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Hem/Onc Test 1
Drugs
85
Pharmacology
Graduate
04/15/2012

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Cards

Term
Cyclophosphamide
Definition
Alkylating Agents (Nitrogen Mustard)
PO, IV
Lymphoma, leukemia, solid tumors
Hemorrhagic cystitis, CNS Toxicity
Term
Ifosfamide
Definition
Alkylating Agent (Nitrogen Mustard)
IV
Lymphoma, leukemia, solid tumors
Hemorrhagic cystitis, cardiotoxic
Term
Chlorambucil
Definition
Alkylating Agents (Nitrogen Mustard)
PO
Leukemia, lymphoma
Term
Mechlorethamine
Definition
Alkylating Agents (Nitrogen Mustard)
IV
Leukemia, lymphoma
Term
Bendamustine
Definition
Alkylating Agents (Nitrogen Mustard)
IV
Leukemia, lymphoma
Term
Busulfan
Definition
Alkylating Agents (Alkyl Sulfonates)
IV, PO
Leukemia, lymphoma
Hepatotoxicity
Term
Dacarbazine
Definition
Alkylating Agents (Triazene & Hydrazine)
IV
Leukemia, lymphoma
Term
Procarbazine
Definition
Alkylating Agents (Triazene & Hydrazine)
PO
Leukemia, lymphoma
Term
Cisplatin
Definition
Alkylating Agents (Platinum Coordination Complex)
IV
Solid tumors
Nephrotixicity, Ototoxicity, Peripheral Neuropathy
Term
Carboplatin
Definition
Alkylating Agents (Platinum Coordination Complex)
IV
Solid Tumors
Term
Oxaliplatin
Definition
Alkylating Agents (Platinum Coordination Complex)
IV
Solid Tumors
Peripheral Neuropathy
Term
Methotrexate
Definition
Antimetabolite (Folic Acid Analog)
DHFR Inhibitor
IV
Solid Tumors
Nephrotoxicity (rescued by leucovorin)
Term
Pemetrexed
Definition
Antimetabolite (Folic Acid Analog)
IV
Solid Tumors
Nephrotoxicity
Term
5-FU
Definition
Antimetabolite (Pyrimidine Analog)
Blocks thymidylate synthesis
IV
Solid tumor
Leucovorin enhances activity
Hand-foot syndrome
Term
Capecitabine
Definition
Antimetabolite (Pyrimidine Analog)
Blocks thymidylate synthesis
PO (5-FU prodrug)
Solid tumor
Leucovorin enhances activity
Hand-foot syndrome
Term
Cytarabine
Definition
Antimetabolite (Pyrimidine Analog)
IV
Leukemia
CNS toxicity
Term
Gemcitabine
Definition
Antimetabolite (Pyrimidine Analog)
IV
Solid tumor
Hepatotoxicity
Term
Azacitidine
Definition
Antimetabolite (Pyrimidine Analog)
IV, SC
Leukemia, lymphoma
Term
Decitabine
Definition
Antimetabolite (Pyrimidine Analog)
IV
Leukemia, lymphoma
Term
6-Mercaptopurine
Definition
Antimetabolite (Purine Analog)
PO
Leukemia, lymphoma
Hyperuricemia (alleviated by allopurinol, requires 75% dose reduction)
Term
Fludarabine
Definition
Antimetabolite (Purine Analog)
IV, PO
Leukemia, lymphoma
Autoimmune Effects (hemolytic anemia)
Term
Cladribine
Definition
Antimetabolite (Purine Analog)
IV
Leukemia, Lymphoma
CNS toxicity
Term
Clofarabine
Definition
Antimetabolite (Purine Analog)
IV
Leukemia, lymphoma
Capillary leaks (SIRS)
Term
Nelarabine
Definition
Antimetabolite (Purine Analog)
IV
Leukemia, Lymphoma
Neurotoxicity
Term
Pentostatin
Definition
Antimetabolite (Purine Analog)
IV
Leukemia, Lymphoma
Term
Hydroxyurea
Definition
Antimetabolite (Purine Analog)
