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Hematology Internship Section 3
Coagulation Study Questions Part 1
26
Biology
Undergraduate 4
10/13/2015
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Term
Match the groups of coagulation factors to the correct description:

Consumed in Clot
 Definition
I, II, V, VIII, & XIII
Term
Match the groups of coagulation factors to the correct description:

Vitamin K Dependent
 Definition
II, VII, IX, X
Term
Match the groups of coagulation factors to the correct description:

Labile
 Definition
V, VIII
Term
Match the groups of coagulation factors to the correct description:

Not found in serum
 Definition
I, II, V, VIII, & XIII
Term
Match the groups of coagulation factors to the correct description:

Removed by absorption with Barium Sulfate
 Definition
II, VII, IX, X
Term
Match the groups of coagulation factors to the correct description:

Contact factors
 Definition
XI, XII, Fletcher, and Fitzgerald
Term
Match the groups of coagulation factors to the correct description:

Affected by Coumadin
 Definition
II, VII, IX, X
Term
Match the groups of coagulation factors to the correct description:

Common path factors
 Definition
I, II, V, X
Term
Match the factor deficiencies with the features:

Normal PT
Normal PTT
 Definition
Factor XIII Deficiency
Term
Match the factor deficiencies with the features:

Normal PT
Increased PTT
 Definition
Factor IX Deficiency
Factor XII Deficiency
Term
Match the factor deficiencies with the features:

Increased PT
Increased PTT
 Definition
Factor I Deficiency
Factor X Deficiency
Term
Match the factor deficiencies with the features:

Increased PT
Normal PTT
 Definition
Factor VII Deficiency
Term
Match the factor deficiencies with the features:

Causes thrombosis, but NOT bleeding
 Definition
Factor XII Deficiency
Term
Match the factor deficiencies with the features:

Measure with urea solubility
 Definition
Factor XIII Deficiency
Term
Match the factor deficiencies with the features:

Hemophilia B (Christmas Disease)
 Definition
Factor IX Deficiency
Term
Match the factor deficiencies with the features:

Measure by Thrombin Time
 Definition
Factor I Deficiency
Term
Match the factor deficiencies with the features:

Treat with Cryoprecipitate
 Definition
Factor I Deficiency
Factor XIII Deficiency
Term
Why does the liver cause bleeding?
 Definition
Most plasma coagulation factors are produced in the liver so if the liver is diseased, production is reduced. If production is reduced, coagulation tests will be prolonged.
Term
Which factor may be normal or elevated in liver disease? Why?
 Definition
Factor VIII
It is partially produced by vessel endothelial cells and is an acute phase reactant. It may be normal or elevated in liver disease.
Term
What is the purpose of the trypsin inhibitor used in FSP or FDP slide agglutination tests?
 Definition
Trypsin is an antifibrinolytic agent so it prevents in VITRO fibrinolysis. This allows the test to detect only in VIVO fibrinolysis that occurred in the patient's blood prior to collection.
Term
What is the diagnosis if a patient has a POSITIVE FSP and a NORMAL/NEGATIVE D-Dimer?
 Definition
Primary Fibrinogenolysis
Term
What is the diagnosis if a patient has a POSITIVE FSP and a POSITIVE/INCREASED D-Dimer?
 Definition
DIC
Term
List the factors unique to the EXTRINSIC System
 Definition
III
VII
Term
List the factors unique to the INTRINSIC System
 Definition
VIII
IX
XI
XII
Term
What is the therapeutic range for INR for most patients on Coumadin?
 Definition
2.0-3.0
Term
What is the therapeutic range for INR for mechanical heart valves?
 Definition
2.5-3.5
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