Term
| Where does the first stage of prenatal hematopoiesis take place? |
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Definition
| Cells originate from the mesoderm within blood islands or clusters of angiogenic cells |
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Term
| Where does the second stage of prenatal hematopoiesis take place? |
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Definition
| During the second month mesodermal cells migrate to the liver and it becomes the major site of hematopoiesis while the spleen becomes a secondary site. |
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Term
| What is the maturation of erythrocytes dependent on? |
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Definition
| The presence of erythropoietin, iron, folic acid, and vitamin B12. |
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Term
| What makes up the stroma of red bone marrow and what secretes these substances? |
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Definition
| The stroma is made up of fibroblasts which secrete the type I and III collagen that makes up the extracellular matrix. |
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Term
| During stem cell differentiation which cells are capable of self-renewal? |
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Definition
-Pluripotential stem cells
-progenitor stem cells |
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Term
| Where and by what cells are growth factors synthesized? |
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Definition
-Macrophages and fibroblasts in the bone marrow
-Epithelial cells of the sinusoids
-T lymphocytes |
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Term
| T/F. Both red and yellow bone marrow produce blood cells. |
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Definition
| False. Yellow bone marrow does not produce blood cells. |
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Term
| Where is erythropoietin produced and what is its function? |
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Definition
| Erythropoietin is synthesize by the renal interstitial cells (outer cortex) and functions to stimulate erythrocyte formation. |
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Term
| What factors help determine RBC production? |
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Definition
-erythropoietin
-iron
-folic acid
-vitamin B12 |
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