Term
| Determines the life of a cell cycle |
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Definition
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Term
| Quiescent cells like Stem Cells |
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Definition
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Term
| Lasts 10-20 hrs while DNA is replicating |
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Definition
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Term
| Lasts 3 hrs, prep for mitosis |
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Definition
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Term
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Definition
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Term
| Time for ONE cell cycle (1/freq of cells division) |
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Definition
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Term
| Which cells have the shortest DT? |
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Definition
| -BM, GI epithelium and hair follicles |
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Term
| proportion of cells that can be killed by a tx |
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Definition
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Term
| recovery time (shorter DT=shorter recovery) |
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Definition
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Term
| combination therapy for breast CA |
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Definition
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Term
| A rescue treatment (you kill cells then rescue them with another drug) |
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Definition
| -MTX followed by Leucovorin |
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Term
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Definition
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Term
| causes of multiple drug resistance |
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Definition
-INC DNA repair, production of drug targets, drug efflux and inactivation of taget cells
-DEC activation of pro-drugs and DEC drug entry |
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Term
| A potential AE of Cyclophosphamide |
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Definition
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Term
| CarMUSTine and LoMUSTine are: |
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Definition
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Term
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Definition
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Term
| Of the platinum containing complexes, which is the safest/Worst? |
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Definition
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Term
| Neuro and renal toxicity is an AE of what? |
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Definition
| -Platinum containing cmps (end in --platin) |
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Term
| Free Radical Formation is the MOA of |
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Definition
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Term
| Class of drugs that act specifically on the S phase |
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Definition
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Term
| A widely used folic acid analog that binds to DHF and stops DNA synthesis. Used as a rescue tx with Leucovorin |
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Definition
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Term
| A last resort pyrimidine analog |
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Definition
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Term
| A pyrimidine analog good for COMBO therapies with leucovorin, cisplatin or MTX |
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Definition
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Term
| Txs AML but may cause Cerebellar Toxicity and Bone marrow suppresion |
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Definition
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Term
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Definition
| -Inhibit purine interconversion which stops DNA synthesis |
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Term
| Derived from Streptomycin, cell cycle non-specific |
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Definition
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Term
| MOA of Vincristine (and Vin--) and Paclitaxel |
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Definition
| -inhibits daughter cells from splitting in metaphase leading to APOPTOSIS |
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Term
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Definition
| -Peripheral Sensory Neuropathy |
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Term
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Definition
| -infxn, DM, HTN, fluid retention |
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Term
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Definition
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Term
| An estrogen receptor blocker other than tamoxifen |
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Definition
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Term
| AE of GnRH Agonists (Leuprolide and Goserelin) |
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Definition
| -gynecomastia, hot flashes, impotence |
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Term
| Aromatase inhibitors used to tx breast CA in post-menopausal women |
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Definition
| -Aminogluthethimide and Anastrozole |
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Term
| tx for Hodgkins Lymphoma (ABVD) |
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Definition
-Adriamycin
-Bleomycin
-Vinblastine
-Dacarbazine |
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Term
| Tx for Non-Hodgkins Lymphome |
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Definition
-Cyclophosphamide
-Adriamycin (hydroxydaunorubicin)
-Oncovin (vincristine)
-Prednisone |
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Term
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Definition
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Term
| cardio problems is an AE of what drugs? |
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Definition
| -doxorubicin, daunorubicin, |
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Term
| Pulmonary fibrosis is most likely caused by which of the following chemo agents |
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Definition
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Term
| Anti-tumor abx that is cell cycle specific (G2) |
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Definition
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Term
| an intercolator, forms free radicals, and inhibits topoisomerase |
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Definition
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Term
| sick building exposure would mostly likely be causes by |
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Definition
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Term
| a farmer with hematemesis and bloody stools would be due to |
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Definition
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Term
| AEs of heavy metal contaminants are MC a/w |
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Definition
| inhibition of enzyme activity by binding to enzyme sulfhydryl groups |
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Term
| if a pt is hypoxic, it's due to |
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Definition
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Term
| what part of the body is MOST SENSITIVE to chronic lead exposure |
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Definition
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Term
| if a worker is in a factory that makes hydrocarbon solvents the bad chemical causing leukocytopenia and aplastic anemia is |
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Definition
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Term
| toxic levels would cause twitching and eventual paralysis in the extremities |
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Definition
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