Term
| birbeck granules (tennis rackets) |
|
Definition
|
|
Term
|
Definition
|
|
Term
| cels are immature and do not stimulate T cells |
|
Definition
|
|
Term
|
Definition
| liver dx, abetalipoproteinemia |
|
|
Term
|
Definition
| thalassemia, anemia of chronic disease, iron deficiency, lead poisoning |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| megaloblastic, marrow failure |
|
|
Term
|
Definition
|
|
Term
|
Definition
| DIC, TTP, HUS, traumatic hemolysis |
|
|
Term
|
Definition
| hereditary spherocytosis, autoimmune hemolysis |
|
|
Term
|
Definition
|
|
Term
|
Definition
| thalassemia, HbC dx, asplenia, liver dx |
|
|
Term
|
Definition
| G6Pd deficiency; iron oxidation -> denatured Hb |
|
|
Term
|
Definition
| nuclear remnants; asplenia |
|
|
Term
| ferrochelatase and ALA dehydratase |
|
Definition
|
|
Term
|
Definition
|
|
Term
| microcytic anemia, HA, memorry loss, demyelination |
|
Definition
|
|
Term
| prophobilinogen deaminase |
|
Definition
| acute intermittent porphyria |
|
|
Term
| painful abdomen, polyneuropathy, psych disturbances, red wind colored urine |
|
Definition
| acute intermittent porphyria |
|
|
Term
| uroporphyrinogen decarboxylase |
|
Definition
|
|
Term
| blistering photosensitivity |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| PT vs PTT: vit K deficiency |
|
Definition
|
|
Term
| types of hereditary thrombosis |
|
Definition
| factor 5 leiden, prothrombin gene mutation, antithrombin deficiency, protein C and S deficiency |
|
|
Term
| most common cause of inherited hypergoaculability |
|
Definition
|
|
Term
|
Definition
|
|
Term
| appropriate absolute polycythemia labs |
|
Definition
| increased RBC mass, decreased o2 sat |
|
|
Term
| causes of appropriate absolute polycythemia |
|
Definition
| lung dx, congenital heart disease, high altitude |
|
|
Term
| inappropriate absolute polycythemia labs |
|
Definition
|
|
Term
| causes of inappropriate absolute polycythemia |
|
Definition
| RCC, wilm's, HCC, hydronephrosis, increased EPO |
|
|
Term
|
Definition
| increased plasma volume, super increased RBC mass |
|
|
Term
| causes of iron deficiency anemia |
|
Definition
| chronic bleeding, malnutrition/absorption disorders, increased demand (pregnancy) |
|
|
Term
|
Definition
| iron deficiency, ACD, thalassemia, lead poisoning, sideroblastic |
|
|
Term
| normocytic nonhemolytic anemias |
|
Definition
| ACD, aplastic anemis, kidney disease |
|
|
Term
| Causes of intrinsic hemolytic anemia |
|
Definition
| hereditary spherocytosis, G6PD, PK, HbC, sickle cell, PNH |
|
|
Term
| extrinsic hemolytic anemia |
|
Definition
| autommune, MIHA, MAHA, infections |
|
|
Term
|
Definition
| folate, B12, orotic aciduria |
|
|
Term
| nonmegaloblastic macrocytic anemias |
|
Definition
| liver disease, alcoholism, reticulocytosis, metabolic disorders, drugs |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| asymptomatic, increased HbA2 |
|
|
Term
|
Definition
| severe anemia, marrow expansion (crew cut, chipmunk facies |
|
|
Term
|
Definition
|
|
Term
| symptoms of lead poisoning |
|
Definition
| lead lines, encephalopathy, erythrocyte basophilic stippling, abdominal colic, sideroblastic anemia, wrist and foot drop |
|
|
Term
|
Definition
| inhibits ferrochelatase and ALA dehydratase |
|
|
Term
| tx of adult lead poisoning |
|
Definition
|
|
Term
| tx of child lead poisoning |
|
Definition
| EDTA, dimercaprol, succimer |
|
|
Term
| causes of sideroblastic anemia |
|
Definition
| X-linked defect in ALA synthase; alcohol, lead |
|
|
Term
|
Definition
|
|
Term
| hypersegmented neutrophils |
|
Definition
| folate and b12 deficiency |
|
|
Term
| causes of folate deficiency |
|
Definition
| malnutrition, malabsorption, impaired metabolism, increased requirement |
|
|
Term
|
Definition
| insufficient intake, malabsorption, pernicious anemia, fish tapeworm |
|
|
Term
| neuro symptoms in B12 deficiency |
|
Definition
| peripheral neuropathy, posterior columns, lateral corticospinal and dementia |
|
|
Term
| drugs that can cause macrocytic anemias |
|
Definition
|
|
Term
| decreased haptoglobin, increased LDH, hemoglobin in urine |
|
Definition
|
|
Term
| caused by aortic stenosis or prosthetic valves |
|
Definition
