Term
|
Definition
| BSA (m^2)=(Height(cm) X Wt(kg)/3600)^1/2 |
|
|
Term
Carboplatin Dosing
FDA recommends |
|
Definition
| capping the dose for desired exposure (AUC) to avoid potential toxicity due to overdosing |
|
|
Term
Calvert formula
[Max Carbop;latin Dosing] |
|
Definition
Total Carboplatin Dose (mg) = (target AUC) x (GFR +25)
[Calvert formula] |
|
|
Term
Anthracycline Drug Names
(All red except mitoxantrone is blue) |
|
Definition
Doxorubicin (Adriamycin)
Daunorubicin (Cerubidine)
Epirubicin (Ellence)
Mitoxantrone (Novantrone) |
|
|
Term
|
Definition
Diffuse across cell membranes to cell nucleus
-intercalate DNA dbl helix
-free radical generation
-interefere w/ topoisomerase II |
|
|
Term
|
Definition
Neutropenia/anemia
GI: Mod-severe NV (bolus)
D, mucositis(cont infusion)
Alopecia, skin hyperpig/damage |
|
|
Term
Anthracycline Cardiotoxicity
(HAS MAX LIFETIME DOSES cus this) |
|
Definition
| Acute: Prolong QT, ST and T changes, arrythmias,peri/myocarditis, CHF |
|
|
Term
|
Definition
Paclitaxel (Taxol)
nab-Paclitaxel (Abraxane)--uses nanoparticles to deliver med
Docetaxel (Taxotere)
Cabazitaxel (Jevtana) |
|
|
Term
|
Definition
| Anaphylaxis and sever Hypersensitv rxns(Fatal) |
|
|
Term
|
Definition
Diphen hydramine, cimetidine/Ranitidine/or famotidine,dexamethasone
(use filter) |
|
|
Term
|
Definition
| Dex 8 mg po bid Dex x 3 days begin 24 hrs prior |
|
|
Term
| PAclitaxel with platinum...do what??? |
|
Definition
| Administer before platinum (Filter) |
|
|
Term
|
Definition
| 24,3, or 1 hr weekly infusions |
|
|
Term
| Docetaxel and Cabazitaxel infused how long |
|
Definition
|
|
Term
|
Definition
HAND-FOOT syndrome (bad)
-Skin/nail changes
Peripheral Neuropathy
Myeloseuppression |
|
|
Term
|
Definition
Full body alopecia
---Ocular toxicity |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Cisplatin (Platinol) Carboplatin (Paraplatin) Oxaliplatin (Eloxatin) |
|
|
Term
|
Definition
| create cross links in DNA that require excision and repair. causes apoptosis of cell sometimes |
|
|
Term
|
Definition
| NV (HIGH)[acute&delayed] Nephrotoxic Peripheral neuropathy Ototoxic |
|
|
Term
| Cisplatin electrolyte change? |
|
Definition
| Hypomagnesemia and hypokalemia |
|
|
Term
|
Definition
Neurotoxic
Reversible peripheral neuropathy--- laryngeal dysesthesia {Precipitated or exacerbated by exposure to cold temperature
or cold objects} |
|
|
Term
| Oxaliplatin Peripheral neuropathy usually |
|
Definition
|
|
Term
| Nephrotoxic and ototoxic Platinums |
|
Definition
|
|
Term
|
Definition
[S phase of cell cycle] Competes with dCTP for incorporation into DNA and allows
incorporation of gem nucleotide into DNA |
|
|
Term
| Gemcitabine (Gemzar)Toxicity |
|
Definition
Myelosuppression (Big dose limiting)
LFT elevations
NV,flu sxs
Peripheral edema |
|
|
Term
|
Definition
| 1000-1200mg/m^2/dose weekly |
|
|
Term
| Gemcitabine (Gemzar) Premedicate |
|
Definition
| Dex 20 mg po (due to rash incidence) |
|
|
Term
| Cytarabine (Cytosar-U) Dose |
|
Definition
| dose 100-200mg/m^2 cont IV for 7 days |
|
|
Term
|
Definition
| Recommended for Ren and Hep |
|
|
Term
| Cytarabine (Cytosar-U) Toxicity |
|
Definition
Myelosuppression
NV (HIGH)
Mucositis
Rash, hand foot, alopecia |
|
|
Term
| Cytarabine (Cytosar-U) MOA |
|
Definition
(S-Phase)
Incorporates into DNA (Chain termination)
Inhibits DNA polymerase
Crosses Blood brain barrier |
