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Hematology For Boards III
Hematology For Boards III
53
Medical
Professional
10/26/2006

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Term
High risk for thromboembolism in a pre-surgical pt includes the following 3 items.
Definition
1 - VTE within 3 months, 2 - history of VTE and mechanical mitral valve, 3 - ball/cage valve
Term
Low-risk for thromboembolism in presurgical pt = ? (3)
Definition
No VTE in 3 months; AF without h/o stroke; bileaflet mechanical aortic valve
Term
onset in early childhood is heralded by lymphadenopathy, hepatosplenomegaly, and autoimmune phenomena including hemolytic anemia, thrombocytopenia, and autoimmune neutropenia, often in combination (ie, Evans syndrome)
Definition
Autoimmune Lymphoproloferative Syndrome (ALPS)
Term
ALPS is caused by inactivations of these two genes.
Definition
Fas and caspases.
Term
Clinical findings in Evans' syndrome.
Definition
AIHA and ITP.
Term
Evans syndrome overlaps with this disease.
Definition
ALPS
Term
Treatment of Evans' Syndrome = ?
Definition
Similar to ITP: prednisone, IVIg, rituxan.
Term
This anti-plt drug causes less perioperative bleeing than ASA?
Definition
abciximab (anti GIIb-IIIa).
Term
Mechanism of clopidogrel = ?
Definition
ADP receptor antagonist.
Term
When should coumadin pts stop tx prior to surgery? ASA?
Definition
Coumadin = 72 hrs (3 days); ASA = 3 days or 7 days (differing opinions).
Term
When should heparin be stopped prior to surgery?
Definition
6 hours.
Term
Plt count for surgery = ?
Definition
50,000
Term
Neurosurgeries have an increased risk of this cx?
Definition
DIC
Term
Aprotinin is a protease inhibitor that inhibits these three parts of the coag system.
Definition
plasmin, kallikrein and fibrinolysin
Term
Aprotinin is NOT good for surgery in this area?
Definition
Middle ear.
Term
DDAVP is used in these three conditions.
Definition
VWF deficiency, mild F VIII deficiency, plt dysfxn.
Term
These drugs are lysine analogs.
Definition
tranexamic acid and aminocaproic acid
Term
Aprotinin reduces mortality in this group.
Definition
CABG pts with hemostatic defect or on ASA or prior sternotomy.
Term
Which has more DVTs, hip or knee surgery?
Definition
Hip
Term
Dose of fondaparinux = ?
Definition
2.5 mg subcut once daily
Term
When is first dose of fondaparinux given in post-surgical pts?
Definition
6-8 hrs post-op. NOT EARLIER!
Term
How long is fondaparinux given for, after surgery for TE prophylaxis?
Definition
7 days, in normal-risk pts.
Term
5 absolute contraindications to thrombolysis = ?
Definition
Hem stroke, intracranial neoplasm, intracranial surgery/trauma within past 2 months, active bleeding, internal bleeding within 6 months.
Term
Tickborne infection which can cause severe t-penia.
Definition
Ehrlichiosis.
Term
Viral infection that can cause severe t-penia.
Definition
Hantavirus.
Term
Catastrophic APLS dx criteria.
Definition
Lupus anticoagulant activity and/or positive tests for antiphospholipid antibodies PLUS: 1) involvement of three or more organs 2) development of manifestations in a week or less 3) confirmation of histopathology of small vessel occlusion in at least one organ (usually skin)
Term
Tx of c-APLS = ?
Definition
full-dose heparin
Term
Plt x-fusion threshold = 50k in each of these clinical situations. (3)
Definition
1) path bleeding; 2) DIC; 3) exposure to plt inhibitor
Term
preferred treatment for PTLD and lymphoma occurring <1 year from transplant?
Definition
w/d immunosuppression
Term
These two factors would lead you to treat PTLD with chemotx.
Definition
1) EBV-pos 2) > 1 year post-x-plant
Term
How is CHOP chemo modified in post-transplant pts?
Definition
lowered dose and/or aggressive supportive care
Term
This problem causes worsening of azathiprine toxicity.
Definition
Renal failure (common in x-plant pts).
Term
Toxic metabolite of azathioprine.
Definition
6-mercaptopurine
Term
Allopurinol plus any of these four drugs is a no-no.
Definition
6-MP, azathioprine, septra, ACE inhibitors.
Term
This post-transplant immunosuppressive drug can cause TTP.
Definition
cyclosporine (3% of renal x-plant pts).
Term
Tx for CSA-induced TTP after x-plant = ?
Definition
(Reduce or eliminate CSA. No plasmapheresis is necessary.)
Term
Tx for microcytic/hypochromic anemia in pregnant woman with known iron overload status = ?
Definition
R/o other causes, DO NOT GIVE IRON!
Term
HELLP occurs after which week of pregnancy.
Definition
27th
Term
Two helpful lab findings in AFLP.
Definition
hyperuricemia and hypoglycemia
Term
How is DDAVP best used during pregnancy?
Definition
NOT AT ALL! It causes uterine contractions. (It can be used for postpartum hemmorrhage.)
Term
Which thrombophilia has highest odds ratio for fetal loss?
Definition
Protein S deficiency.
Term
Tx for women who are homozygotes for MTHFR?
Definition
folate
Term
Two conditions for which anticoagulant tx during pregnancy is "urged" = ?
Definition
APL syndrome, AT-III deficiency
Term
How long should UFH be held before delivery?
Definition
12 h
Term
This virus is the most common cause of mild t-penia (>80,000).
Definition
HIV
Term
This combo of drugs often causes t-penia.
Definition
Cimetidine and phenytoin.
Term
4 drug-types which often cause leukocytosis.
Definition
corticosteroids, b agonists, lithium and colony-stimulating factors
Term
Triad of Sweet's syndrome = ?
Definition
acute fever, neutrophilia and painful erythematous plaques infiltrated by neutrophils
Term
Effect of isolation, prophylactic antibiotics, special immunizations and immunoglobulin on pts with chronic ANC < 500 = ?
Definition
There does not seem to be any benefit to any of these measures.
Term
Both congenital and cyclic NTP are associated with what kind of infxn?
Definition
Pyogenic infections.
Term
2 diseases which are more common among congenital NTP patients.
Definition
MDS and AML
Term
Likely viral cause of multicentric Castleman's disease = ?
Definition
HHV-8
Term
Tx for MCDz = ?
Definition
ganciclovir
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