|
|
Term
| increased LDH plus jaundice |
|
Definition
|
|
Term
| macrophages cleared in spleen |
|
Definition
|
|
Term
dec: iron, TIBC
inc: ferritin |
|
Definition
|
|
Term
dec: iron, ferritin
inc: TIBC |
|
Definition
|
|
Term
| pancytopenia with hypo cellular bone marrow |
|
Definition
|
|
Term
| causes of aplastic anemia |
|
Definition
| radiation, drugs, viral agents, fanconi's, idiopathic |
|
|
Term
| cause of anemia in kidney disease |
|
Definition
|
|
Term
| defect in spctrin, ankyrin, band 3 |
|
Definition
|
|
Term
|
Definition
|
|
Term
| splenomegaly, aplastic anemia |
|
Definition
|
|
Term
| hereditary spherocytosis tx |
|
Definition
|
|
Term
| increased susceptibility to oxidant stress |
|
Definition
|
|
Term
| decreased glutathione, Heinze bodies |
|
Definition
|
|
Term
|
Definition
| pyruvate kinase deficiency |
|
|
Term
|
Definition
|
|
Term
| increased complement mediated hemolysis |
|
Definition
|
|
Term
| increased urine hemosiderin |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| complications of sickle cell |
|
Definition
| aplastic crisis, autosplenectomy, salmonella osteomyelitis, painful crisis, renal papillary necrosis, microhematuria |
|
|
Term
|
Definition
|
|
Term
|
Definition
| IgG; CLL, SLE or alpha-methyldopa |
|
|
Term
|
Definition
| IgM, CLL, mycoplasma, EBV |
|
|
Term
|
Definition
| Ig added to patients RBCs |
|
|
Term
|
Definition
| RBC added to patients serum |
|
|
Term
|
Definition
| DIC, TTP, HUS, SLE and malignant HTN |
|
|
Term
|
Definition
| prosthetic heart valves, and aortic stenosis |
|
|
Term
| infectious causes of extrinsic anemia |
|
Definition
|
|
Term
inc: iron, ferritin
dec: TIBC |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| neuro, renal, fever, thrombocytopenia, microangiopathic hemolytic anemia |
|
|
Term
|
Definition
| hemolysis, uremia, thrombocytopenia |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| sepsis, trauma, obstetric, pancreatitis, malignancy, nephrotic, transfusion |
|
|
Term
|
Definition
| increases Hb and O2 carrying capacity |
|
|
Term
|
Definition
| acute blood loss, severe anemia |
|
|
Term
| effect of platelet infusion |
|
Definition
|
|
Term
| use of platelet transfusion |
|
Definition
|
|
Term
|
Definition
| increased coagulation factor levels |
|
|
Term
|
Definition
| DIC, cirrhosis, warfarin overdose |
|
|
Term
| effect of cryoprecipitate |
|
Definition
| has fibrinogen, factor VIII and XIII |
|
|
Term
|
Definition
| coagulation factor deficiencies |
|
|
Term
|
Definition
leukemia= neoplasm in blood
lymphoma= neoplasm in lymph node |
|
|
Term
| Hodgkins lymphoma vs non-hodgkin |
|
Definition
Hodgkin= RS cells, B symptoms, mediastinal LAD, 50% EBV,
Non-hodgkin= HIV and immunosupression, multiple peripheral nodes, B cells, 20-40 |
|
|
Term
|
Definition
| binucleate, owl's eyes, CD30+ and CD15+ |
|
|
Term
| nodular sclerosing hodgkins |
|
Definition
| most common, increased lymph, collagen banding and lacunar cells |
|
|
Term
|
Definition
|
|
Term
|
Definition
| excellent prognosis, <35 y/o males |
|
|
Term
| Hodgkin lymphoma: lymphocyte depleted |
|
Definition
| poor prognosis, older men with disseminated disease |
|
|
Term
|
Definition
|
|
Term
| endemia vs sporadic burkit |
|
Definition
endemic = africa on jaw
sporadic = pelvis or abdomen |
|
|
Term
| most common non-hodgkin lymphoma |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| cutaneous lesions with HTLV-1 |
|
Definition
|
|
Term
|
Definition
| sezary syndrome/mycoses fungoides |
|
|
Term
| symptoms of multiple myeloma |
|
Definition
| hypercalcemia, renal insufficiency, anemia, and bone lytic lesions/back pain |
|
|
Term
|
Definition
|
|
Term
|
Definition
| RBC stacked like poker chips in multiple myeloma |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| associated with autoimmune hemolytic anemia |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| leukemia that presents as DIC |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| PCV, essential thrombocytosis, myelofibrosis |
|
|
Term
| clone of hematopoietic cells increasingly sensitive to grown factors |
|
Definition
|
|
Term
| fibrotic obliteration of bone marrow -> tear drop cells |
|
Definition
|
|
