsening of peripheral arterial insufficiency, bronchospasm, mask symptoms of hypoglycemia, Raynaud’s phenomenon, insomnia, vivid dreams or hallucinations, acute mental disorder, increased serum triglycerides, decreased HDL cholesterol, increased incidence of diabetes, sudden withdrawal may lead to exacerbation of angina and MI

3.  Beta-blocker

Timolol

1.  Brand

2.  ADE

3.  Drug class

1.   None given

2.  Fatigue, depression, bradycardia, ED, decreased exercise tolerance, HF, worsening of peripheral arterial insufficiency, bronchospasm, mask symptoms of hypoglycemia, Raynaud’s phenomenon, insomnia, vivid dreams or hallucinations, acute mental disorder, increased serum triglycerides, decreased HDL cholesterol, increased incidence of diabetes, sudden withdrawal may lead to exacerbation of angina and MI

3.  Beta-blocker

Acebutolol

1.  Brand

2.  ADE

3.  Drug class

1.  Sectral

 2.  Similar to other beta-adrenergic blocking drugs, but with less resting bradycardia and lipid changes, acebutolol has been associated with a positive ANA test and occasional drug-induced lupus

3.  Beta-blocker with ISA

Penbutolol

1.  Brand

2.  ADE

3.  Drug class

1.  Levatol

2.  Similar to other beta-adrenergic blocking drugs, but with less resting bradycardia and lipid changes, acebutolol has been associated with a positive ANA test and occasional drug-induced lupus

3.  Beta-blocker with ISA

Pindolol

1.  Brand

2.  ADE

3.  Drug class

1.  None given

2.  Similar to other beta-adrenergic blocking drugs, but with less resting bradycardia and lipid changes, acebutolol has been associated with a positive ANA test and occasional drug-induced lupus

3.  Beta-blocker with ISA

Carvedilol

1.  Brand

2.  ADE

3.  Drug class

1.  Coreg; ER:  Coreg CR

2.  Similar to other beta-blockers, but more orthostatic hypotension; hepatotoxicity

3.  Beta-Blockers with Alpha-Blocking Activity

Labetalol

1.  Brand

2.  ADE

3.  Drug Class

1.  Trandate

2.  Similar to other beta-blockers, but more orthostatic hypotension; hepatotoxicity

3.  Beta-Blockers with Alpha-Blocking Activity

Nebivolol

1.  Brand

2.  ADE

3.  Drug Class

1.  Bystolic

2.  Similar to other B-blockers but may not cause impotence and may improve ED

3.  Beta-blockers with vasodilating NO-mediated activity

Doxazosin

1.  Brand

2.  ADE

3.  Drug class

1.  Cardura

2.  Syncope with first dose (less likely than terazosin and doxazosin), dizziness and vertigo, HA, palpitations, fluid retention, drowsiness, weakness, anticholinergic effects, priapism, thrombocytopenia, arterial fibrillation

2.  Alpha-Adrenergic Blockers

Prazosin

1.  Brand

2.  ADE

3.  Drug class

1.  Minipress

2.  Syncope with first dose (less likely than terazosin and doxazosin), dizziness and vertigo, HA, palpitations, fluid retention, drowsiness, weakness, anticholinergic effects, priapism, thrombocytopenia, arterial fibrillation

2.  Alpha-Adrenergic Blockers

Terazosin

1.  Brand

2.  ADE

3.  Drug class

1.  Hytrin

2.  Syncope with first dose (less likely than terazosin and doxazosin), dizziness and vertigo, HA, palpitations, fluid retention, drowsiness, weakness, anticholinergic effects, priapism, thrombocytopenia, arterial fibrillation

2.  Alpha-Adrenergic Blockers

Clonidine

1.  Brand

2.  ADE

3.  Drug class

1.  Catapres; Transdermal:  Catapres TTS

2.  CNS reactions similar to methyldopa, but more sedation and dry mouth; bradycardia, heart block, rebound HTN (less from patch), contact dermititis from patch

3.  Central Alpha-Adrenergic Agonist

Guanfacine

1.  Brand

2.  ADE

3.  Drug class

1.  Not given

2.  Similar to clonidine, but milder

3.  Central Alpha-Adrenergic Agonist

Methyldopa

1.  Brand

2.  ADE

3.  Drug class

1.  None given

2.  Sedation, fatigue, depression, dry mouth, orthostatic hypotension, bradycardia, heart block, autoimmune disorders (including colitis, hepatitis), hepatic necrosis, Coombs-positive hemolytic anemia, lupus-like syndrome, thrombocytopenia, red cell aplasia, impotence

3.  Central Alpha-Adrenergic Agonist

Hydralazine

1.  Brand

2.  ADE

3.  Drug Class

1.  None given

2.  Tachycardia, aggravation of angina, headache, dizziness, fluid retention, nasal congestion, lupus-like syndrome, hepatitis

3.  Direct Vasodilators

Minoxidil

1.  Brand

2.  ADE

3.  Drug class

1.  None given

2.  Tachycardia, aggravation of angina, marked fluid retention, pericardial effusion, hair growth on face and body

3.  Direct Vasodilators

Reserpine

1.  Brand

2.  ADEs

3.  Drug class

1.  None given

2.  Nasal stuffiness, drowsiness, GI disturbancs, bradycardia, depression, nightmares with high doses, tardive dyskinesia

3.  Peripheral Adrenergic Neuron Antagonists

Benazepril/HCTZ

1.  Brand

Captopril/HCTZ

1.  Brand

Enalapril/HCTZ

1.  Brand

Fosinopril/HCTZ

1.  Brand

Dyazide

Maxzide