Term
| What is the adhesion process of the platelet plug formation? |
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Definition
| binding of platelet surface GP1B to vWF |
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Term
| What forms a bridge between platelets? |
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Definition
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Term
| What is released from activated platelets to aid in recruitment for clot formation? |
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Definition
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Term
| What is the primary physiologic event that initiates clotting? |
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Definition
| exposure of tissue factor at wound site |
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Term
| Which is the only procoagulant that is not synthesized in the liver and where is it synthesized? |
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Definition
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Term
| What are seven control mechanisms that modulate hemostasis? |
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Definition
1) Antithrombin III-Heparin sulfate system
2) Protein C/S thrombomodulin system
3) Tissue Factor Pathway inhibitor
4) Prostacyclin (PGI2)
5) Nitric Oxide
6) Ecto-ADPase (CD39)
7) Fibrinolysis |
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Term
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Definition
| converts plasminogen to plasmin which facilitates local fibrinolysis |
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Term
How is each pathway regulated?
1) TF/Factor VIIa
2) Thrombin
3) t-PA activity
4) Thrombin and plasmin |
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Definition
1) TFPI/factor Xa complex
2) Protein C and S
3) plasminogen activator inhibitor 1
4) antithrombin III for thrombin regulation and alpha2 antiplasmin to regulate plasmin |
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Term
| How long do platelets survive and what is there half life? |
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Definition
| surive for 8.5-10 days and half life of 4 days |
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Term
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Definition
| intrinsic coag system (before factor X activation) |
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Term
| What does the PT measure? |
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Definition
| extrinsic system (coumadin) |
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Term
| D-dimer is a specific measure of intravascular fibrin deposition and plasmin degradation characteristic of what? |
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Definition
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Term
| Mixing study results tell you what? |
|
Definition
If mixture corrects clotting abnormality - factor deficiency
Still has prolonged clotting time- inhibitor is present |
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|
Term
| What are the 4 vitamin K Dependant clotting factors? |
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Definition
| factor VII, Factor IX, Factor X, prothrombin |
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