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Hematology/Oncology
Cancer Drugs
57
Chemistry
Graduate
08/12/2019

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Cards

Term
Mostellar Formula
(BSA)
Definition
BSA (m^2)=(Height(cm) X Wt(kg)/3600)^1/2
Term
Carboplatin Dosing
FDA recommends
Definition
capping the dose for desired exposure (AUC) to avoid potential toxicity due to overdosing
Term
Calvert formula
[Max Carbop;latin Dosing]
Definition
Total Carboplatin Dose (mg) = (target AUC) x (GFR +25)
[Calvert formula]
Term
Anthracycline Drug Names
(All red except mitoxantrone is blue)
Definition
Doxorubicin (Adriamycin)
Daunorubicin (Cerubidine)
Epirubicin (Ellence)
Mitoxantrone (Novantrone)
Term
Anthracycline MOA
Definition
Diffuse across cell membranes to cell nucleus
-intercalate DNA dbl helix
-free radical generation
-interefere w/ topoisomerase II
Term
Anthracyclines Acute tox
Definition
Neutropenia/anemia
GI: Mod-severe NV (bolus)
D, mucositis(cont infusion)
Alopecia, skin hyperpig/damage
Term
Anthracycline Cardiotoxicity
(HAS MAX LIFETIME DOSES cus this)
Definition
Acute: Prolong QT, ST and T changes, arrythmias,peri/myocarditis, CHF
Term
Taxane Drugs
Definition
Paclitaxel (Taxol)
nab-Paclitaxel (Abraxane)--uses nanoparticles to deliver med
Docetaxel (Taxotere)
Cabazitaxel (Jevtana)
Term
TAXANE BBW
Definition
Anaphylaxis and sever Hypersensitv rxns(Fatal)
Term
PAclitaxel Premed
Definition
Diphen hydramine, cimetidine/Ranitidine/or famotidine,dexamethasone
(use filter)
Term
Docetaxol premed
Definition
Dex 8 mg po bid Dex x 3 days begin 24 hrs prior
Term
PAclitaxel with platinum...do what???
Definition
Administer before platinum (Filter)
Term
Paclitaxel infused how
Definition
24,3, or 1 hr weekly infusions
Term
Docetaxel and Cabazitaxel infused how long
Definition
1 hr infusions
Term
TAXANE Toxicities
Definition
HAND-FOOT syndrome (bad)
-Skin/nail changes
Peripheral Neuropathy
Myeloseuppression
Term
TAXANE ALOPECIA
Definition
Full body alopecia

