Term
| In Hodgkin's Lymphoma, B symptoms are common. What are the 3 classic B symptoms? |
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Definition
| fever, drenching sweats, and weight loss |
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Term
| What subset of Hodgkin's Lymphoma accounts for 5% of cases? |
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Definition
| Nodular Lymphocyte Predominant Hodgkin's Lymphoma |
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Term
| The majority of cells in Hodgkin's Lymphoma are of what type? |
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Definition
| Non-neoplastic multilineage inflammatory cell background |
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Term
| The nodular lymphocyte type of Hodgkin's affects what age group and gender predominantly? |
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Definition
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Term
| True or False- Nodular Lymphocyte Hodgkin's is associated with latent EBV? |
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Definition
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Term
| In nodular lymphocyte Hodgkin's, what is special about the morphology of Reed Sternberg cells? |
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Definition
| There is nothing special. Reed Sternberg Cells are hard to find. Instead, we have L& H variants which have multi-lobed nucleus resembling a popcorn kernel ("popcorn cell") |
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Term
| What is the background that the cells in nodular lymphocyte Hodgkin's are set in? |
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Definition
| A follicular dendritic meshwork that attracts cytokines and chemokines |
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Term
| Nodular lymphocyte Hodkgin's is considered to be non-neoplastic due to the absence of what 2 types of cells? |
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Definition
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Term
| What antigens and markers are present in Nodular Lymphocyte Hodkgin's? |
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Definition
| CD45, CD20, OCT2/BOB1 (stain like B cells), lack the classical CD 15 and 30 markers present in CHL |
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Term
| To what is the typical nodular pattern of growth in Nodular Lymphocyte Hodgkin's due to? |
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Definition
| Presence of expanded B-cell follicles, IgH genes undergoing somatic hypermutation (modification that occurs only in germinal center B cells) |
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Term
| What is the prognosis for individuals with Stage I/II nodular lymphocyte Hodgkin's? |
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Definition
| 80% of individuals have a median survival of at least 10 years. But, there is frequent relapse potential. |
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Term
| What is the age distribution in Classical Hodgkin's Lymphoma? |
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Definition
| There is bimodal age distribution (15-35) |
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Term
| What disease increases the risk of contracting CHL? |
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Definition
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Term
| What are the two lymph nodes most commonly involved in CHL? |
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Definition
| Cervical and Mediastinal (75% and 60%, respectively) |
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Term
| What are Reed-Sternberg Cells, and what functions do they serve? |
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Definition
| Reed-Sternberg Cells release factors that induce the accumulation of reactive lymphocytes, macrophages, and granulocytes, which typically make up greater than 90% of the tumor cellularity |
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Term
| What strain of EBV is associated with CHL in developing nations? |
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Definition
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Term
| What is the standard course of treatment for CHL? |
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Definition
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Term
| What subtype of CHL is the most common? |
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Definition
| Nodular Sclerosis- 70% of CHL cases |
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Term
| What type of RS cells are present in Nodular Sclerotic CHL? |
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Definition
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Term
| What are the gender and age distribution values for Nodular Sclerotic CHL? |
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Definition
| M:F is equal, and 18-34 is the age distribution |
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Term
| What is the geographic locality of Nodular Sclerotic CHL? |
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Definition
| More common in developed countries |
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Term
| Which subset of CHL has a high incidence of EBV and is more common in developing countries? |
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Definition
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Term
| What is the growth pattern for Mixed Cellular HL? |
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Definition
| There is diffuse efacement by a heterogenous cellular infiltrate, including everything / little nodular sclerosis/ no capsule formation |
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Term
| How common is EBV and B symptoms in Lymphocyte-Rich HL? |
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Definition
| EBV in 30-50% of such cases; due to proliferation of reactive lymphocytes, B symptoms not found |
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Term
| In Lymphocyte Depleted CHL, how are the RS cells unusual? |
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Definition
| The RS cells are infected with EBV in 95% of cases, and there is little cytokine/chemokine production; there is also an abundance of pleomorphic variants of RS cells |
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Term
| What are the common sites of involvement in Lymphocyte Depletion HL? |
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Definition
| Retroperitoneal lymph nodes, abdomen, bone marrow, peripheral nodes uncommon |
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