Term
| LAP score (leukocyte acid phosphatase) |
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Definition
| determines between leukemoid reaction/acute infection/pregnancy |
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Term
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Definition
| detects abnormal nucleotide sequences and viral nucleic acid (Ebola/Marburg, Borreliosis) |
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Term
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Definition
| detects abnormal chromosomal arrangement |
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Term
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Definition
| quantitative measurement of gene expression |
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Term
| Pseudo Pelget-Huer Anomaly |
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Definition
| bilobed PMNs, acquired in myelodysplasia |
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Term
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Definition
| test for CD55/CD59 on surface (PIG-related proteins, PNH) |
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Term
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Definition
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Term
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Definition
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Term
| standard stains, MPO stains/non-specific esterases, flow cytometry, cytogenetics |
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Definition
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Term
| t(8;21), inversion 16, t(15;17), <60yo |
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Definition
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Term
| 5(-), 7(-), 11q23 abnormality, prior marrow disorder |
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Definition
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Term
| Flow cytometry for CD10/CD3/CD20 |
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Definition
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Term
| 2-10 yo, t(12;21), hyperdiploid (>50 chromosomes/cell) |
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Definition
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Term
| t(9;22), 11q23 abnormality |
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Definition
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Term
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Definition
| distinguishes monoclonal/polyclonal Igs, extensively kappa or lamda light chain, "M-spike band" in myeloma |
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Term
| Serum electrophoresis, urine electrophoresis, Xrays for lesions |
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Definition
| Tests for multiple myeloma, DO NOT DO BONE SCANS |
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Term
| Bone marrow biopsy, serum electrophoresis, viscosity (>4) |
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Definition
| tests for Waldenstrom's Macroglobulinemia |
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Term
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Definition
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Term
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Definition
| c-myc/IgH fusion (Burkitt lymphoma) |
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Term
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Definition
| Bcl-2/IgH fusion (follicular lymphoma) |
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Term
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Definition
| cyclin D1/IgH fusion (mantle cell lymphoma) |
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Term
| Hodgkin International Prognostic Index (HIPI) |
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Definition
| GASLAW- Gender (male), Anemia (hgb<10.5, albumin<4), Stage (IV), Lymphocytopenia (<8% or <600), Age (>45), WBC (>15K) |
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Term
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Definition
| single lymph node region (usually cervical) or single extralymphatic site |
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Term
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Definition
| two or more lymph nodes on same side of diaphragm -or- one lymph node region and contiguous extralymphatic site |
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Term
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Definition
| lymph nodes on both sides of diaphragm, may include spleen and/or limited contiguous extralymphatic organ or site |
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Term
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Definition
| disseminated involvement of one or more extralymphatic organs |
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Term
| biopsy, lumbar puncture, ki-67 |
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Definition
| tests for Burkitt lymphoma |
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Term
| biopsy of colon polyps/lymph nodes, cyclin D1 immunostaining |
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Definition
| tests for mantle cell lymphoma |
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Term
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Definition
| 0-lymphocytosis, 1-adenopathy, 2-splenomegaly, 3-anemia, 4-thrombocytopenia |
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Term
| Bone marrow biopsy, lymph node biopsy |
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Definition
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Term
| V-region mutation before malignancy |
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Definition
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Term
| Malignant before rearrangement, CD38/Zap70, 11Q(-), 17P(-) |
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Definition
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Term
| Marrow biopsy, TRAP stain, CD103 |
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Definition
| tests for hairy cell leukemia |
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Term
| Binbeck granule (HX body), LOH 9p/22q, CD15/S-100/HLA-DR/CD1a |
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Definition
| tests for Langerhans Cell Histiocytosis (Histiocytosis X) |
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Term
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Definition
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Term
| Marburg/Ebola virus (filovirus) |
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Definition
| ssRNA, negative sense, enveloped |
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Term
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Definition
| nonspecific, may or not be produced in EBV mononucleosis, never in CMV mononucleosis |
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Term
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Definition
| tests for antigen (CMV, Ebola/Marburg, schistosomiasis) |
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Term
| 2step PCR 238bp/154bp amplification |
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Definition