|
|
Term
|
Definition
| Inhibits dihydrofolate reducase, cell cycle specific (S phase), radiosensitizer |
|
|
Term
|
Definition
| – 3 g/m^2 for ALL to 12 g/m^2 for sarcoma |
|
|
Term
|
Definition
Nephrotoxicity
mucositis (diminished with Leucovorin)
NV
Myelosuppression |
|
|
Term
| Which Methotrexate for high dose and intrathecal |
|
Definition
|
|
Term
| High dose Methotrexate is.... |
|
Definition
Doses >1000 mg/m^2
-resistance overcome at higher doses,
-increased exposure to cytotoxic concentrations |
|
|
Term
| Prevent High Dose MTX Toxicity by |
|
Definition
-hydrate during tx and before if pt dehydrated
-drain all 3rd spaced fluids
-Leucovorin rexcue
-keep urine >7
-UOP >100mL/hour |
|
|
Term
|
Definition
-High dose MTX (>/=1 g/m 2 ) requires drug level monitoring and leucovorin rescue
-active form of folic acid
-replaces reduced folates
-rescues cells from cytotoxic effects of MTX |
|
|
Term
|
Definition
Cyclophosphamide, Ifosfamide, Busulfan, Carmustine
Chlorambucil, Dacarbazine, Lomustine, Mechlorethamine, Melphalan, Procarbazine, Streptozosin, Temozolomide, Thiotepa |
|
|
Term
| Alkylating Agent Toxicity |
|
Definition
Alopecia, myellosuppression
NV
Infertility |
|
|
Term
| Cyclophosphomide PO Early in the day admin why |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Cyclophosphomide Toxicity |
|
Definition
Myellosupp, infusion reaction (very rare)
NV
Sterilit, SIADH, Hemorrhagic cystitis |
|
|
Term
|
Definition
Fanconi like syndrome(ren damage), CNS toxicity
Myellosupp
NV
Sterilit, SIADH, Hemorrhagic cystitis |
|
|
Term
|
Definition
| Exact MOA unknown, forms covalent bonds resulting in DNA crosslinks, active against both quiescent and dividing cells |
|
|
Term
|
Definition
|
|
Term
| Bendamustine interacts w/ cipro smoking omeprazole why? |
|
Definition
| Active metabolite formed by CYP1A2 |
|
|
Term
|
Definition
Vincristine (Oncovin)
Vinblastine (Velban)
Vinorelbine (Navelbine) |
|
|
Term
|
Definition
Hepatic adjustments
[No renal adj] |
|
|
Term
| Vinorelbine (Navelbine) Adj |
|
Definition
| TBili 2.0-3.0: 50% dose • TBili > 3.0: 25% dose |
|
|
Term
|
Definition
TBili 1.5-3.0: 50% dose
• TBili > 3.0: 25% dose |
|
|
Term
|
Definition
-Neurotoxicity (Dose limitng)
-Vincristine>Vinblastine>Vinorelbine
-periph neur
-Neutropenia, (myelosuppression)
-Alopecia,rash |
|
|
Term
| Vinca Alkaloids needs (vesicant) |
|
Definition
| Hyaluronidase (extravasation), Heat(extravasation), Central line (to prevent extravasation) |
|
|
Term
| Vinca Alkaloids Intrathecal? |
|
Definition
NNOOOOOO!
Black Box Warning says its LETHAL |
|
|
Term
|
Definition
| Topotecan (Hyacamtin) Irinotecan (Camptosar) Cell cycle specific (S phase) [ (S phase)Topoisomerase I inhibitors ultimately leads to double- strand DNA breaks (irreversible)] |
|
|
Term
|
Definition
Myelosuppression
Mucositis
Full body Alopecia
(PO has DIARRHEA) |
|
|
Term
|
Definition
Enzyme family required for DNA synthesis
-cleave and reseal backbone of DNA |
|
|
Term
| Irinotecan (Camptosar) metabolism |
|
Definition
SN-38 =active metabolite
UGT1A1 (polymorphisms = dec metab) |
|
|
Term
| Topotecan (Hycamtin) is a ...parent drug |
|
Definition
|
|
Term
|
Definition
DIARRHEA!!!!
NV
Alopecia
Myelosupp
Fatigue
Rash |
|
|
Term
| IRINOTECAN (Camptosar) DIRRHEA may be///// |
|
Definition
Acute (<24 hrs)
OR
Delayed (>24 hrs) |
|
|
Term
Treat acute IRINOTECAN DIARRHEA??
