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Heme/Onc Exam 1 Proteins
Proteins, Genes, and Compounds for Heme/Onc exam 2
53
Medical
Professional
09/12/2011

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Term
CD45
Definition
leukocyte common antigen, differentially expressed during maturation of stem cells to HSCs
Term
kappa light chain
Definition
predominant form, rearranges first
Term
CD55/CD59
Definition
bound on surface to PIG
Term
JAK2
Definition
mutated in Polycythemia Vera, Essential Thrombocytosis, Myelofibrosis
Term
CD10
Definition
common acute leukemia antigen (ALL)
Term
Osteoclast Activating Factor
Definition
causes lytic bone lesions (multiple myeloma)
Term
Transthyretin/B2microglobulin/AA
Definition
proteins commonly causing amyloidosis
Term
CD30/CD15
Definition
markers on Reed-Sternberg cells (Hodgkin's)
Term
CD19/CD20/CD10
Definition
markers for Bcells (follicular lymphoma, Burkitt lymphoma)
Term
CD19/CD20
Definition
markers for B-cells (DLBCL, marginal zone lymphoma)
Term
c-Myc
Definition
causes proliferation (burkitt lymphoma)
Term
CD19/CD20/CD5
Definition
markers for Bcells (mantle cell lymphoma)
Term
CD19/CD20/CD5/CD23
Definition
markers for Bcells (small lymphocytic lymphoma)
Term
CD4
Definition
marker for Tcells/NKcells (mycosis fungoides)
Term
GM-CSF/IL-4
Definition
converts monocytes to dendritic cells
Term
TNFa
Definition
activates dendritic cells
Term
CD68
Definition
marker for histiocytic sarcoma/lymphoma
Term
CD15/S-100/HLA-DR/CD1a
Definition
markers for histiocytosis X
Term
c-kit/EGFRA
Definition
mutated in Mast Cell Infiltrates
Term
CD20
Definition
marker of Bcells, target of rituximab, essential for EBV infection
Term
CD8
Definition
marker on Tcells, elevated in EBV mononucleosis
Term
Protein C
Definition
cleaves factor Va/VIIa, complete deficiency is fatal, partial deficiency causes coumadin-induced skin necrosis/recurrent venous thrombosis, vitamin K dependent, infused for survival of septic shock
Term
Factor XIIIa
Definition
polymerizes fibrinogen
Term
Factors II, VII, IX, X
Definition
vitamin K-dependent factors
Term
Factor VIII
Definition
carried in plasma complexed with vWF
Term
vWF
Definition
adheres to exposed ECM around vessels, binds gpIb, synthesized in endothelium/megakaryocytes, stored in platelets, complexed with Factor VIII, cleaved to p176/p140
Term
gpIIbIIIa
Definition
causes platelets to adhere to each other
Term
Antithrombin III
Definition
irreversibly binds thrombin and other protease factors
Term
Platelet Factor 4
Definition
combines with heparin, resulting antigen responsible for HIT
Term
rifampin/barbituates/phenytoin/alcohol
Definition
induce CYP450, decrease effectiveness of warfarin
Term
MTHFR
Definition
mutated C677T or A1289C in hyperhomocystinemia
Term
Prothrombin (Factor II)
Definition
F2 G2010A mutation
Term
Factor V Leiden
Definition
R506Q (A4070G) mutation
Term
CYP2C9
Definition
sets rate (accumulation/elimination) of warfarin response
Term
VKORC1
Definition
set amount (concentration) of warfarin response, variants require decreased dosage
Term
CYP2C9 *1*1
Definition
rapid warfarin metabolizers, 5mg/day
Term
CYP2C9 *1*2/*1*3
Definition
intermediate warfarin metabolizer (2.5-2.7mg/day)
Term
CYP2C9 *2*2/*2*3/*3*3
Definition
poor warfarin metabolizers, 1.5-1.7mg/day
Term
CYP2C19
Definition
involved in both steps of clopidogrel conversion
Term
CYP2C19 *1/*1
Definition
extensive clopidogrel metabolizers
Term
CYPC19 *1*2/*1*3
Definition
intermediate clopidogrel metabolizers
Term
CYP2C19 *2*2/*2*3/*3*3
Definition
poor clopidogrel metabolizers
Term
CYP2C19 *17*17
Definition
ultrarapid clopidogrel metabolizers
Term
CYP2C19 *1
Definition
wild type form
Term
CYP2C19 *2
Definition
G681A, truncated protein
Term
CYP2C19 *3
Definition
G636A, truncated protein
Term
CYP2C19 *17
Definition
C806T/C3402T, increased translation
Term
tPa/uPa
Definition
activate plasminogen
Term
plasmin
Definition
digests clot
Term
PAI-1
Definition
stops tPa, from endothelial smooth muscle
Term
PAI-1
Definition
stops tPa, from endothelial smooth muscle
Term
Protein S
Definition
cofactor for Protein C, vitamin K dependent, bound and free forms, decreased during pregnancy
Term
Factor Xa
Definition
activates thrombin, set up by Factor Va
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