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Details

heme/onc pharm MOA
FirstAid 2010
10
Medical
Professional
03/27/2011

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Cards

Term
mtx
Definition
folic acid analog
inhib dihydrofolate reductase
Term
5-fu
Definition
pyrimidine analog
inhib thymidylate synthase
Term
6-mp, 6-tg
Definition
purine analog
decr de novo purine synth
Term
ara-c
Definition
pyrimidine antagonist
inhib DNA polymerase
Term
dactinomycin
Definition
intercalates in DNA
Term
doxorubicin (adriamycin), daunorubicin
Definition
free radical intercalate in DNA
Term
bleomycin
Definition
free radical breaks DNA
Term
cyclophosphamide, ifosfamide
Definition
covalently crosslink DNA
Term
nitrosoureas - carmustine, lomustine, semustine, streptozocin
Definition
cross BBB
Term
busulfan
Definition
alkylates DNA
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