Term
|
Definition
|
|
Term
| Calculation for WBC estimate |
|
Definition
|
|
Term
| Calculation for platelet estimate |
|
Definition
|
|
Term
| Target cells seen in what 3 things |
|
Definition
| "liver disease, thalassemia, hemoglobinopathies" |
|
|
Term
| Basophilic stippling due to |
|
Definition
|
|
Term
| Maturation sequence of PMN |
|
Definition
| "blast, promyelocyte, myelocyte, metamyelocyte, band, PMN" |
|
|
Term
| LAP test distinguishes which 2 things |
|
Definition
| Leukemoid RXN (+) from CML (-) |
|
|
Term
| What is a reflection of total body iron stores |
|
Definition
|
|
Term
| What 2 diseases associated with cold autoimmune HA |
|
Definition
| mycoplasma pneumonia and mono |
|
|
Term
| What 2 RBC abnormalities are present in iron def anemia |
|
Definition
|
|
Term
| Alpha globin gene loci on which chromosome |
|
Definition
|
|
Term
| Tx for sideroblastic anemia |
|
Definition
| pyridoxine in large doses |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| "Chipmunk fascies, spontaneous fractures, hair on end of skull xray" |
|
Definition
|
|
Term
| Ring sideroblasts in a plumber |
|
Definition
| Lead overload blocking heme synthesis (ALA synthase) |
|
|
Term
|
Definition
| "Homocysteine--> Methionine, Methylmalonyl CoA--> succinyl CoA" |
|
|
Term
| Deficiency of B12 results in what? |
|
Definition
| Trapping of THF as 5'mTHF |
|
|
Term
| Megaloblastic anemia of infancy caused by |
|
Definition
| Deficiency of Transcobalamin II (peripheral tissues) |
|
|
Term
| What is increased in the urine of B12 deficient patients |
|
Definition
| Methylmalonic acid (homocysteine also in Folate deficit) |
|
|
Term
| What is the side effect of B12 IM injections? |
|
Definition
|
|
Term
| Chronic exposure to what causes excessive oxidation of cobalamins? |
|
Definition
|
|
Term
| Replace blood volume and O2 carrying capacity |
|
Definition
| Whole blood (has no platelets/granulocytes) |
|
|
Term
| Increase 02 carrying capacity |
|
Definition
|
|
Term
| Thrombocytopenia/thrombocytopathy |
|
Definition
|
|
Term
|
Definition
| Platelets and Granulocytes |
|
|
Term
| What must be present to give granulocyte concentrate? |
|
Definition
| "Fever, neutropenia, bacterial infection, bone marrow hypoplasia" |
|
|
Term
| Labile/Stable coagulation factor replacement |
|
Definition
|
|
Term
| Albumin/Plasma Protein Fraction |
|
Definition
|
|
Term
| Blood donation tested for |
|
Definition
| "HIV, HBS/C, Hep C, p24, HTLV, Syphillis" |
|
|
Term
| Febrile Nonhemolytic RXN and Tx |
|
Definition
| "prev immun sensitization to donor WBCs,platelets,proteins;Tx:antipyretics (aspirin/tylenol)" |
|
|
Term
| "Flushing, itching, hives post transfusion; TX" |
|
Definition
| Allergic RXN TX: antihistamines prophylactically |
|
|
Term
| Infusions of IgA proteins into patient with Abs to IgA |
|
Definition
|
|
Term
| Bilateral noncardiogenic pulmonary edema |
|
Definition
| TRALI TX with ventilatory support and steroids |
|
|
Term
| G6PD deficiency leads to the formation of |
|
Definition
| Heinz Bodies by oxidation of Hgb in RBCs |
|
|
Term
| Drugs related to acquired hemolytic anemias |
|
Definition
| "PCN, quinidine, alpha-methyldopa" |
|
|
Term
| What does parvovirus B19 target |
|
Definition
| P antigen on RBC precursors in BM |
|
|
Term
| Which G6PD type is positive for favism |
|
Definition
|
|
Term
| What tests for G6PD deficiency |
|
Definition
| Rapid flourescent screening test |
|
|
Term
| Abnormal autohemolysis test not corrected with glucose |
|
Definition
| Pyruvate Kinase deficiency |
|
|
Term
| Sickle Cell osteomyelitis caused by |
|
Definition
|
|
Term
| Characteristics of Hg C trait and disease |
|
Definition
| "Target cells, Hemoglobin C crystals" |
|
|
Term
