Term
| Is polycythemia considered a myeloid or lymphoid syndrome? |
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Definition
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Term
| What is another name for polycythemia vera? What is it associated with physiologically? |
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Definition
| Primary polycythemia. Neoplastic transformation of bone marrow stem cells. |
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Term
| What causes secondary polycythemia? |
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Definition
| Chronic hypoxemia w/ relative inc. in erythropoietin production. |
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Term
| What causes relative polycythemia? |
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Definition
| Dehydration which causes inc. RBC |
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Term
| Name 4 causes of hypoxia leading to secondary erythrocytosis (polycythemia). |
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Definition
| 1) Chronic lung dz 2) OSA 3) High altitude 4) High O2 affinity Hb |
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Term
| Name 2 reasons for increased erythropoietin leading to secondary polycythemia. |
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Definition
| Renal dz or erythropoietin administration |
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Term
| Distinguish polycythemia vera from secondary and relative polycythemia. |
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Definition
| 1) Absence of hypoxia and dehydration 2) Overproduction of RBC, WBC, and plts independent of erythropoietin. |
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Term
| Who does polycythemia typically affect? |
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Definition
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Term
| Name 5 c/o a pt w/ polycythemia vera may present with. |
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Definition
| 1) HA 2) Vertigo 3) Visual Disturbances 4) Pruritus 5) Claudication |
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Term
| Name 2 visual signs that may be apparent in a pt w/ polycythemia vera. |
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Definition
| Plethora (facial flushing) and erythromelalgia (red LE) |
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Term
| Name 4 medical conditions that may result from polycythemia vera. |
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Definition
| 1) TIA/CVA 2) MI 3) DVT 4) Splenomegaly |
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Term
| Why would polycythemia vera cause or exacerbate gout? |
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Definition
| Increased uric acid which is a breakdown product of RBC |
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Term
| Name 5 lab values that would be inc. in polycythemia vera. |
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Definition
| RBC, Hb/Hct, WBC, Plts, uric acid |
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Term
| Describe the expected finding in bone marrow of a pt w/ polycythemia vera. |
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Definition
| Panhyperplasia (erythroid, myeloid, megakarocytic) |
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Term
| Describe the expected finding of bone marrow in secondary erythrocytosis. |
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Definition
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Term
| What type of CA can be a complication of polycythemia vera? |
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Definition
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Term
| Describe the tx options for polycythemia vera. |
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Definition
| 1) Phlebotomy or blood-letting 2) Bone marrow suppresing agents (hydroxyurea) 3) Asprin |
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Term
| What clinical manifestation of polycythemia vera is not present in secondary polycythemia? |
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Definition
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