Term
| Microangiopathic Hemolytic Anemia |
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Definition
| Hemolytic process caused by microcirculatory lesions which cause damage to endothelial lining of the small vessels and deposition of platelets and fibrin in microvasculature |
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Term
| Thrombotic thrombocytopenic purpura (TTP) affects |
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Definition
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Term
| Hemolytic uremic syndrome (HUS) affects |
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Definition
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Term
| Complications of pregnancy affects |
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Definition
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Term
| General morphology for MAHA |
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Definition
| Schistocytes, microspherocytes, ↑ retics |
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Term
| Hematologic values associated with MAHA |
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Definition
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Term
| Characteristic erythrocyte morphology of MAHA |
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Definition
| Schistocytes, microspherocytes, ↑ retics, helmet cells |
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Term
| Organisms that can cause erythrocyte hemolysis |
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Definition
| malarial parasites, Babesiosis protozoan, Bees, wasps, spiders, scorpion’s venom |
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Term
| General pathophysiology for MAHA |
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Definition
| Hemolytic process caused by microcirculatory lesions due to damage to endothelial lining of the small vessels and deposition of platelets and fibrin in microvasculature. Thrombus formation within the blood vessels causes RBC forced through fibrin strands in thrombus and fragmented by the force of flowing blood |
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Term
| HUS clinical findings for D+ |
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Definition
| acute onset (Sudden pallor, abdominal pain, vomiting, Bloody diarrhea, macroscopic hematuria), Most serious complication is acute renal failure or chronic renal insufficiency, CNS symptoms are not very severe but possibly present |
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Term
| HUS clinical findings for D- |
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Definition
| reoccring disease, assocaited with various disease |
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Term
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Definition
| recovery, supporitve therapy, control of electrolyte and water imbalances, Mabs agaisnt shiga toxin |
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Term
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Definition
| close observation, blood transfusion, plasma exchange |
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Term
| HUS characteristic findings for eryrocytes |
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Definition
| low hemoglobin, polychromasia, nRBCS, leukocytes shift to left, |
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Term
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Definition
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Term
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Definition
| normal or slightly abnormal |
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Term
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Definition
| thrombocytopenia, severe CNS symptoms, slight renal involvement, fever, anemia |
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Term
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Definition
| plasma exchange with fresh frozen plasma, cyrosupernatant, drug treatment |
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Term
| TTP characteristic findings for eryrocytes |
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Definition
| schistocytes ,low hemoglobin, immature leukocytes, |
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Term
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Definition
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Term
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Definition
| normal or slight prolonged |
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Term
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Definition
| bleeding, organ failure, consumption of coagulase proteins |
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Term
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Definition
| RBC and platelet transfusions, FFP, factor concentrates, treatment of underlying disorder |
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Term
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Definition
| findings for eryrocytes: Thrombocytopenia and schistocytes |
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Term
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Definition
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Term
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Definition
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Term
| Exercise induced hemoglobinuria |
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Definition
| transient hemolysis due to traumatic disruption of the RBC membrane, associated with strenuous exercise, anemia is absent, |
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Term
| Plasmodium parasites (malaria) |
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Definition
| Extravascular destruction of parasitized erythrocytes |
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Term
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Definition
| Extravascular hemolysis due to Protozoan intracellular infection |
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