| Which proteins' bindings are affected in PNH |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| antithrombin III inactivates |
|
Definition
|
|
Term
| 2 types of granules in platelets |
|
Definition
| Alpha granules and Dense Bodies |
|
|
Term
|
Definition
| "2,7,9,10, Protein C and S" |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| "HA, thrombocytopenia, fever, renal damage, neurological changes" |
|
|
Term
| Which bacteria associated with HUS |
|
Definition
|
|
Term
| Pathology of Factor V Leiden |
|
Definition
| Factor Va cannot be inactivated by Protein C |
|
|
Term
| Defective GPIb-IX-V platelet membrane receptor |
|
Definition
|
|
Term
| Defeciency of GPIIb-IIIA platelet receptor |
|
Definition
| Glanzmann's thrombasthenia |
|
|
Term
|
Definition
| deficiency of vWF cleaving mettaloprotease (ADAMTS13) |
|
|
Term
|
Definition
| Desmopressin (DDAVP) which induces release of vWF |
|
|
Term
| Only factor not decreased in liver disease |
|
Definition
|
|
Term
| Most common cause of inherited thrombophilia |
|
Definition
|
|
Term
| What is the mechanism of warfarin induced skin necrosis |
|
Definition
| decreased protein C levels |
|
|
Term
| Antiphospholipid antibody interferes with what? |
|
Definition
|
|
Term
| "Livedo reticularis, sneddon's syndrome" |
|
Definition
| Antiphospholipid antibody (lupus anticoagulant) |
|
|
Term
| What is released from platelets in the release RXN |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Circulating plasmin inactivated by |
|
Definition
|
|
Term
|
Definition
| "fibrin, factors 1, 5, 7" |
|
|
Term
| Thrombolytic antagonists (2) |
|
Definition
| aminocaproic and tranexamic acid |
|
|
Term
| Definitive evidence of myeloid leukemia |
|
Definition
|
|
Term
| Genetic abnormality seen in M1 AML |
|
Definition
|
|
Term
| Genetic abnormality seen in M2 AML |
|
Definition
| "t(8,21)- associated with better prognosis" |
|
|
Term
| AML with abundance of auer rods |
|
Definition
|
|
Term
| "M3 presents with, genetic abnormality and Tx" |
|
Definition
| "DIC, t(15,17) and Vit A (retinoic acid)" |
|
|
Term
|
Definition
| Chr 16 inversion- better prognosis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| abnormality of 1-3 cell lines |
|
Definition
|
|
Term
| myelodysplastic syndrome most commonly effects which cell line |
|
Definition
|
|
Term
| Type of myelodysplastic syndromes |
|
Definition
| Refractory anemia/with ringed sideroblasts/with excess blasts |
|
|
Term
| Chromosome anomaly with myelodysplastic syndromes |
|
Definition
|
|
Term
| 4 myeloproliferative disorders |
|
Definition
| "CML, PV, ET, myelofibrosis" |
|
|
Term
| Genetic abnormality w CML |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Induction therapy for AML |
|
Definition
| anthracycline + cytarabine |
|
|
Term
|
Definition
|
|
Term
| Blasts in spinal fluid only in which AML |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| allogeneic stem cell transplant |
|
|
Term
| Possible Myelodysplastic Tx |
|
Definition
| "5-azacytidine, decitabine, lenalidomide" |
|
|
Term
| "Point mutation often seen with PV, ET, MF" |
|
Definition
|
|
Term
|
Definition
| Imatinib (inhibits bcr-abl tyrosine kinase |
|
|
Term
|
Definition
| Burkitt and Hodgkin lymphoma |
|
|
Term
| What is the low grade and high grade B cell lymphoma |
|
Definition
| L: follicular; H: Burkitt |
|
|
Term
|
Definition
| Kappa or Lambda light chain but NOT both |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| "Disseminated, non-contiguous, Waldeyer and mesenteric, histo subtype important" |
|
|
Term
|
Definition
| "Peripheral blood, BM/Lymph node" |
|
|
Term
| Passes through germinal center |
|
Definition
|
|
Term
| "Lymphocytosis, CD5+, and ?" |
|
Definition
| Smudge cell=CLL (B Cells) |
|
|
Term
|
Definition
| Richter's syndrome (Large B cell lymphoma) |
