Term
|
Definition
| Fusion Inhibitor: Binds & blocks GP41 |
|
|
Term
|
Definition
Entry inhibitors = CCR5 antagonists
*Need trophic assay* |
|
|
Term
|
Definition
NRTI: Nucleoside/nucleotide analogue Reverse Transcriptase Inhibitors
*fatal allergic rxn (HLA test)*
*SE: Mitochondrial toxicity* |
|
|
Term
|
Definition
NRTI: Nucleoside/nucleotide analogue Reverse Transcriptase Inhibitors
*SE: Mitochondrial toxicity* |
|
|
Term
|
Definition
NRTI: Nucleoside/nucleotide analogue Reverse Transcriptase Inhibitors
*SE: Mitochondrial toxicity* |
|
|
Term
|
Definition
NRTI: Nucleoside/nucleotide analogue Reverse Transcriptase Inhibitors
*SE: Mitochondrial toxicity* |
|
|
Term
|
Definition
abacavir + lamivudine
NRTI: Nucleoside/nucleotide analogue Reverse Transcriptase Inhibitors
*SE: Mitochondrial toxicity* |
|
|
Term
|
Definition
emtritabine + tenofovir
NRTI: Nucleoside/nucleotide analogue Reverse Transcriptase Inhibitors
*SE: Mitochondrial toxicity* |
|
|
Term
|
Definition
NNRTI: bind allosterically and block action of RT
*Major CYP3A4 Inducers* |
|
|
Term
|
Definition
NNRTI: bind allosterically and block action of RT
*Major CYP3A4 Inducers* |
|
|
Term
|
Definition
| Integrase inhibitor: Blocks enzyme (integrase) that introduces viral DNA into the genome |
|
|
Term
|
Definition
Protease inhibitor: Inhibits the viral protease which cuts the viral proteins into usable sizes
*CYP3A4 Inhibitors* |
|
|
Term
|
Definition
Protease inhibitor: Inhibits the viral protease which cuts the viral proteins into usable sizes
*CYP3A4 Inhibitors* |
|
|
Term
|
Definition
Protease inhibitor: Inhibits the viral protease which cuts the viral proteins into usable sizes
*CYP3A4 Inhibitors* |
|
|
Term
|
Definition
Protease inhibitor: Inhibits the viral protease which cuts the viral proteins into usable sizes
*CYP3A4 Inhibitors* |
|
|
Term
|
Definition
“boosted lopinavir”= lopinavir + ritonavir
Protease inhibitor: Inhibits the viral protease which cuts the viral proteins into usable sizes
*CYP3A4 Inhibitors* |
|
|
Term
|
Definition
| Triple Combo: efavirenz + emtricitabine + tenofovir |
|
|
Term
| What are the side effects for all HIV antivirals? |
|
Definition
Metabolic syndrome:
o Lipodystrophy (changes in fat distribution) buffalo hump & paunch
o Glucose intolerance/diabetes
o CV disease (↑MI rish by 2x)
Bone problems:
o Osteonecrosis (bone cell death)
o Osteoporosis (brittle bones) |
|
|
