Term
| what growth factors act on early erythroid progenitors? |
|
Definition
|
|
Term
| what growth factors act on BFU-E? |
|
Definition
| GM-CSF and IL4 (EPO to some degree on the late BFU-E) |
|
|
Term
| what is EPO's main action? |
|
Definition
| on CFU-E to stimulate conversion into pronormoblasts (differentiate into rbc) |
|
|
Term
| where does EPO come from? |
|
Definition
| juxtaglomerular body of the kidney |
|
|
Term
| what are the early factors responsible for regulating myelopoiesis? |
|
Definition
|
|
Term
| what factors CFU-GM --> basophil? |
|
Definition
|
|
Term
| what factors for CFU-GM --> neutrophil? |
|
Definition
|
|
Term
| what factors for CFU-GM --> monocyte? |
|
Definition
|
|
Term
| what factors for CFU-GM --> eosinophil? |
|
Definition
|
|
Term
| what are the 6 stages of granulocyte maturation? |
|
Definition
| myeloblast --> premyelocyte --> myelocyte --> metamyelocyte --> band --> segmented neutrophil |
|
|
Term
|
Definition
| immature nucleus, blue cytoplasm, no granules |
|
|
Term
|
Definition
| immature nucleus, blue cytoplasm, AZUROHPILIC PRIMARY GRANULES |
|
|
Term
|
Definition
| MATURING NUCLEUS, FINE SECONDARY GRANULES, cytoplasm gray-pink |
|
|
Term
|
Definition
| nucleus ECCENTRIC and INDENTED, PINK cytoplasm |
|
|
Term
|
Definition
| nucleus CRESCENT-SHAPED, pink cytoplasm |
|
|
Term
| describe segmented neutrophil aka pmn |
|
Definition
| mature nucleus (segmented), pink cytoplasm |
|
|
Term
| which forms of the WBC precursors are in the "mitotic pool"? |
|
Definition
| myeloblasts, promyelocytes, and myelocytes (capable of division) |
|
|
Term
| G-CSF vs GM-CSF, which is essential for hematopoiesis? |
|
Definition
| G-CSF is essential. GM-CSF not essential for hematopoiesis, BUT plays an important role in function of PULMONARY macrophages |
|
|
Term
| early factors in megakaryocyte production? |
|
Definition
|
|
Term
| late factors for megakaryopoiesis? |
|
Definition
| GM-CSF and thrombopoietin (act on CFU-mega) |
|
|
Term
|
Definition
|
|
Term
| what is the receptor for TPO? and what does binding to the receptor do? |
|
Definition
| c-Mpl; promotes CFU-megakaryocyte proliferation and endoreduplication of the nucleus and maturation of the nucleus |
|
|
Term
| what happens to platelet count if spleen is enlarged? removed? |
|
Definition
| spleen enlarged --> thrombocytopenia (1/3 of platelets sequestered in red pulp of spleen, if spleen enlarges, more than that will be kept inside); splenectomy --> thrombocytosis |
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