Inhibits ribonucleotide reductase
PO
Cutaneous vasculitic toxicity, secondary malignancy
Term
Topotecan
Definition
Topoisomerase I Inhibitor
IV
Solid Tumors
Rapidly hydrolyzed in water
Term
Irinotecan
Definition
Topoisomerase I Inhibitor
IV
Solid Tumor
SN-38 is active form
Diarrhea
Given in polysorbate 80 (hypersensitivity reactions)
Term
Doxorubicin
Definition
Topoisomerase II Inhibitor (Anthracycline)
IV
Solid Tumor, lymphoma, leukemia
Cardiotoxicity (can give dexrazoxane), Vesicant
Term
Doxirubicin Liposomal
Definition
Topoisomerase II Inhibitor (Anthracycline)
IV
Solid Tumor
Less cardiotoxicitity but hand-foot syndrome
Term
Daunorubicin
Definition
Topoisomerase II Inhibitor (Anthracycline)
IV
Leukemia, Lymphoma
Cardiotoxicity (can give dexrazoxane), Vesicant
Red color urine
Term
Idarubicin
Definition
Topoisomerase II Inhibitor (Anthracycline)
IV
Leukemia, lymphoma
Cardiotoxicity (can give dexrazoxane), Vesicant
Term
Epirubicin
Definition
Topoisomerase II Inhibitor (Anthracycline)
IV
Solid Tumor
Cardiotoxicity (can give dexrazoxane), Vesicant
Term
Mitoxantrone
Definition
Topoisomerase II Inhibitor (Anthracycline)
IV
Solid Tumor
Less cardiotoxicity
Term
Etoposide
Definition
Topoisomerase II Inhibitor (Epipdophyllotoxins)
IV (double dose for PO)
Solid tumor
Given in polysorbate 80 (Hypersensitivity)
Term
Teniposie
Definition
Topoisomerase II Inhibitor (Epipdophyllotoxins)
IV
Leukemia, lymphoma, solid tumor
Given in Cremophor LE (more hypersensitivity)
Term
Vincristine
Definition
Antimitotic (Vinca Alkaloid)
Blocks polymerization
IV
Leukemia, lymphoma, solid tumors
Neurotoxicity and vesicant
Term
Vinblastine
Definition
Antimitotic (Vinca Alkaloid)
Blocks polymerization
IV
Leukemia, lymphoma, solid tumors
Vesicant
Term
Vindesine
Definition
Antimitotic (Vinca Alkaloid)
Blocks polymerization
IV
Leukemia, lymphoma, solid tumors
Vesicant
Term
Vinorelbine
Definition
Antimitotic (Vinca Alkaloid)
Blocks polymerization
IV
Solid Tumors
Vesicant
Term
Paclitaxel
Definition
Antimitotic (Taxane)
Promotes polymerization
IV
Solid tumors
Cremophor EL (Hypersensitivity)
Term
Paclitaxel Protein Bound
Definition
Antimitotic (Taxane)
Promotes polymerization
IV
Solid tumors
No hypersensitivity
Term
Docetaxel
Definition
Antimitotic (Taxane)
Promotes polymerization
IV
Solid tumors
Polysorbate 80 (Hypersensitivity)
Term
Cabazitaxel
Definition
Antimitotic (Taxane)
Promotes polymerization
IV
Solid tumors
Cremophor EL (Hypersensitivity)
Term
Ixabepilone
Definition
Antimitotic (Taxane)
Promotes polymerization
IV
Solid tumors
Cremophor El (Hypersensitivity)
Term
Eribulin
Definition
Antimitotic
Blocks polymerization
IV
Solid tumors
Peripheral neuropathy
Term
Estramustine
Definition
Antimitotic
Blocks polymerization
PO
Solid tumor
Cardiotoxicity, estrogen effect, fluid retention
Term
All-trans Retinoic Acid
Definition
Differentiating Agent
Degrades PML-RAR-a
PO
Leukemia
APL differentiation syndrome
Term
Arsenic Trioxide
Definition
