Term
| High risk for thromboembolism in a pre-surgical pt includes the following 3 items. |
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Definition
| 1 - VTE within 3 months, 2 - history of VTE and mechanical mitral valve, 3 - ball/cage valve |
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Term
| Low-risk for thromboembolism in presurgical pt = ? (3) |
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Definition
| No VTE in 3 months; AF without h/o stroke; bileaflet mechanical aortic valve |
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Term
| onset in early childhood is heralded by lymphadenopathy, hepatosplenomegaly, and autoimmune phenomena including hemolytic anemia, thrombocytopenia, and autoimmune neutropenia, often in combination (ie, Evans syndrome) |
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Definition
| Autoimmune Lymphoproloferative Syndrome (ALPS) |
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Term
| ALPS is caused by inactivations of these two genes. |
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Definition
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Term
| Clinical findings in Evans' syndrome. |
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Definition
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Term
| Evans syndrome overlaps with this disease. |
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Definition
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Term
| Treatment of Evans' Syndrome = ? |
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Definition
| Similar to ITP: prednisone, IVIg, rituxan. |
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Term
| This anti-plt drug causes less perioperative bleeing than ASA? |
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Definition
| abciximab (anti GIIb-IIIa). |
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|
Term
| Mechanism of clopidogrel = ? |
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Definition
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Term
| When should coumadin pts stop tx prior to surgery? ASA? |
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Definition
| Coumadin = 72 hrs (3 days); ASA = 3 days or 7 days (differing opinions). |
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Term
| When should heparin be stopped prior to surgery? |
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Definition
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|
Term
| Plt count for surgery = ? |
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Definition
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Term
| Neurosurgeries have an increased risk of this cx? |
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Definition
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Term
| Aprotinin is a protease inhibitor that inhibits these three parts of the coag system. |
|
Definition
| plasmin, kallikrein and fibrinolysin |
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|
Term
| Aprotinin is NOT good for surgery in this area? |
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Definition
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Term
| DDAVP is used in these three conditions. |
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Definition
| VWF deficiency, mild F VIII deficiency, plt dysfxn. |
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Term
| These drugs are lysine analogs. |
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Definition
| tranexamic acid and aminocaproic acid |
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|
Term
| Aprotinin reduces mortality in this group. |
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Definition
| CABG pts with hemostatic defect or on ASA or prior sternotomy. |
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|
Term
| Which has more DVTs, hip or knee surgery? |
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Definition
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Term
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Definition
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Term
| When is first dose of fondaparinux given in post-surgical pts? |
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Definition
| 6-8 hrs post-op. NOT EARLIER! |
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|
Term
| How long is fondaparinux given for, after surgery for TE prophylaxis? |
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Definition
| 7 days, in normal-risk pts. |
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|
Term
| 5 absolute contraindications to thrombolysis = ? |
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Definition
| Hem stroke, intracranial neoplasm, intracranial surgery/trauma within past 2 months, active bleeding, internal bleeding within 6 months. |
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|
Term
| Tickborne infection which can cause severe t-penia. |
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Definition
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|
Term
| Viral infection that can cause severe t-penia. |
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Definition
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Term
| Catastrophic APLS dx criteria. |
|
Definition
| Lupus anticoagulant activity and/or positive tests for antiphospholipid antibodies PLUS: 1) involvement of three or more organs 2) development of manifestations in a week or less 3) confirmation of histopathology of small vessel occlusion in at least one organ (usually skin) |
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Term
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Definition
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|
Term
| Plt x-fusion threshold = 50k in each of these clinical situations. (3) |
|
Definition
| 1) path bleeding; 2) DIC; 3) exposure to plt inhibitor |
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|
Term
| preferred treatment for PTLD and lymphoma occurring <1 year from transplant? |
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Definition
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|
Term
| These two factors would lead you to treat PTLD with chemotx. |
|
Definition
| 1) EBV-pos 2) > 1 year post-x-plant |
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|
Term
| How is CHOP chemo modified in post-transplant pts? |
|
Definition
| lowered dose and/or aggressive supportive care |
|
|
Term
| This problem causes worsening of azathiprine toxicity. |
|
Definition
| Renal failure (common in x-plant pts). |
|
|
Term
| Toxic metabolite of azathioprine. |
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Definition
|
|
Term
| Allopurinol plus any of these four drugs is a no-no. |
|
Definition
| 6-MP, azathioprine, septra, ACE inhibitors. |
|
|
Term
| This post-transplant immunosuppressive drug can cause TTP. |
|
Definition
| cyclosporine (3% of renal x-plant pts). |
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|
Term
| Tx for CSA-induced TTP after x-plant = ? |
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Definition
| (Reduce or eliminate CSA. No plasmapheresis is necessary.) |
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|
Term
| Tx for microcytic/hypochromic anemia in pregnant woman with known iron overload status = ? |
|
Definition
| R/o other causes, DO NOT GIVE IRON! |
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|
Term
| HELLP occurs after which week of pregnancy. |
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Definition
|
|
Term
| Two helpful lab findings in AFLP. |
|
Definition
| hyperuricemia and hypoglycemia |
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|
Term
| How is DDAVP best used during pregnancy? |
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Definition
| NOT AT ALL! It causes uterine contractions. (It can be used for postpartum hemmorrhage.) |
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|
Term
| Which thrombophilia has highest odds ratio for fetal loss? |
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Definition
|
|
Term
| Tx for women who are homozygotes for MTHFR? |
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Definition
|
|
Term
| Two conditions for which anticoagulant tx during pregnancy is "urged" = ? |
|
Definition
| APL syndrome, AT-III deficiency |
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|
Term
| How long should UFH be held before delivery? |
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Definition
|
|
Term
| This virus is the most common cause of mild t-penia (>80,000). |
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Definition
|
|
Term
| This combo of drugs often causes t-penia. |
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Definition
| Cimetidine and phenytoin. |
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|
Term
| 4 drug-types which often cause leukocytosis. |
|
Definition
| corticosteroids, b agonists, lithium and colony-stimulating factors |
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|
Term
| Triad of Sweet's syndrome = ? |
|
Definition
| acute fever, neutrophilia and painful erythematous plaques infiltrated by neutrophils |
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|
Term
| Effect of isolation, prophylactic antibiotics, special immunizations and immunoglobulin on pts with chronic ANC < 500 = ? |
|
Definition
| There does not seem to be any benefit to any of these measures. |
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|
Term
| Both congenital and cyclic NTP are associated with what kind of infxn? |
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Definition
|
|
Term
| 2 diseases which are more common among congenital NTP patients. |
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Definition
|
|
Term
| Likely viral cause of multicentric Castleman's disease = ? |
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Definition
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Term
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Definition
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