Term
ALL:
- Who gets it
- Histo features
- Lab findings |
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Definition
Who: kids or teens
Histo: bone marrow replaced with lymphoblasts
Labs: TdT+, CALLA+ |
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Term
SLL/CLL:
- Who gets it
- Histo features
- Lab findings |
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Definition
Who: elderly
Histo: smudge cells on peripheral smear
Lab: warm antibody hemolytic anemia |
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Term
Hairy cell leukemia:
- Who gets it
- Histo features
- Lab findings |
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Definition
Who: elderly/adults
Histo: B cells with filamentous, hairlike projections
Lab: Stains TRAP positive |
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Term
AML:
- Who gets it
- Histo features
- Lab findings |
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Definition
Who: elderly/adults
Histo: myeloblasts on peripheral smear
Lab: M3 subtype has t(15;17) and responds to all-trans retinoic acid |
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Term
CML:
- Who gets it
- Histo features
- Lab findings |
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Definition
Who: age 30-60
Histo: increased neutrophils and basophils
Lab: Philadelphia chromosome (t[9;22], bcr-abl), also very low leukocyte alkaline phosphatase
(can transform into AML or ALL and present with blast crisis) |
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Term
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Definition
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Term
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Definition
| Burkitt's lymphoma (c-myc activations) |
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Term
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Definition
| Follicular lymphomas (bcl-2 activation) |
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Term
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Definition
| M3 type of AML (respondsive to all-trans retinoic acid) |
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Term
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Definition
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Term
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Definition
Mantle cell lymphoma
(translocation of cyclin D regulatory gene in old men, poor prognosis) |
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