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HHD Pulmonary Tests Chapter 10
lecture notes
50
Medical
Post-Graduate
04/06/2009

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Term
indications for pulmonary function tests
Definition
evaluation for known or suspected respiratory disease
monitoring of disease progression and response to treatment
preoperative pulmonary evaluation
establishment of disability
early detection of COPD in smokers
Term
types of PFTs
Definition
spirometry
lung volume
diffusing capcity
arterial blood gas
Term
capacity is a combination of two or more
Definition
volumes
Term
tidal volume
Definition
volume inhaled or exhaled in each breath during quiet breathing
Term
inspiratory reserve volume
Definition
maximal volume of air inhaled fromt eh end of quiet inpiration
Term
expiratory reserve volume
Definition
maximal volume of air exhaled fromt eh end fo quiet epiration
Term
residual volume
Definition
volume that remains in lungs after maximal exhalation
Term
total lung capacity
Definition
vt+irv+erv+rv
Term
vital capacity is ____ or total lung capcity
Definition
75 percent
tidal volume +irv+erv
Term
functional residual capacity
Definition
ERV+RV (40 percent of total lung volume)
Term
inspiratory capcity
Definition
vt+irv (60 percent of tlc)
Term
spirometry
Definition
llows one to measure expiratory flows and any volume capcity that doesn't include RV (RV, TLC, FRC)
Term
reference values in spirometry are adjusted for
Definition
age, sex, race and height
Term
reproducibility of spirometery
Definition
should not vary more than 5 percent day, 12 percent week to week adn 15 percent year to year
Term
FEV1
Definition
decliens with increasing age at 20-30 ml a year
50-80 ml yr for a smoker
Term
forced expiratory volume
Definition
in the first secod of a forced vital capcity maneuvver
Term
peak expiratory flow rate
Definition
maximal force flow achieved buring an fvc maneuver
Term
fef25075
Definition
mean forced expiaratory flow during hte middle half of a fvc maneuver
Term
maximal voluntary ventilation
Definition
maximal amount of air expired in 12-15 sconds during repititve maximal inspiratory and expiratory efforts and extraploated to the minute.
Term
measurement of FRC
Definition
helium diulationa nd nitrogen washout as well as body plethysmography
Term
measurment of diffusing capacity
Definition
efficiency of gas transfer from mouth to alveolar capillary hemoglobin

reflects sufrace area available for gaas transfer as well as pulmonary red blood cells
thickness is les simporant
Term
reduction in diffusing capacity
Definition
reduced in emphysema, pulmonary fibrosis, sarcodosis, pulmonary edema, anemia
Term
increase in diffusing capacity
Definition
polycythemia, alveolar hemorrhage, early heart failrue
Term
maximal inspiratory pressure
Definition
greater than 50 -75 cm water in normals
Term
maximal expiratory pressure
Definition
greater than 80-100 cm water in normals
Term
what reduces the maximal pressures?
Definition
neuromuscular disease and patieents with respiratory muscular fatigue
Term
minimum and maximum
Definition
Term
obstructive lung disease
Definition
reduces expiratory flows
Term
obstructive lung disease
Definition
deceras in expiratory flows
decrease in FEV1 out of porportion to decreasein FVC
loss initially

TLC is normal or increased due to hyperinflation
Term
examples of obstructive lung disease
Definition
asthma
emphysema
Term
examples of obstructive lung disease
Definition
asthma
emphysema
Term
restrictive lung disease
Definition
intrinsic, parenchymal disease or extrinsic, extra-parenchymal disease

decreased expiratory flows, normal as a ufunction of volume

decreased tlc
Term
examples of restrictive lung disease
Definition
pulmonary fibrosis, penumonia, neuromuscular disease kyphoscolosis.
Term
pulmonary vascular disease
Definition
increased pulmonary aretery pressures
decreased diffusing capacity
spriometry and lung volumes typically normal
Term
example of pulmonary vascular disease
Definition
primar or secondary pulmonary hypertension, embollism, vasculitis
Term
disorders or respiratory drive
Definition
abnormal control of breathing
sprometery and lung volumes typically normal
Term
examples of disorders of respiratory drive
Definition
central sleep apnea, Cheyenne Stoeks respiration
Term
upper airway obstruction
Definition
fixed obstruction, tracheal stricture
variable obtruction tracheal tumor
Term
reduced FEV1/FVC is daignostic for
Definition
obstructive
Term
reducted FVC with normal ration
Definition
restriction
Term
reduced TLC
Definition
resitriction
Term
reduced FVC and ratio
Definition
severe obstruction or mixed obstruction
Term
positive bronchodilator
Definition
asthma
maybe OPD
Term
increased lung volumes
Definition
emphysema
large volumes of isoflow and preseved oxygenation at rest
Term
chronic bronchitis
Definition
smooth concavity on flow volume loop
normal or icnreased lung vlumes
preserved diffusion and resting hypoxemia
Term
parenchymal causes of restriction
Definition
low TLC reduced diffusion and evidence of increased elastic recoil
Term
extraparencymal
Definition
low tlc
normal diffusion
Term
low Pimax
low Pemax
Definition
inspiraotry mucle weakness
expiratory muscle weakness
Term
FRC increase
FRC decrease
Definition
ankylosing spndylitis
kyphoscolosis
Term
abnormal diffusion
abnormal gas exchange
Definition
pulmonary vascular disease
severe OSA synderome, hypoventilation, other disorders of respiratory drive
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