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Histology Block-2 Respiratory
AUC
30
Histology
Graduate
02/09/2011

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Term
General Organization of Air-conducting Passages
Definition
Mucous membrane:
Epithelium-type varies
lamina propria - fibro-elastic ct. contains bvs, glands, lymph

Submucosa
mucous membrane rests on submucosa which is attached to a semi-rigid wall of muscle, bone or cartilage
Term
Respiratory Epithelium
Definition
pseudostratified ciliated columnar with goblet cells.

Hundreds of cilia extend from cell surface.
Term
Cilia
Definition
Cilia contain a central axoneme made of microtubles.

Arranged in 9 doublet circle with pair of singlet in middle.

Beat at 20 strokes per second.

Mucus moved towards pharynx
Term
Olfactory Epithelium
Definition
Pseudostratified columnar.

3 types of cells and one gland
Supporting(sustentacular) cells

Basal Cells

Olfactory(sensory) Cells

Glands of bowman
Term
Supporting(sustentacular) Cells
Definition
Supporting(sustenacular) cells
Tall cylindrical cells. broad apex. narrow base.
Posses many microvillie. pigment granules yellow-brown
Term
Basal Cells
Definition
Single layer of small cells, between bases of supporting cells

Can differentiate into sensory cells
Term
Olfactory(sensory) cells
Definition
Central Nucleus - apical dendrite.

Attach to supporting cells by junctional complexes

Olfactory vesicle - bulblike extension from which cilia protrude.

6-8 Cilia non motile. sensory receptors.

Axon arises from basal side passses underyling lamina propria and enters olfactory nerve
Term
Glands of Bowman
Definition
Within lamina Propria(loose ct( of olfactory epithelium.

Serous glands that relase watery secretion onto surface.

acts as solvenet for odoriferous substances

Mositen surface of epithelium

Wash away remains of stimulating substance
Term
Nasal Venous Sinuses
Definition
below olfactory epithelium.

Cover the middle and inferior turbinate bones(conchae)

lamina propria contains venous sinuses

warm inspired air
Term
Nasopharynx
Definition
Stratified squamos epithelium or Respiratory epithelium
Term
Pharyngeal Tonsil(Adenoids)
Definition
mass of lymphatic tissue in roof and posterior wall of nasopharynx.

In lamina propria. Resembles palatine tonsil

more diffuse and epithelum forms folds

adenoids are infected and obstruct passageway.
Term
Larynx
Definition
Connects pharynx and trachea.
Wall is kept from collapsing by cartilage
permits only air into lower respiratory

respiratory epithelium except vocal cords
Term
Vocal Cords
Definition
Part of larynx.

folds of mucous membrane from each side.

cause lumen of larynx to be silt-like

Vocal cords are covered by stratified squamous. Contain CT, Muscle and elastic tissue.
Term
Trachea
Definition
Connects larynx to bronchi

4 layers:
Mucosa
Submucosa
Cartilage
Adventitia
Term
Trachea Mucosa
Definition
respiratory epithelium on thick basement membrane
Term
Trachea sub mucosa
Definition
loose areolar CT
many mixed and serous glands
Term
Trachea Cartilage
Definition
20 C-shape hyaline cartilage rings stacked

C opening is posteriorly
Smooth muscle connects opening

contraction of muscle reduces diameter of trachea.

fibroelastic CT and glands fills spaces between cartilage rings
Term
Trachea Adventitia
Definition
Loose fibroelastic CT. Vessels and Nerves
Term
Bronchi
Definition
Mucosa - respiratory epithelium. Folded due to contraction.

Submucosa: Loose CT rich in elsatic fibers. Layer of smooth muscle. Seromucous and mucous glands outside muscle.

Caritlage. Irregular shaped plates that completely surround bronchus weblike. CT with elastic fibers holds plates together.
Term
Bronchioles
Definition
Less then 1 mm in diameter.

No cartiage, no glands, little CT

Prominent layer of smooth musclP
Term
Large Bronchioles
Definition
lined with ciliated columnar epithelum containing goblet cells.
Term
Small(terminal) bronchioles
Definition
ciliated cuboidal epithelum without goblet cells.

Cilia prevent smaller bronchioles from becoming occluded by mucous.

Clara Cells
Term
Clara Cells
Definition
found in terminal bronchioles.

secretory cells with no cilia

secrete material that lines bronchiolar lumen includes glycosaminoglycans.

Detoxyfing harmful substances

Can differitiate into ciliated and non ciliated cells
Term
Respiratory Bronchioles
Definition
No goblet cells.
cuboidal ciliated epithelium

some smooth muscle

few alveoli extend from wall. hence respiratory
Term
Alveolar Ducts
Definition
thin tubes with discontinuous walls

many alveoli.

some bronchiolar characteristics:
cuboidal ep and smooth muscle
Term
Atria and Alveolar sacs
Definition
Atria - space between end of alveolar duct and alveolar sacs

Alveolar sacs - cluster of alveoli
Term
Inter-alveolar Septum
Definition
CT - reticular and elastic fibres

Capillaries are thicker then septum and bulge into lumen.

Type 1 and type 2 pneumocytes

pulmonary macrophages

basement membrane

Alveolar pores - prevents incomplete expansion due to bronchial obstruction(atelectasis) links alveoli
Term
Type I and II pneumocytes
Definition
Type I
Simple squamos connected by desmosomes
very think cytoplasm, only nuclei can be seen with L.M.

Type II(secretory epithelial)
Cuboidal cells between squamous cells
secretes phospholipid layer called surfactant.
Aids in elastic recoil and helps prevent collapse
Term
Pulmonary Macrophages
Definition
arise from, fibroblasts and migration of monocytes from blood

Vacuolated macrophages - foamy. contain lipid droplets. removing blood lipids.

Non-vacuolated
Phagocytize inhaled particulate matter. Carried up the bornchi in mucous. eliminated by swallowing
Term
Alveolar basement membrane
Definition
Type 1 pneumocytes many times basement membrane is fused between capillary and alveoli.
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