---Ocular toxicity
Term
TAXANE Dose adj?
Definition
Hepatic Dose adjust
Term
Platinum Drugs
Definition
Cisplatin ()
Carboplatin ()
Oxaliplatin ()
Term
Platinum MOA
Definition
create cross links in DNA that require excision and repair. causes apoptosis of cell sometimes
Term
Cisplatin Toxicities
Definition
NV (HIGH)
Nephrotoxic
Peripheral neuropathy
Ototoxic
Term
Cisplatin electrolyte change?
Definition
Hypomagnesemia and hypokalemia
Term
Oxaliplatin
Definition
Neurotoxic
Reversible peripheral neuropathy--- laryngeal dysesthesia {Precipitated or exacerbated by exposure to cold temperature
or cold objects}
Term
Oxaliplatin Peripheral neuropathy usually
Definition
REVERSIBLE
Term
Nephrotoxic and ototoxic Platinums
Definition
Carbo and Cis
Term
Gemcitabine (Gemzar) MOA
Definition
[S phase of cell cycle] Competes with dCTP for incorporation into DNA and allows
incorporation of gem nucleotide into DNA
Term
Gemcitabine (Gemzar)Toxicity
Definition
Myelosuppression (Big dose limiting)
LFT elevations
NV,flu sxs
Peripheral edema
Term
Gemcitabine dose
Definition
1000-1200mg/m^2/dose weekly
Term
Gemcitabine (Gemzar) Premedicate
Definition
Dex 20 mg po (due to rash incidence)
Term
Cytarabine (Cytosar-U) Dose
Definition
dose 100-200mg/m^2 cont IV for 7 days
Term
Cytarabine Dose Adj
Definition
Recommended for Ren and Hep
Term
Cytarabine (Cytosar-U) Toxicity
Definition
Myelosuppression
NV (HIGH)
Mucositis
Rash, hand foot, alopecia
Term
Cytarabine (Cytosar-U) MOA
Definition
(S-Phase)
Incorporates into DNA (Chain termination)
Inhibits DNA polymerase
Crosses Blood brain barrier
Term
Methotrexate MOA
Definition
Inhibits dihydrofolate reducase, cell cycle specific (S phase), radiosensitizer
Term
Methotrexate Dose
Definition
– 3 g/m^2 for ALL to 12 g/m^2 for sarcoma
Term
Methotrexate Toxicity
Definition
Nephrotoxicity
mucositis (diminished with Leucovorin)
NV
Myelosuppression
Term
Which Methotrexate for high dose and intrathecal
Definition
preservative free
Term
High dose Methotrexate is....
Definition
Doses >1000 mg/m^2
-resistance overcome at higher doses,
-increased exposure to cytotoxic concentrations
Term
Prevent High Dose MTX Toxicity by
Definition
-hydrate during tx and before if pt dehydrated
-drain all 3rd spaced fluids
-Leucovorin rexcue
-keep urine >7
-UOP >100mL/hour
Term
Leucovorin
Definition
-High dose MTX (>/=1 g/m 2 ) requires drug level monitoring and leucovorin rescue
-active form of folic acid
-replaces reduced folates
-rescues cells from cytotoxic effects of MTX
Term
Alkylating Agent Drugs
Definition
Cyclophosphamide, Ifosfamide, Busulfan, Carmustine
Chlorambucil, Dacarbazine, Lomustine, Mechlorethamine, Melphalan, Procarbazine, Streptozosin, Temozolomide, Thiotepa
Term
Alkylating Agent Toxicity
Definition
Alopecia, myellosuppression
NV
Infertility
Term
Cyclophosphomide PO Early in the day admin why
Definition
avoids cystitis
Term
Ifosfamide PO causes
Definition
Excess CNS toxicity
Term
Cyclophosphomide Toxicity
Definition
Myellosupp, infusion reaction (very rare)
NV
Sterilit, SIADH, Hemorrhagic cystitis
Term
Ifosfamide Toxicity
Definition
Fanconi like syndrome(ren damage), CNS toxicity
Myellosupp
NV
Sterilit, SIADH, Hemorrhagic cystitis
Term
Bendamustine MOA
Definition
Exact MOA unknown, forms covalent bonds resulting in DNA crosslinks, active against both quiescent and dividing cells
Term
Bendamustine Dose
Definition
– 70-120mg/m2 days 1-2
Term
Bendamustine interacts w/ cipro smoking omeprazole why?
Definition
Active metabolite formed by CYP1A2
Term
Vinca Alkaloids
Definition
Vincristine (Oncovin)
Vinblastine (Velban)
Vinorelbine (Navelbine)
Term
Vinca Alkaloids Adj
Definition
Hepatic adjustments

[No renal adj]
Term
Vinorelbine (Navelbine) Adj
Definition
TBili 2.0-3.0: 50% dose • TBili > 3.0: 25% dose
Term
Vincristine (Oncovin)Adj
Definition
TBili 1.5-3.0: 50% dose
• TBili > 3.0: 25% dose
Term
Vinca Alkaloids Toxicity
Definition
-Neurotoxicity (Dose limitng)
-Vincristine>Vinblastine>Vinorelbine
-periph neur
-Neutropenia
-Alopecia,rash
Term
Vinca Alkaloids needs (vesicant)
Definition
Hyaluronidase, Heat, Central line
Term
Vinca Alkaloids Intrathecal?
Definition
NNOOOOOO!
Black Box Warning says its LETHAL
Term
Camptothecins
Definition
Topotecan
Irinotecan (Camptosar)

[ (S phase)Topoisomerase I inhibitors ultimately leads to double- strand DNA breaks (irreversible)]
Term
Topotecan SFX
Definition
Myelosuppression
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