Term
|
Definition
| [Collagen I] weak bones that fracture easily |
|
|
Term
| Ehlers-Danlos syndrome, type IV |
|
Definition
| [Collagen I] fragile skin and blood vessels, hypermobile joints, bowel or large arteries can spontaneously rupture |
|
|
Term
|
Definition
| [Collagen IV] progressive nephritis, hearing loss, ocular lesions |
|
|
Term
| dystrophic epidermolysis bullosa |
|
Definition
| [Collagen VII] separation of dermis from dermis (severe blistering) |
|
|
Term
| Congenital muscular dystrophy |
|
Definition
| [Merosin (α-Laminin 2)] defective or missing |
|
|
Term
| Duchenne muscular dystrophy |
|
Definition
| mutation affecting dystrophin |
|
|
Term
| junctional epidermolysis bullosa |
|
Definition
| [Laminin 5 defect] skin blisters between epidermis and dermis |
|
|
Term
| arthritis, MS, tooth decay, cardiovascular disease, COPD, cancer metastasis |
|
Definition
| Excessive or innapropriate ECM degradation |
|
|
