Term
| The system through which coagulation factors interact to eventually form a fibrin clot |
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Definition
|
|
Term
| The purpose of the fibrin clot formation is to |
|
Definition
| reinforce the platelet plug |
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Term
|
Definition
|
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Term
|
Definition
|
|
Term
T or F:
ALL Plasma coagulation factors are proteins |
|
Definition
False
Exception is Factor IV - Calcium |
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|
Term
T or F:
Most Plasma coagulation factors are produced in the liver |
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Definition
|
|
Term
| Vitamin K group - Factors are (4) |
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Definition
|
|
Term
| Vitamin K acts as a ____ for the last stage of production of these factors |
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Definition
|
|
Term
| If Vitamin K is deficient from diet or destroyed in the gut flora, factors ___ ___ ___ properly |
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Definition
|
|
Term
| In a Vitamin K Deficiency ___ is present but not ____ |
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Definition
|
|
Term
| Consumable group - Factors are (4) |
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Definition
|
|
Term
| Consumable group Factors are bound in the |
|
Definition
|
|
Term
T or F:
Consumable group factors are consumed during coagulation |
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Definition
|
|
Term
| Are Consumable group factors present in the serum? |
|
Definition
|
|
Term
| Which Factors are labile in the plasma? |
|
Definition
|
|
Term
| Factors XI, XII plus Prekalikrein and HMWK are part of what group? |
|
Definition
|
|
Term
| What does the contact group initiate? |
|
Definition
coagulation
fibrinolysis
inflammation |
|
|
Term
| How are the contact group activated? |
|
Definition
| by contact with collagen and basement membranes of subendothelial tissue |
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|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Tissue thromboplastin (tissue factor) |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Labile Factor (proaccelerin) |
|
Definition
|
|
Term
| Stable factor (serum prothrombin conversion accelerator) |
|
Definition
|
|
Term
| Anti-hemolytic factor (AHF) |
|
Definition
|
|
Term
| Christmas Factor (Plasma thromboplastin component) |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Plasma thromboplastin antecedent |
|
Definition
|
|
Term
| Hageman factor (conatact factor) |
|
Definition
|
|
Term
| Fibrin stabilizing factor |
|
Definition
|
|
Term
| High molecular weight kininogen |
|
Definition
|
|
Term
|
Definition
|
|
Term
| The process of blood coagulation involves a series of biochemical reactions that transforms circulating blood into an insoluble gel through conversion of soluble fibrinogen to fibrin |
|
Definition
| Coagulation Cascade Theory |
|
|
Term
| Once the cascade starts, each factor acts as a ____ and then as a ___ ___ |
|
Definition
substrate
proteolytic enzyme |
|
|
Term
| Intrinsic pathway requires (4) |
|
Definition
Collagen
Calcium
PF3 phospholipid from the PLT
Factor XII is first activated |
|
|
Term
| Which factor needs to be activated first for the Intrinsic pathway to occur? |
|
Definition
|
|
Term
| Extrinsic pathway requires(2) |
|
Definition
Calcium
Tissue thromboplastin to activate factor VII |
|
|
Term
| ____ is the cofactor for both pathways |
|
Definition
|
|
Term
| Common pathway is which factors |
|
Definition
|
|
Term
| Factors ___ to ___ cause factor ____ to go to thrombin |
|
Definition
|
|
Term
| Factor ___ makes fibrin insoluble |
|
Definition
|
|
Term
| The end result of activation of either the intrinsic or extrinsic pathway is the generation of _____ |
|
Definition
|
|
Term
| Thrombin converts what to what? |
|
Definition
| soluble fibrinogen to insoluble fibrin |
|
|
Term
T or F:
Fibrin comprises the fibrin-clot |
|
Definition
|
|
Term
| Has a central role in the bioregulation of hemostasis in both normal and pathologic conditions |
|
Definition
|
|
Term
Converts Fibrinogen to fibrin
Activates factor XIII
Enhances activity of factors V and VIII
Induces platelet aggregation
Plasminogen is converted to plasmin |
|
Definition
|
|
Term
| Thrombin is a ____ _____ that cleaves bond on the ___ ___ |
|
Definition
proteolytic enzyme
fibrinogen molecule |
|
|
Term
| Fibrin monomers now polymerize by _____ bonding to form a ____ clot |
|
Definition
|
|
Term
| Fibrin now covers the platelet plug to make it _____ and ___ ___ blood from escaping from the vessel |
|
Definition
|
|
Term
| Factor XII will also activate the ___ ___ and _______ |
|
Definition
|
|
Term
|
Definition
|
|
Term
Aid in vasoconstriction
lowers blood pressure
produces local pain
increases capillary permeability that aids in inflammation |
|
Definition
|
|
Term
| ______ migrate to area of inflammation |
|
Definition
|
|
Term
| Process of destroying the clot starts as soon as the ___ ___ |
|
Definition
|
|
Term
| Factor XII and vessel partially activate _____ |
|
Definition
|
|
Term
|
Definition
| Prevention of Too Much Clotting |
|
|
Term
| 6 Inhibitors that help to prevent too much clotting |
|
Definition
Blood flow
Anti-thrombin III
Alpha 1 antitrypsin
Alpha 2 macroglobulin
Protein C
Protein S |
|
|
Term
| ____ clears activated proteins |
|
Definition
|
|
Term
| Clotting occurs only on the ___ ___ |
|
Definition
|
|
Term
T or F:
The rest of the blood is unaffected by clotting on the platelet surface |
|
Definition
|
|
Term
Protein C and S:
These proteins degrades factors __ and ___ through interaction with a vessel substance called ____ as well as ____ |
|
Definition
V
VIII
Thrombomodulin
Thrombin |
|
|
Term
|
Definition
|
|
Term
| Which part of Factor VIII is large? |
|
Definition
|
|
Term
| Which part of Factor VIII is small? |
|
Definition
|
|
Term
Produced by endothelial cells and megakaryocytes
Responsible for platelet adhesion
Controlled by autosomal inheritance |
|
Definition
|
|
Term
Produced by the liver
Used in the intrinsic pathway
Controlled by sex-linked inheritance |
|
Definition
|
|
Term
| ____ stimulated the production of VIII:C |
|
Definition
|
|
Term
| If vWF is low or absent, VIII:C is also low, this is observed in |
|
Definition
|
|
Term
T or F:
Fibrin can be formed by two pathways that activate fibrinogen to fibrin |
|
Definition
|
|
