Term
| Infectious causes of lymphadenitis w/ granulomata |
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Definition
| "Like (lyc) TB." Lymphogranuloma venereum, Yersinia, Cat scratch, Tularemia, Brucellosis. And of course, TB. |
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Term
| Normal kappa to lambda ratio |
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Definition
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Term
| Follicles in follicular hyperplasia |
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Definition
| All shapes and sizes. "Polarized" mitosis. Sharp borders. |
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Term
| Follicles in follicular lymphoma |
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Definition
| Every follicle looks the same. Mitosis equal throughout (non-polarized). Vague borders. |
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Term
| Follicular hyperplasia: what is "polarization"? |
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Definition
| More mitosis on one side of follicle than the other |
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Term
| Leukemia: acute vs. chronic? |
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Definition
| Acute = blasts. Chronic = mature cells |
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Term
| Pattern of spread: Hodgin's vs. non-Hodgkin's? |
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Definition
| Hodgkin's: lymph nodes spread contiguously. Non-Hodgkin's: spread any which way. |
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Term
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Definition
| Hodgkin's lymphoma (RS cells) |
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Term
| CD19+, CD20+, kappa/lambda high. |
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Definition
| Non-Hodgkin's lymphoma, B-cell |
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Term
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Definition
| Non-Hodgkin's lymphoma, T-cell |
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Term
| Ann Arbor: stage I and II? |
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Definition
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Term
| Ann Arbor staging is used for what? |
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Definition
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Term
| Ann Arbor stage: Stage III? |
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Definition
| Both sides of diaphragm, no critical organs |
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Term
| Ann Arbor stage: Stage IV? |
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Definition
| Both sides of diaphragm, involvement of critical organ (i.e. bone marrow) |
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Term
| Cancer: grading vs. staging |
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Definition
| Grade = level of AGGRESSION. Stage = SPREAD to other parts of body ("The whole body is a 'stage' for cancer.") |
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Term
| Hodgkin's lymphoma: lots of RS cells or a few? |
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Definition
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Term
| What do RS cells look like? |
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Definition
| Owl eyes. Eyes = enormous nucleoli w/ perinucleolar clearing |
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Term
| Average age to get Hodgkin's lymphoma |
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Definition
| 32 y.o. One of the most common malignancies in young adults. |
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Term
| A diagnosis of ALL requires what % of blasts in marrow? |
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Definition
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Term
| Most Non-Hodgkin's lymphoma come from which type: B-cells, T-cells, or NK cells? |
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Definition
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Term
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Definition
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Term
| TdT-, CD34-, CD19+, CD45+, sIg+, cyIg- |
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Definition
| CLL (aka B-cell lymphoma/leukemia) |
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Term
| TdT-, CD34-, CD19-, CD45-, sIg-, cyIg+ |
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Definition
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Term
| Grading B-cell lymphoma: small lymphocytes |
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Definition
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Term
| Grading B-cell lymphoma: large lymphocytes |
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Definition
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Term
| Grading B-cell lymphoma: Burkitt's |
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Definition
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Term
| Grading B-cell lymphoma: ALL |
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Definition
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Term
| Are low grade lymphomas easy or hard to cure? |
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Definition
| Hard (paradox)! Low grade but high stage |
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Term
| Are high grade lymphomas easy or hard to cure? |
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Definition
| Easier (paradox)! Low or high stage |
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Term
| Important small B-cell lymphomas/leukemias |
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Definition
| CLL, Mantle Cell lymphoma, Hairy Cell leukemia, Follicular lymphoma |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
| CD5+, Cyclin D1 defective |
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Definition
| Mantle cell lymphoma (note that CD5 is normally a T cell antigen) |
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Term
| "Cleave cells" (looks like a cell-sized diplococcus) |
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Definition
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Term
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Definition
| Follicular lymphoma or Burkitt lymphoma |
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Term
| What is the most common non-Hodgkin lymphoma in the USA? |
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Definition
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Term
| Lymph nodes w/ completely obliterated architecture. Mixed bag of large, neoplastic cells w/ small, mature cells. |
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Definition
| Diffuse large B-cell lymphoma |
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Term
| This lymphoma has ↑↑ incidence among immunosuppressed pts (ex. HIV+) |
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Definition
| Diffuse large B cell lymphoma |
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Term
|
Definition
| Burkitt lymphoma ("the B looks like an 8") |
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Term
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Definition
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Term
| Burkitt lymphoma affects what age group? |
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Definition
| Children and young adults |
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Term
| Burkitt lymphoma affects what age group? |
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Definition
| Children and young adults |
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Term
| EBV+ is associated with what MALIGNANCY? |
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Definition
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Term
| TdT-, CD34-, CD3+, CD5+, CD30+/- |
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Definition
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Term
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Definition
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Term
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Definition
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Term
| Azurophilic granulation of blasts |
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Definition
| AML (azure granules = myeloperoxidase -> monocytes) |
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Term
| Dohle bodies (slightly bigger pinpoint, purple granules) |
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Definition
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Term
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Definition
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