Term
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Definition
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Term
| Follicular lymphoma genetics |
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Definition
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Term
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Definition
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Term
| Burkitt lymphoma genetics |
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Definition
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Term
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Definition
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Term
| Mantle cell lymphoma genetics |
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Definition
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Term
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Definition
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Term
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Definition
Mantle cell lymphoma
CyclinD1 |
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Term
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Definition
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Term
| Role of primary/central lymphoid tissue |
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Definition
Help grow B/T precursors to naïve state
B: BM, T: thymus |
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Term
| Role of secondary/peripheral lymphoid tissue |
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Definition
Allow Ag-cell interaction
LN, spleen, MALT |
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Term
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Definition
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Term
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Definition
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Term
| Ag-independent phase: location, result, morphology |
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Definition
Primary/central lymphoid tissue
Mature but naïve
Small cells w/ dense chromatin |
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Term
| Ag-dependent phase: location, cellular transformation |
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Definition
Secondary/peripheral lymphoid tissue
Cell inc. cyto, disperses chromatin, gains nucleolus
Form germinal centers = centroblasts/non-cleaved, lose BCL2
Mutate Ig variable region = centrocyte
Good fit = BCL2 comes back, b/c memory/plasma cells
Bad fit = apoptosis |
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Term
| Causes of lymphocytopenia |
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Definition
Congenital immunodeficiency
HIV
Cytotoxic drugs like chemo |
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Term
| Reactive causes of lymphocytosis |
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Definition
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Term
| Neoplastic causes of lymphocytosis |
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Definition
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Term
| Characteristics that differentiate neoplastic lymphocytosis from reactive (3) |
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Definition
Sustained
WBC >30,000
Clonal |
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Term
| Mono: pathogenesis, symptoms |
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Definition
| EBV in saliva infects oropharynx B cells, disseminates to lymphoid tissue |
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Term
| Mechanisms that control mono |
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Definition
CD8 T cells, NK cells
EBV-specific and non-specific Ab |
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Term
| Mono morphology: peripheral, lymph node |
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Definition
Reactive/atypical lymphocytes
Paracortical hyperplasia |
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Term
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Definition
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Term
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Definition
Middle-aged to older
Usually asymptomatic
Anemia, weight loss
Lymphadenopathy
Hepatosplenomegaly
Hypogammaglobulinemia |
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Term
| CLL morphology: peripheral, BM, LN |
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Definition
Homogenous small mature cells w/ condensed chromatin, smudge cells
BM: diffuse infiltrate
LN: diffuse infiltrate |
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Term
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Definition
19, 20
5+
23+
Dim surface Ig |
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Term
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Definition
Trisomy 12
Del. 13, 11, 17 |
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Term
| CLL is different from SLL b/c… |
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Definition
CLL mainly works in BM and blood
SLL mainly works in LN |
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Term
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Definition
Indolent but incurable
Prone to infections
Prolymphocytic transformation
Large cell transformation |
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Term
| HCL: age range, sex, symptoms (usually symptomatic) |
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Definition
Older men
Fatigue
Recurrent infection
Splenomegaly, abdominal discomfort |
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Term
| HCL morphology: peripheral, BM, spleen |
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Definition
Pancytopenia, hairy cells
BM: fried egg infiltration + fibrosis (dry tap)
Spleen: red pulp infiltration forming blood lakes |
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Term
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Definition
TRAP+
11+
25+
103+
Strong surface Ig |
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Term
| Acute bacterial and viral infections show ___ hyperplasia |
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Definition
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Term
| Causes of chronic follicular hyperplasia (3) |
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Definition
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Term
| Causes of paracortical hyperplasia (3) |
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Definition
Mono
Drug sensitivity reactions
SLE |
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Term
| Plasma cell neoplasm Ig secretion is abnormal because… (2) |
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Definition
Usually light chain produced in excess
Monoclonal |
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Term
| Monoclonal Ig: characteristics and consequences |
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Definition
Abnormal chem: deposits in tissues
Hyperviscous: blurry vision, headache, dizziness, deafness
Cryoglobulinemia: ppt at colder temps
Interfere w/ fibrin polymerization: bleeeding |
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Term
| Information obtained from SPEP or UPEP |
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Definition
Monoclonal M spike, usually in gamma region
Other Ig are reduced |
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Term
| Information obtained from IFE |
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Definition
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Term
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Definition
Free light chains in urine
Toxic to renal cells |
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Term
| Multiple myeloma: age range, sex, race, symptoms |
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Definition
Older black males
Calcium inc.
Renal insuffiency
Anemia
Bone lesions |
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Term
| Multiple myeloma: pathogenesis, prognosis |
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Definition
Infiltrate bone, plasma cell cytokines cause resorption
Light chains deposit in kidneys
Fxl hypogammaglobulinemia leads to infections (CMI is fine)
Poor, chemo extends it to 3 yrs |
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Term
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Definition
Hypercalcemia
Inc. BUN, creatinine
Inc. serum protein, proteinuria
M spike >3 g/dL |
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Term
| Multiple myeloma: protein composition |
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Definition
IgG (hyperviscous)
Free light chain
Amyloid |
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Term
| Multiple myeloma: peripheral, BM |
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Definition
Anemia, rouleaux
BM: >30% infiltration w/ abnormal plasma cells w/ fine chromatin and possibly nucleoli |
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Term
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Definition
No CRAB, no lytic lesions
M spike <3 g/dL
BM: <10% plasma cell infiltration |
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Term
| MGUS: age range, clinical course, tx |
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Definition
Older
25% have stable levels of monoclone
25% have rising levels, but it's not neoplastic
25% develop overt neoplasm
25% die of other causes
Tx: none required |
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Term
| Plasmacytoma: symptoms, BM |
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Definition
No CRAB, single lesion
BM: single mass of neoplastic cells |
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Term
| Plasmacytoma, solitary: location, progression |
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Definition
Intramedullary mass
55% progress to multiple myeloma |
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Term
| Plasmacytoma, extraosseous: location, progression |
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Definition
Oronasopharynx, sinuses
15% progress to multiple myeloma |
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Term
| Are lymphoplasmacytic lymphomas and Waldenstrom's macroglobulinemias true neoplasms? What are they? Where are they? |
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Definition
No! They're lymphomas w/ plasma cell differentiation
BM sometimes LN, spleen |
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Term
| Waldenstrom macroglobulinemia is ___ + ___ + ___ |
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Definition
Lymphoplasmacytic lymphoma
IgM monoclone
Hyperviscocity syndrome |
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Term
| Waldenstrom macroglobulinemia: symptoms |
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Definition
Visual impairment, headache, dizziness, deafness
Cryoglobulinemia
Lymphadenopathy
Hepatosplenomegaly
Anemia, bleeding
No lytic lesions |
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Term
| Waldenstrom macroglobulinemia morphology: LN |
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Definition
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Term
| Waldenstrom macroglobulinemia: prognosis, tx |
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Definition
4 years
Plasmapheresis alleviates symptoms |
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Term
| Amyloid: composition, gross and histo appearance, stain |
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Definition
Amyloid light chain (or AA) protein
Gross: waxy, white appearance
Histo: hyaline looking
Congo red: green birefringence |
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Term
| Primary systemic amyloidosis: cause |
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Definition
| Underlying plasma cell neoplasm secreting AL |
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Term
| Secondary systemic amyloidosis: cause |
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Definition
| Underlying inflammatory condition, AA protein not AL |
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Term
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Definition
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