CHRONIC?? |
|
Definition
Acute: Atropine
OR
Delayed Loperamide |
|
|
Term
| Caution in this allele for neutropenia/toxic death IRINOTECAN |
|
Definition
UGT1A1*28
-Reduce initial dose |
|
|
Term
Epipodophyllotoxins
Target what phase of cell cycle |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Myelosupp (dose limiting) (Neutropenia>Thrombo)
GI toxic (NV w/ PO)
Taste changes
Alopecia, Hypersentivty rxns |
|
|
Term
| Bleomycin (Blenoxane) used for |
|
Definition
| Testicular cancers and lymphomas |
|
|
Term
|
Definition
Fever chills,flulike
Alopecia
Hypersensitivity RXNS
Mucositis, PULMONARY
RAYNAUDS SYNDROME (cold extremities) |
|
|
Term
|
Definition
Phenytoin:dec phenytoin conc
Cisplatin: dec clearance of bleomycin
Etoposide: inc cytotoxic activity |
|
|
Term
|
Definition
[Antimetabolite]
Inhibits enzymes (DNA polymerase, DNA
primase, ribonucleotide reductase)
-inhibs DNA synth |
|
|
Term
|
Definition
(S phase)[antimetabolite]
incorporation into DNA and allows incorporation
of gem nucleotide into DNA |
|
|
Term
|
Definition
Myelosuppression
Immunosuppression (dec CD4+)
Neurotoxic(HA,somnolence,periph neur) |
|
|
Term
| Fluorouracil Toxicity (5FU) |
|
Definition
| Alopecia, Nail Changes, NV, Myelosupp, Skin rash, Cardiac TOXIC, MUCOSITIS Diarrhea |
|
|
Term
| Capecitabine (Xeloda) is a prodrug of.... |
|
Definition
|
|
Term
| Capecitabine (Xeloda) interacts with.....(BBW) |
|
Definition
| Metab by CYP 2C9 BBW: Warfarin. Monitor INR Phenytoin |
|
|
Term
| Capecitabine (Xeloda) toxicity |
|
Definition
| HAND-FOOT SYNDROME!!!! MUCOSITIS Neutropenia thrombocyt |
|
|
Term
| Pemetrexed (Alimta) toxicity (analog of folic acid) |
|
Definition
| <40ml/min not reccomended Myelosupp,Skin rash/pain/itch,edema Need: Folic acid and B12 to prevent cytopenias |
|
|
Term
|
Definition
Myelosuppress
B12 deficiency
Rash
MUCOSITIS
LOW NV
LFT elevations |
|
|
Term
|
Definition
Bortezomib
Carfilzomib
-*-Blockade of degradation pathways result in
accumulation of unwanted proteins and cell
death |
|
|
Term
| Bortezomib (Velcade) Toxicity |
|
Definition
| Thrombocyt/Neutropenia peripheral Neuropathy Hypotension CHF, ARDS Diarrhea/constipation |
|
|
Term
| Carfilzomib (Kyprolis) Toxicity |
|
Definition
Neutropenia (need acyclovir prophylactically)
Fatigue,anemia
HF, Pulmonary HTN
HEPATIC failure |
|
|
Term
| Kyprolis requires what prophylactically |
|
Definition
|
|
Term
|
Definition
Anthracyclines
Taxanes
Vinca Alkaloids
Etoposide |
|
|
Term
|
Definition
|
|
Term
|
Definition
-momab= mouse derived
-ximab= human-mouse chimer
-zumab= humanized
-mumab= fully human |
|
|
Term
| Bevacizumab (Avastin) MOA |
|
Definition
Binds to VEGF, inhibits
angiogenesis
– Humanized monoclonal antibody |
|
|
Term
| Bevacizumab (Avastin) Toxicities |
|
Definition
HTN
Proteinuria
Delayed wound healing
GI perfortion |
|
|
Term
|
Definition
| Hold for 4 weeks before and after invasive procedures |
|
|
Term
|
Definition
Chimeric monoclonal antibody targeting
CD20 antigen found on surface of normal
and malignant B lymphocytes
– Recruits immune effector functions to
mediate B-cell lysis |
|
|
Term
| Rituximab (Rituxan) Toxicities |
|
Definition
BBW: infusion related deaths (start slow)
fever, SJS, HEP B reactivation
rigors
chillshypotension |
|
|
Term
| Rituximab (Rituxan) Premed |
|
Definition
|
|
