Term
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Definition
| Promotes endothelial growth and development |
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Term
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Definition
| promotes hematopoiesis; critical for CFC-B development |
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Term
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Definition
- Promotes CFC-NM mitosis and differentiation
- Neutrophil
- Monocyte
- Dendritic cell |
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Term
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Definition
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Term
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Definition
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Term
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Definition
- promotes dendritic cell development
-Pre-DC -> Immature DC |
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Term
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Definition
| - Immature dendritc cell (langerhans) -> Mature dendritic cell |
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Term
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Definition
| - With IL3, IL 6 and SCF PHSC -> CFC-GEMM |
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Term
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Definition
| Pro T/NK -> NK (with IL 12) or to T-cell (with IL 6) |
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Term
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Definition
With IL-1 and IL-6
PHSC -> CFC GEMM and CFC Ly |
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Term
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Definition
CFC-GEMM -> Basophil
CFC-ly-> (with IL-7) B cell -> Plasma cell
CFC-NM -> (with GM-CSF) -> dendritic cell |
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Term
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Definition
CFC GEMM -> Eosinophil
- B-cell -> Plasma cell |
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Term
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Definition
With Il-3 and Il-1
PHSC -> CFC-GEMM
also B cell -> plasma cell (with IL 4 and IL 5) |
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Term
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Definition
PHSC -> CFC-LY (with IL-3)
CFC-B -> pro B |
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Term
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Definition
| T/NK -> (With IL 2) NK cell |
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Term
IL 12 in THx repsone?
Which Thelper response?
Which cell type secretes it?
Function? |
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Definition
-Th1 pathway
- secreted by APC
- commit Th0 -> Th1 |
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Term
IL 18 in THx repsone?
Which Thelper response?
Which cell type secretes it?
Function? |
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Definition
- Th1 pathway
- APC secretes it
- works in concert with IL12, enhancing it's effect of committing Th0->Th1 |
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Term
INF-γ in THx repsone?
Which Thelper response?
Which cell type secretes it?
Function? |
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Definition
- Th1 pathway
- T helper secretes it
- activates macrophages
- supresses Th2 or Th17 response |
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Term
IL-2 in THx repsone?
Which Thelper response?
Which cell type secretes it?
Function? |
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Definition
- Th1 pathway
- Th1 cell secretes it
- Helps Th1 cell proliferation and growth |
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Term
IL 21 in THx repsone?
Which Thelper response?
Which cell type secretes it?
Function? |
|
Definition
In Th1 pathway, secreted by Th1 cell
- activates CD8 cytotoxicity
In Th2 pathway (absence of INF-y) secreted by Th2 committed cell
- stimulates B cell proliferation |
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Term
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Definition
| - increases APC presenation |
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Term
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Definition
- fever in concert with IL6
- also activates B cells |
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Term
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Definition
| - recruitment of neutrophils |
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Term
| TNF-α - 3 main functions as proinflammatory cytokine |
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Definition
- macrophage recruitment
- endothelial cell homing and adheison
- growth of vasculature |
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Term
IL-10 in THx repsone?
Which Thelper response?
Which cell type secretes it?
Function? |
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Definition
-Th2 pathway
- secreted by Th2 cell
- potent supressor of Th1/TIMMI response |
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Term
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Definition
proinflammatory cytokine released by adipocytes
- increases TNF-alpha, IL1, IL6 |
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Term
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Definition
| Proinflammatory cytokine produced by adiopocytes, also pro angiogenic |
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Term
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Definition
anti-inflamatory cytokine produced by adipocytes
- decreases TNF-alpha |
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Term
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Definition
Macrophage inhibitory cytokine - produced by adipocytes and is anti-inflammatory
- major stimulator of adiponectin |
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Term
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Definition
| anti-inflammatory cytokine of adipocytes |
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Term
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Definition
- proinflammatory macrophage derived cytokine that acts in adipose tissue
- strongly chemotactic for monocytes and macrophages |
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Term
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Definition
- proinflammatory macrophage derived cytokine
- direct antagonist of adiponectin and promotes TNF-alph and IL 6 production |
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