|
|
Term
| "Lack of tingible body macrophages, CD10+, lymphadenopathy" |
|
Definition
|
|
Term
|
Definition
| H Pylori infection of stomach |
|
|
Term
| Rapidly enlarging symptomatic mass |
|
Definition
| diffuse large B cell lymphoma |
|
|
Term
|
Definition
| "Mantle Cell Lymphoma (aggressive, chemo resistant)" |
|
|
Term
| Mantle Cell Lymphoma genetics |
|
Definition
|
|
Term
|
Definition
| "Starry sky, tingible body macrophages, CD10+, 20+, sIg+" |
|
|
Term
| Peripheral T cell immuno markers |
|
Definition
|
|
Term
| Mycosis Fungoides immuno markers |
|
Definition
|
|
Term
| Adult T cell lymphoma/leukemia associated w/ |
|
Definition
|
|
Term
| Thrombocytopenia in children w/ bone pain |
|
Definition
|
|
Term
| favorable genetics in ALL |
|
Definition
| "hyperdiploidy, Philly unfavorable" |
|
|
Term
|
Definition
| "CD 10+,19+,20+,34+, TdT+" |
|
|
Term
|
Definition
|
|
Term
| Mediastinal Mass and cervical lymphadenopathy |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Reed Sternberg immuno markers |
|
Definition
| "CD 10-,20-15+,30+, LCA-" |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| Nodular Lymphocyte Predominant HL |
|
|
Term
| Nodular Lymphocyte Predominant HL immuno markers |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Waldenstrom Macrglobulinemia |
|
Definition
| "IgM secretion, incurable" |
|
|
Term
| What is commonly mutated in MTC |
|
Definition
|
|
Term
|
Definition
|
|
Term
| CF PCR Probe only matches w/ |
|
Definition
|
|
Term
| Increase risk of thrombosis w/ Factor 5 Leiden |
|
Definition
|
|
Term
| PET scans with lymphoma for |
|
Definition
| following response to therapy |
|
|
Term
| Diffuse Large B Cell Lymphoma Tx |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Cloverleaf/Flower Like lymphocytes |
|
Definition
| Adult T cell Lymphoma/leukemia |
|
|
Term
| Adult T cell lymphoma/leukemia Tx |
|
Definition
| allogeneic stem cell transplant |
|
|
Term
|
Definition
| "MM (hypercalcemia, renal failure, anemia, bone lesions)" |
|
|
Term
|
Definition
| "Corticosteroids (decadrine), thalidomide" |
|
|
Term
|
Definition
| "plasmaphersis, chemo and rituximab" |
|
|
Term
| B cell with hypogammaglobulinemia |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| "lympocytosis,+enlarged nodes,+enlarged spleen/liver,+anemia,+thrombocytopenia" |
|
|
Term
|
Definition
| "cyclophosphamide, fludarabine, rituximab" |
|
|
Term
| ALL bad prognostic indicator and Tx |
|
Definition
| "Philly Chr, allogeneic stem cell transplant" |
|
|
Term
| Chemotherapy that causes blood in urine |
|
Definition
| "cyclophosphamide, ifosfamide" |
|
|
Term
| Chemotherapy that causes pumonary infiltrates and fibrosis |
|
Definition
|
|
Term
| Chemo that causes ringing in the ears |
|
Definition
|
|
Term
|
Definition
| Thymidylate synthase and methylene tetrahydrofolate |
|
|
Term
| Chemo that causes hand-foot syndrome |
|
Definition
|
|
Term
| 6-mercaptopurine accumulates with this mutation |
|
Definition
|
|
Term
| Chemo with red urine (not blood) |
|
Definition
|
|
Term
| Two chemo drugs with cardiac toxicity |
|
Definition
| Doxorubicin and Epirubicin |
|
|
Term
| Chemo with low BM toxicity |
|
Definition
| Bleomycin (but high pulmonary toxicity) and Vincristine |
|
|
Term
| Chemo with foot drop and motor dysfunction |
|
Definition
|
|
Term
| Chemo with weakening of heart muscle |
|
Definition
|
|
Term
| Normal PT and abnormal PTT |
|
Definition
| "Defect in factor 8,9,10,11, heparin therapy" |
|
|
Term
| Elevation of PT w/ normal PTT |
|
Definition
| "Vit K deficiency, Warfarin Therapy, Liver disease" |
|
|
Term
|
Definition
|
|
Term
| Identical twin stem cell transplant |
|
Definition
|
|
Term
| Improves engraftment in patient with aplastic anemia |
|
Definition
|
|
