Term
| Describe periph. blood and bone marrow characteristics of megaloblastic anemia |
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Definition
-abnormal marrow RBC precursor
>nuclear maturation/ nuclear/cytoplasmic asynchrony
-decreased retic count
-macrocytic RBCs/ovalocytes(comm. seen w/ dacrocytes)
-hypersegmented neutrophils |
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Term
| Describe causes of Vit. B12 & Folate deficiencies |
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Definition
b12:
-dietary insufficiency
-pernicious anemia-intrinsic factor
-biologic competition
Folate def:
-dietary
-increased need
-malabsorption syndromes
-folate antagonists |
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Term
| explain the lab testing sequence for the megaloblastic anemias |
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Definition
-MCV
-peripheral blood smear
-LDH
-serum vit. levels
-bone marrow exam
-gastric analysis
-schilling test |
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Term
| discuss treatment of megaloblastic anemias |
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Definition
| -reg. monthly intravascular injections of B12 |
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