Term
| antigen antibody reaction to transfusion of ABO incompatible blood |
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Definition
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Term
| symptoms of hemolytic reaciotn |
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Definition
| fever, chills, nausea, dyspnea, chest pain, back pain, hypotension, hematuria |
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Term
| treatment of hemolytic reaction |
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Definition
stop the transfusion
notify the physician immediatel
be prepared to provide supportive therapy to maiantin heart rate and bp |
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Term
| type 1 hypersensitivity reaction to plasma proteins |
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Definition
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Term
| symptoms of anaphylactic reaction |
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Definition
| urticaria, wheezing, dyspnea, hypotension |
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Term
| anaphylactic reacion occurs within _ of starting infusion |
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Definition
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Term
| treatment for anaphylactic reation |
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Definition
stop the transfusion
notify the physician immediately
be prepared to administer epinephrine and steroids |
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Term
| recipent's antibodies react to dono leukocytes |
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Definition
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Term
| symptoms of febrile reactions |
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Definition
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Term
| rebrile reaction occurs within _ of starting transfusion |
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Definition
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Term
| treatment for febril reaction |
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Definition
stop the transfusion
notify the physician |
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Term
| patent's cardiovascular sytem is unable to manage the additional fluid load |
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Definition
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Term
| symptoms of ciculatory overload |
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Definition
| cough, frothy sputum, cyanosis, decreased blood pressure |
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Term
| treatment for circulatory overload |
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Definition
stop the transfusion
call for help
be preapred to administer oxyghen and/or furosemid |
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Term
| reaction occurs in patients previousl treated with red blood cell tranfusions and alloimmunized so that patient's own immune system attacks transfused RBCs |
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Definition
| delyaed hemolytic reaction |
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Term
| symptoms of delayed hemolytic reactions |
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Definition
| unexplained fever, unecplained decrease in hemoglobin an dhematocrit |
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Term
| delayed hemolytic reaction occures _ after transfusion |
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Definition
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Term
| erythropoietic growht factors |
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Definition
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Term
| stimulates bone marrow to produce red blood cells |
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Definition
| erythropoietic growth factors |
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Term
| sied effects of erythropoietic growth factors |
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Definition
| hypertension, headache, arthralgia, risk of cardiac arrest, heart failure, stroke and MI, especially if given wwhen hgb approaches 11 g/dL or when hgb rises to rapidly |
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Term
| nursing interventions for erythropietic growth factors |
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Definition
| usually adminsitered subq, can be given iv, treated 3 times a week with apoetin alfa or once weekly with darbapoetin alfa until the hct is 30-33 |
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Term
| thrombopoieitc growht factor |
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Definition
| oprelvekin, romiplostim, eltrombopag, plerixafor, leukopoietic growth factors |
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Term
| stimulates bone marrow to produce plateltes |
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Definition
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Term
| used to minimize patelt deficiency in patients on certain chemotherapy drugs |
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Definition
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Term
| side effects of oprelveki (neurmega) |
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Definition
| retention of water and sodium, dysrhthmias, sever allergic reaction, visual disturbances, dizziness, insomina, dyspnea, oral candidiasis |
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Term
| oprelvekin is given by suba injection once a day fro up to _ |
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Definition
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Term
| observe for signs of allergic reaction when taking oprelvekin which are |
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Definition
| rash, urticarial, flushing, fever, hypotension, chest pain, wheezing, dyspnea, edema of the face and tongue |
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Term
| increase platelet prduction in patients with idopathic thrombocytopenic purpura |
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Definition
romiplostim (nplate)
eltrombopag (promacta) |
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Term
| side effects of romiplostim and eltrombopag |
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Definition
althralgia, dizziness, insomina, pain in abdomen, shoulders and extremities
uncommon but serious bone marro fibrosis, hematologic malignancy, thrombembolic events, eltrombopag, hepatotoxic |
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Term
| nursing interventions of romiplostim and eltrombopag |
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Definition
wekkly subq injections with dosage based on platelet count for romiplostim, discontinued if platelets exceed 400 x 10^9
Eltrombopag: PO and rarely used |
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Term
| increases HSCs before bone marrow ablation in non hodgkin lymphoma and multiple myeloma |
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Definition
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Term
| side effects of plerixafor (mozobil) |
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Definition
| injection site reactions, diarrhea, nausea, dizzinesses |
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Term
| nursing interventions for plerixafor |
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Definition
| subq, given on specific schedule r/t HSC harvest, dosage reduced in patients iwth reduced renal function |
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Term
| leukopoietic growth factors |
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Definition
| figrastim, pegfilgrastim, sargramostim |
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Term
| stimulat production of white blodo cells to decrease risk of infection in patients on chemotherapy or having bone marrow transplantation |
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Definition
| leukopoietic growth factors |
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Term
| side effects of leukopoietic growth factors |
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Definition
diarrhea, weakness, rash, malais, bone pain
uncommon pleural and pericardial effusion |
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Term
| nursing interventions for leukopoietic growht factors |
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Definition
| routes and dosages specific to each drugs, schedule based on chemotherpay or bone marrow tranplantation |
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Term
| drugs for deficiency anemias |
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Definition
| oral iron preparations, parenteral iron preparation, oral and parenteral vitamin b12, hydroxyurea |
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Term
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Definition
| ferrous iron salts (feosol, fer in sol, fergon, ferro-sequels) |
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Term
| side effects of oral iron perparations |
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Definition
constipation or diarrhea, black stools, mild nausea, heartburn.
can aggravate peptic ulcers, ucerative colitis, regional enteritis, toxic in larg ammount |
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Term
| nursing interventions for oral iron preparations |
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Definition
| give with food initially then trasisition to between meels for best absorption, give with food only if GI effects are intolerable, if the patient is taking liquid iron dilute the drug and administer it through a straw to prevent stianing the teeth |
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Term
| parenteral iron prparations |
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Definition
| iron dextran (only parenteral form approved for iorn deficiency of all causes) |
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Term
| side effects of parenteral iron preparations |
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Definition
| hypersensitivity reaction, brown skin discoloration at the injection site |
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Term
| nursing intervention for paretneral iron preparation: iron dextran |
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Definition
| test does before starting treatment, IV prefered, give IM injections only in the upper, outer quadrant of the buttock using z track technique |
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Term
| oral and parenteral iron preparation |
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Definition
| vitamin b12 (cyanocobalamin) |
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Term
| intranasal iron preparation |
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Definition
| cyanocobalamin (nascobal) |
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Term
| side effects of vitamin b12 reblacement |
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Definition
| diarrhea, hypokalemia, itching, rash at injection site, rarely heart fialure, anaphylaxis |
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Term
| nursing interventions for oral and parenteral vitamin b12 |
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Definition
| given PO, intranasal, IM or deep subq injection, must be given for rest of the person's life, with intranasal preparation, no hot food for one hour before or after drug administration |
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Term
| use and action of hydroxyurea (droxia) |
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Definition
| prevention of sickle cell crisis |
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Term
| side effects of hydroxyurea |
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Definition
| nausea, vomiting, sever bone marrow supression, contraindicaed during pregnancy |
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Term
| nursing interventsions for hydroxyurea (droxia) |
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Definition
| reinforc to the patietn that this drug must be take regularly to prevent sickle cell crises and is no use once a crisis occurs, monitor blood cell counts frequently |
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