Term
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Definition
EFV/TDF/FTC
TDF should be used with caution in patients with renal insufficiency |
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Term
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Definition
ATV/r + TDF/FTC
DRV/r + TDF/FTC
TDF should be used with caution in patients with renal insufficiency
ATV/r should not be used in patients who require >20mg omeprazole equivalent per day. (Refer to table) |
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Term
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Definition
RAL + TDF/FTC
TDF should be used with caution in patients with renal insufficiency |
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Term
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Definition
LPV/r (BID) + ZDV/3TC (NOT Truvada)
EFV should not be used during the first trimester of pregnancy or in women of childbearing potential trying to conceive or not using effective and consistent contraceptive. |
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Term
Alternative
(comments on..)
EPV + ABC/3TC
RAL/TDF/FTC
RAL + ABC/3TC |
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Definition
Use RPV with caution in patiens with pretx HIV RNA >100,000 copies/mL
use of PPI is CONTRAINDICATED with RPV
no ABC in patients with HLA-B 5701
use ABC with caution in patients with known high risk of HIV RNA >100,000 copies/mL
Once daily LPV/r is not recommended in pregnant women |
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Term
Acceptable...
EFV + ZDV/3TC
NVP + (TDF/FTC) or (ZDV/3TC)
LPV/r +ZDV/3TC**
MVC + ZDV/3TC |
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Definition
NVP....
-should not be used in patients with mod to severe hepatic impairment
-should not be used in women with pre-ART CD4 count >250 etc...
USe NVP and ABC together with caution because both can cause HSRs withing first few weeks of therapy
ZDV can cause bone marrow suppression, lipoatrophy, amd rarely lactic acidosis with hepatic steatosis
LPV/r (BID) + ZDV/3TC is the preferred regimen for pregnant women
MVC - Perform tropism testing before initiation of therapy with MVC. Can be considered in patients who have only CCR5-tropic virus. |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
most renally eliminated...dose adj.
(ABC -alc. dehydrogenase)
(AZT- glucuronidation)
Food restrictions minimal
(ddI on ES)... but if w/ TDF then doesn't matter |
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Term
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Definition
| Lactic Acidosis with hepatic steatosis |
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