Term
| what is histamine inhibited by? |
|
Definition
H2 receptors
epinephrine
Beta ags
incr in cAMP |
|
|
Term
| how is histamine inactivated? |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Effect of Histamine on Cardio |
|
Definition
BP decrease
vasodilation (NO release)
HR INCREASE (H2)
edema |
|
|
Term
|
Definition
| H1 sm. mus contraction-->diarrhea |
|
|
Term
| Histamine effect on airway smooth muscle |
|
Definition
| bronchoconstriction H1 receptors |
|
|
Term
| This His rec. causes pain and itching |
|
Definition
|
|
Term
|
Definition
| diphenhydramine, dimenhydrinate, chlorphrniramine |
|
|
Term
| 2nd generation H1 rec antags |
|
Definition
| Loratadine, fexofenadine, desloratadine, cetirizine |
|
|
Term
| which H1 antag generation exhibits little CNS distribution? |
|
Definition
|
|
Term
| Which H1 antag has longer half life |
|
Definition
|
|
Term
| which generation exhibits fewer side effects unrelated to H1 blockade |
|
Definition
|
|
Term
| Clinical uses of Histamine |
|
Definition
Allergy
Motion sickness
nausea in pregnancy
sedation
*mastocytosis or basophilic leukemia* |
|
|
Term
|
Definition
excitation in children
*resembles atropine poisoning* |
|
|
Term
|
Definition
| cimetidine, ranitidine, famotidine |
|
|
Term
| Effect of H2 on cardiovascular |
|
Definition
| little to none (also gastric muscles) |
|
|
Term
| side effects of H2 antags |
|
Definition
gynecomastia in men
galactorrhea
reversible impotence
incr serum creatinine (cimet and rani) |
|
|
Term
| This drug causes blood dyscrasias |
|
Definition
|
|
Term
| what caution should be given to patients w/reduced kidney function? |
|
Definition
| prolonged effects of H2 antags |
|
|
Term
| Rate limiting step in Serotonin synth |
|
Definition
| OHation of L-tryp to 5 OH tryp |
|
|
Term
| This is diagnostic for carcinoid tumor |
|
Definition
|
|
Term
|
Definition
|
|
Term
| 5-HT2a effect on arteries and arterioles |
|
Definition
arteries: contract
heart: POSITIVE chonotropic effect
arterioles: dilate
PLATELET AGGREGATION |
|
|
Term
| Clinical use of sumatriptan, 5-HT ag |
|
Definition
|
|
Term
| clinical uses of Ergot alkaloids |
|
Definition
Migraine (caffeine boosts absorption)
postpartum bleeds (er. maleate) |
|
|
Term
|
Definition
obstruct vascular dz
collagen dz
pregnancy |
|
|
Term
| Histamine effect on venule |
|
Definition
|
|
Term
| These agents inhibit histamine "release" |
|
Definition
|
|
Term
| on what receptor specifically does sumatriptan act |
|
Definition
|
|
