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Histology Block-2 Cardiovascular
AUC
25
Histology
Graduate
02/10/2011

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Cards

Term
Layers in wall of arteries
Definition
Tunica Intima
Tunica Media
Tunica Adventia
Term
Tunica Intima
Definition
Weibal-Palade bodies - factor 7. blood clotting

sub endothelial layer of loose ct and occasional smooth muscle

Endothelium - simple squamous on basal lamina.

internal elastic lamina. Layer of elastin, seperates intima from media.
Term
Tunica Media
Definition
Layers of circularly arranged smooth muscle and elastin.

Reticular fibers and proteoglycans lie between smooth muscle

outer border is external elastic lamina.
Term
Tunica Adventitia
Definition
Layer of CT with fibroblasts, longitudinally arranged elastic and collagen fibres

Merges with suurronding ct

limits vessels, holds in place. contains blood vessels and nerves
Term
Elastic Artery Tunica Intima
Definition
endothelial cells produce cytokines, lympkines growth factors, and other molecules that control vasodilation/constriction, coagulation, and seletive permilibility

Larger Intima then other vessels
Term
Elastic Tunica Media
Definition
50-60 concentric, fenstrated elastic lamellae. concentric layeres of smooth muscle between elastic lamellae.

nerves and blood vessels.
Term
Elastic Tunica Adventitia
Definition
thinner compared to muscular.

irregulary arranged collagen and elastic fibers.
Term
Muscular(distributing) Tunica Intima
Definition
subendothelial layer thin or absent,

Thiner compared to Elastic Arteries

internal elastic membrane, prominent wavy strucutre - due to smooth muscle
Term
Muscular Tunia media
Definition
mainly circularly arranged smooth muscle cells.

External elastic membrane not prominant.

Embedded in ct containing abundant collagen. few elastic fiberes
Term
muscular Tunica Adventitia
Definition
thicker compared to elastic arteries

Rich in ollagen and elastic arteries
Term
Age Changes in Arteries
Definition
At birth only endothelium and I.E.M.
(no subendotheliium)

grwoth factors released from endothelium attract smooth muscle.

Smooth muscle produces elastin, collagen, and ground substance.
Term
Arterioles
Definition
No Elastic tissue(lamina)

diameter less then 100um

Tunica media is main layer, 1-3 layers of circular smooth muscle.
regulates degree of pressure.(narrow lumen, thick muscular wall)

metarterioles control filling of capillaries(blood flow to organs)
Term
Cappillaries
Definition
Have endothelium and basal lamina(supporting layer of ct)
Term
Continuous Capillarie
Definition
CNS, Lung, muscles, and ct

endothelial cells have coomplete cytoplasm

lumen slightly larger then erythrocyte

many pinocytotic vesicles - fluid transport

held together by tight junction
Term
discontinuous capillaries(sinusoids)
Definition
liver, spleen, bone marrow

No continuous cytoplasm

lumen up to three times larger then normal capillaries.

gaps occur between endothelial cells,(larger then fenestrations)

basement membrane(basal lamina) is discountinuous or absent
Term
Fenestrated Capillareis
Definition
in renal glomeruli, endocrine, intestine, pancreas.

Have fenestrations(gaps in endothelium)
Term
perictyes
Definition
perivascular cells scattered around the outside of capillaries
- they have long cytoplasmic processes which extend around the blood vessel
- they may be phagocytic and have some contractile properties
- may differentiate into other cell types during growth or wound healing (muscle, fibroblasts)
Term
AV shunts
Definition
Bypass capillaries.

thick, muscular walls

numerous in skin, thermoregulation
Term
Venules
Definition
Post capillary Venules have no tunica media.

Histamine and serotonin cause extravastation of fluid and emigration of white blood cells
Term
Medium Veins
Definition
tunica adventitia is thickest coat.

tunica media thinner then artery of comparable size. circular arranged smooth muscle
Term
Large Veins
Definition
Term
Large Veins
Definition
adventitia thickest layer, ct and smooth muscle.

Media layer thinner then in smaller veins
Term
Vasa Vasorum
Definition
More abundant in veins then arteryes

Because - veins carry poorly oxygenated blood.

blood vessels in wall won't collapse
(lower pressure)
Term
Valves of Veins
Definition
- arranged to permit blood to flow toward the heart but not in the opposite direction
- most valves consist of two leaflets or flaps - i.e. folds of intima with central ct
- valves are numerous in veins of the extremities - generally absent in thorax and abdomen
- occur distal to entrance of tributaries
- proximal to each valve is a localized swelling or sinus
- Function: 1) - to help overcome the force of gravity by preventing backflow
2) - to prevent back pressure on capillary beds during muscle contraction - valves enable skeletal muscle to serve as a pump
Term
Layers of Heart
Definition
Epicardium
- layer on outer surface of heart
- mesothelium plus underlying connective tissue containing blood vessels and nerves

Myocardium
- cardiac muscle fibers with numerous b.v.'s between fibers
- myocardium of ventricles thicker than in atria

Endocardium:
4 layers:
1. endothelium
2. subendothelial layer of connective tissue
3. middle layer of dense connective tissue and smooth muscle cells
4. subendocardial connective tissue which is continuous with ct of myocardium
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