Shared Flashcard Set

Details

Hemostasis and Bleeding disorders
Platelets and proteins involved in clot formation and pathogenic deficiencies
8
Pathology
Professional
10/09/2011

Additional Pathology Flashcards

 


 

Cards

Term

Intrinsic Factors

- name them

Definition

Factor 8, 9, 11, 12, and kininogen-prekallikrein complex

 

 

Term

Extrinsic factors

- name them

Definition
Factor 7
Term

Common pathway

- in order

Definition

Factor 10 activated by 9+8 (intrinsic) or 7 (intrinsic)

 

Factor 10 activates Factor 2 (Thrombin) along with factor 5

 

Thrombin converts fibrinogen to fibrin

--> also feedback and activates factors 5 and 8

Term

Thrombin

- functions

Definition

Functions:

- cleaves fibrinogen to fibrin

- activates factor 13 to stabilize fibrin

- acts on platelets to stimulate aggregation via activation of arachidonic acid release

- activates coagulation inhibitor, protein C

Term
Vitamin K dependent clotting factorss
Definition

Factors 2, 7, 9, 10, C-protein, S-protein 

--> all hepatic

Term

Protein C

- actions

Definition

Action:

- inhibits activation of Factor 5a and 8a

Term

t-PA

- function

Definition

Function:

- activates plasmin which dissolves factors 1, 5, 8

Term

Antithrombin-3

- function

Definition
cleaves factor 9, 10, thrombin
Supporting users have an ad free experience!