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Term
| PCR, IHC/culture of skin biopsy, antibody titer |
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Definition
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Term
| Group-specific antigens, type-specific antigens, Weill-Felix Reaction |
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Definition
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Term
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Definition
| antibody reaction to Proteus O polysaccharides, cross-reactive agglutination is positive for Rickettsia/Proteus |
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Term
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Definition
| intracytoplasmic colonies in vacuoles (ehrlichosis) |
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Term
| Serology, PCR, blood smear |
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Definition
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Term
| Culture, IFA/ELISA, silver stain, skin biopsy |
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Definition
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Term
| Factor V Leiden mutation, Lupus anticoagulant, Homocystine levels, Prothrombin G20210A mutation, Antithrombin III levels, Protein C levels, itssue factor C536T mutation |
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Definition
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Term
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Definition
| factor VIII,IX,XI,XII deficiency, intrinsic pathway disturbance, hemophilia |
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Term
| VIIIC activation/quantitation, vWF concentration, vWFRCA, multimer structure/molecular analysis |
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Definition
| test for Von Willebrand Disease |
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Term
| Thrombin formation, fibrinolysis, consumption of factors |
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Definition
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Term
| first thrombosis <50yo, thrombosis of hepatic/mesenteric/cerebral venules, recurrent/familial thrombosis, thrombosis during pregnancy/contraceptives, MI in female smokers <50yo |
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Definition
| reasons to test for thrombophilia |
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Term
| 4-fold increase in titer (antibodies persist, does not distinguish acute/chronic), direct fluorescence |
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Definition
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Term
| isolation from bubos, specific serology, culture on blood agar, Wayson's Stain for tiny rods |
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Definition
| tests for Yersinia pestis |
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Term
| titer >1:160 presumptive, definitive culture |
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Definition
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Term
| iodine-positive inclusions, ELISA/IF for antigens, high titer (can't determine acute/chronic), nucleic acid probes (high frequency false positives) |
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Definition
| tests for lymphogranuloma venereum (chlamydia) |
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Term
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Definition
| 1:1 mixture normal plasma and patient plasma, factor deficiency will be correct on PTT, inhibitors (Abs,drugs) block clotting and will maintain a prolonged PTT |
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Term
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Definition
| test for deficiency of Factors VIII,IX,XI,XII, Lupus inhibitor, Factor VIII,IX inhibitor |
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Term
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Definition
| deficiency of Factors VII,V,X, combined deficiency of Factors II,VII,IX,X, vitamin K deficiency, lupus inhibitor |
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Term
| increased aPTT/PT/bleeding time |
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Definition
| deficiency of fibrinogen, impaired cleaveage of fibrinogen to fibrin (heparin) |
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Term
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Definition
| deficiency of Factor VII, combined deficiency of Factors II,VII,IX, vitamin K deficiency |
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Term
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Definition
| test for platelet function, replaces bleeding time |
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Term
| Thrombocytopenia (non-genetic) |
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Definition
| due to drugs, chemo, radiation, benzene |
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Term
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Definition
| plasma exchange, cell removal, RBC exchange |
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Term
| ABO group, Rh type, antibody screen, viral markers, syphilis |
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Definition
| tests for transfusion donors |
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Term
| HIV antigen/NA, HBV antigen/antibody, HCV antibody/NA, HTLV I/II antibodies, syphilis, west nile virus, chagas disease, CMV |
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Definition
| infectious markers tested before transfusion |
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Term
| Whole blood (5wks), RBCs (6wks), Thawed FFP (1day) |
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Definition
| component products stored at 1-6C |
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Term
| Thawed cryoproducts (4h), platelets (5dy) |
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Definition
| component products stored at 20-24C |
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Term
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Definition
| resistance to APC cleavage, R506Q due to A5070G |
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Term
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Definition
| test for prothrombing (Factor II) mutation, two peaks indicates heterozygote |
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Term
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Definition
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Term
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Definition
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Term
| Cast on extremity (immobile), recent operation (gynecologic/orthopedic), medication (thalidomide), systemic disorders (AI hemolysis/nephrotic syndrome/lupus/cancer) |
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Definition
| reasons to NOT test for hypercoagulability |
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Term
| ATIII/mixing studies, protein C/S, FVL, Prothrombin 20210, homocystine levels, anticardiolipin antibodies, Factor VIII/IX levels |
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Definition
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