Term
| Factors in cryoprecipitate |
|
Definition
|
|
Term
|
Definition
| Epistaxis, superficial bleeding and mucosal bleeding |
|
|
Term
| Treatment for vWF deficiency |
|
Definition
| DDAVP/desmopressin or replacement by infusion of cryo or concentrated factor VIII |
|
|
Term
| Dosing and how long DDAVP acts |
|
Definition
0.3 micrograms/kg IV over 15-20 minutes.
Improved platelet adhesion in 30 minutes, lasts 4-6 hours |
|
|
Term
|
Definition
| Hyponatremia, mostly in kids |
|
|
Term
| Steps in platelet activation |
|
Definition
| Prothrombin becomes thrombin, thrombin (factor IIa) activates platelet; exposes binding sites for fibrin |
|
|
Term
| Role of Thromboxane A2 and ADP in platelet activation |
|
Definition
| Both are produced by active platelet and they accelerate activation of nearby platelets |
|
|
Term
|
Definition
| Potent vasoconstrictor, promote platelet aggregation |
|
|
Term
|
Definition
| promotes platelet "stickiness", plavix is antagonist |
|
|
Term
| Name of binding site for fibrin on platelet |
|
Definition
|
|
Term
| Medications that inhibit GPIIb3a binding site |
|
Definition
| Reopro (irreversible); integrellin & aggrestat (reversible) |
|
|
Term
| Treatment for GPIIb3a binding site inhibitor drugs |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Regional anesthesia affect on platelet aggregation |
|
Definition
|
|
Term
| What is the most common acquired blood clotting defect? |
|
Definition
| Inhibition of cyclo-oxygenase production by aspirin or NSAIDS. |
|
|
Term
|
Definition
|
|
Term
| What is the rate limiting step in arachadonic acid conversion? |
|
Definition
|
|
Term
|
Definition
| Acetylation of cyclo-oxygenase |
|
|
Term
| How does aspirin reduces pain? |
|
Definition
| Preventing production of prostaglandins |
|
|
Term
| How does aspirin increase bleeding? |
|
Definition
| Blocks production of thromboxane A2 |
|
|
Term
| For patients on aspirin how long do you delay elective surgery? |
|
Definition
|
|
Term
| For patients on aspirin how do you treat them in an emergent surgery? |
|
Definition
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