Term
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Definition
| production, differentiation and maturation of blood cells. MAintains and regulates the cellular population of the body's blood cells. |
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Term
| Where are blood cells created? |
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Definition
Bone Marrow (primarily)
Liver, Spleen, Lymph nodes, Thymus |
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Term
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Definition
| spongy, fatty substance inside bones. In the adult it produces ALL RBCs, 60-70% of WBCs and ALL platelets. |
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Term
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Definition
| Inside bone marrow are immature RBCs, WBCs and PLTs, once they are mature they are released into the blood. |
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Term
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Definition
| Blood cells begins as pluripotent stem cells, which can become any cell. As they mature the stem cells differentiate. |
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Term
| When do blood cells form in a fetus? |
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Definition
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Term
| Three stages of hematopoesis |
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Definition
Fetal Development
Childhood
Adulthood |
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Term
| In Fetal Development, what are the major organsof hematopoiesis? |
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Definition
Yolk sak, liver, spleen, bone marrow.
Other organs include: Thymus and Lymph Nodes. |
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Term
| First 2 Months of Fetal Development |
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Definition
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Term
| 2nd to 7th months of fetal development |
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Definition
| Liver and spleen take over the hematopoietic role, thymus and lymph nodes become active in cell production. |
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Term
| After 7 months in fetal development |
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Definition
| Bone Marrow assumes primary role. |
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Term
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Definition
| At Birth all marrow is red, it is highly cellular and active in blood cell production. |
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Term
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Definition
| Unspecialized cells waiting to be assigned a duty. The can differentiate into multiple types of cells. |
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Term
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Definition
| One differentiation of pluripotent stem cells. Can mature into RBCs, PLTs, Monocutes and Granulocytes |
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Term
| Changes in Cells as they Mature |
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Definition
Overall Size: Decreases as it matures
Cytoplasm: Color and amount
Granules: Color and Size
Nucleus: Chromatin pattern and shape
Nucleoli: Number
N/C Ratio (Nucleus to Cytoplasm) |
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Term
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Definition
| From Pluripotent SCs. Mature into B-Lymphocytes and T-lymphoctes. |
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Term
| What happens to Red Bone Marrow with age? |
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Definition
| tansformed into fat cells and becomes yellow. Yellow marrow is inactive. |
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Term
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Definition
| amount of cytoplasm in realtion to its size increases, color fades from deep blue, to a paler blue, due to a decrease in RNA as a cell ages. |
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Term
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Definition
| At first, granules are few and relatively non specific, as the cell matures, granuels increase in number and take on characteristics and functions. |
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Term
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Definition
| decreases in size, may transform in shape, usually lobed, chromatin pattern more coarse and clumped, Staining promorites change from lighter to darker, Nucleoli will gradually disappear. |
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Term
| What are the blood production sites in childhood? |
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Definition
| Iliac Crest, Sternum, Skull, Scapulae, Vertebrae & Ribs, Pelvic Bones, Long Bones |
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Term
| What are the blood production sites in adulthood? |
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Definition
| same sites in childhood, minus the long bones. |
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Term
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Definition
| Usually small in amount, N/C Ratio increased, Dark blue in color (high amounts of RNA), Primary granules reddish-purple and non specific. |
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Term
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Definition
| Increased Amount, N/C ration, Less blue in color(decreased RNA), Secondary, specific granules that vary in color. |
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Term
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Definition
| Round or oval, very large, occupies almost entire cell, Increased N/C ratio, Fine and delicate chromatin, reddish purple stain, 1 or more nucleoli. |
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Term
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Definition
| Smaller; may take on various shapes, usually lobed, decreased n/c ratio, coarse and clumped chromatin, blue purple stain, no nucleoli. |
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