Term
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Definition
retrovirus
reverse transcriptase
carries its own protein
goes from RNA to DNA
has its own integrase and protease-enzymes for HIV |
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Term
| steps in viral replication |
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Definition
recognition of appropriate receptors
attachment to target cells
internalization of viral core
reverse transcriptase RNA-DNA
DNA replication
integration
actuation and viral replication |
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Term
| consequences of infection |
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Definition
number of viruses increases
number of host cells decreases-causes cell aptoptosis
host is permanently infected with cells containing integrated HIV provirions
loss of T4 cells leads to progressive immune suppression-T-helper cells |
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Term
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Definition
| less than or equal to 200 T4 cell count |
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Term
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Definition
6-12 weeks
time between infection and when the body starts making antibodies |
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Term
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Definition
elisa:screening test-high false positives
western blot: confirmatory test
incubation time-15 years + |
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Term
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Definition
acute retroviral syndrome
-negative antibody test
-flulike symptoms
asymptomatic infection
-positive antibody test
persistent generalized lymphadenopathy
-positive antibody test
-lymphadenopathy-> 1cm diameter at 2 or more extra-inguinal sites for more than 3 months |
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Term
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Definition
formerly: AIDS related complex (ARC)
usually a positive antibody test
examples of conditions:
-oropharyngeal candidiasis
-vulvovaginal candidiasis
-cervical dysplasia
-constitutional symptoms-fever, diarrhea
-oral hairy leukoplakia
-herpes zoster
-pelvic inflammatory disease
-peripheral neuropathy |
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Term
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Definition
Full blown AIDS
once in category C person will remain
positive antibody tests
AIDS-defining conditions
-pneumocystis carinii pneumonia
candidiasis of bronchi, trachea, or lungs
-cytomegalovirus (CMV) disease
-CMV retinitis (with loss of vision)
-herpes simplex
-mycobacterium tuberculosis infection
-recurrent pneumonia
-toxoplasmosis of the brain
-salmonella septicemia
-coccidioidmycosis
-cryptosporidiosis
-histoplasmosis
-isosporiasis
malignancies
-kaposi sarcoma
-invasive cervical cancer
-lymphomas-non-hodgkin
neurologic manifestations
-HIV-related encephalopathy (including AIDS ------dementia complex
-progressive multifocal leukoencephalopathy
HIV wasting syndrome |
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