Differentiating Agent
Degrades PML-RAR-a
IV
Leukemia
APL Differntiation syndrome, cardiotoxicity
Term
Tamoxifen
Definition
Anti-Hormonal (SERM)
PO
ER positive breast cancer
Increased risk for uterine cancer, hot flashes, decrease bone mineral density
Term
Toremifene
Definition
Anti-Hormonal (SERM)
PO
ER positive breast cancer
Hot flashes
Term
Raloxifene
Definition
Anti-Hormonal (SERM)
PO
ER positive breast cancer
Hot flashes, increased risk for stroke
Term
Fulvestrant
Definition
Anti-Hormonal (SERD)
IM
ER positive breast cancer
Hot flashes
Term
Goserelin
Definition
Anti-Hormonal (LHRH)
SC
Breast, prostate
Decrease bone mineral density, hot flashes
Term
Megestrol
Definition
Anti-Hormonal (LHRH)
Synthetic progesterone
PO
ER positive breast cancer
Hot flashes
Term
Exemestane
Definition
Anti-Hormonal (Aromatase Inhibitor)
PO
ER positive breast cancer
Hot flashes, decreased bone mineral density
Term
Anastrozole
Definition
Anti-Hormonal (Aromatase Inhibitor)
PO
ER positive breast cancer
Decreased bone mineral density, hot flashes
Term
Letrozole
Definition
Anti-Hormonal (Aromatase Inhibitor)
PO
ER positive breast cancer
Decreased bone mineral density, hot flashes
Term
Leuprolide
Definition
Anti-Hormonal (Androgen Deprivation Therapy)
SC
Prostate Cancer
Decreased bone mineral density, tumor flare, hot flash
Term
Triptorelin
Definition
Anti-Hormonal (Androgen Deprivation Therapy)
Prostate
Hypersensitivity reactions
Term
Degarelix
Definition
Anti-Hormonal (Androgen Deprivation Therapy)
LHRH Antagonist, no tumor flare
SC
Hot flashes
Term
Flutamide
Definition
Anti-Hormonal (Androgen Deprivation Therapy)
PO
Prostate
Hepatotoxicity
Term
Bicalutamide
Definition
Anti-Hormonal (Androgen Deprivation Therapy)
PO
Prostate
Term
Nilutamide
Definition
Anti-Hormonal (Androgen Deprivation Therapy)
PO
Prostate
Night blindness
Term
Bortezomib
Definition
Inhibits NFkB by degrading IkB
IV or SC
Myeloma, lymphoma
Peripheral neuropathy
Term
Thalidomide
Definition
MOA unsure
PO
Myeloma
TERATOGEN, DVT, neurotoxicity
Term
Lenalidomide
Definition
MOA unknown
PO
Myeloma
Less toxic than thalidomide but same toxicities
Term
L-Asparaginase
Definition
Cleaves L-asparagine and inhibits protein synthesis
IV, IM
Leukemia
Hypersensitivity, hepatotoxicity, clotting abnormalities, increased TGs, pancreatitis
Term
Bleomycin
Definition
Breaks DNA strands
IV, IM, or SC
Solid tumor, lymphoma
Max 400 units in lifetime due to pulmonary fibrosis
Hypersensitivity
Term
Imatinib
Definition
BCR-ABL Kinase Inhibitor
PO
Ph+ CML
Hepatotoxicity, hemorrhage
Term
Nilotinib
Definition
BCR-ABL Kinase Inhibitor
PO
Ph+ CML
Use when resistant or intolerant to imatinib
Cardiotoxicity, less hemorrhage
Term
Dasatinib
Definition
BCR-ABL Kinase Inhibitor
Ph+ CML
PO
Use when resistant or intolerant to imatinib
Term
Gefitinib
Definition
EGFR Inhibitor
PO
Lung Cancer
Rash
Term
Erlotinib
Definition
EGFR Inhibitor
PO
Lung Cancer
Rash
Term
Lapatinib
Definition
EGFR Inhibitor
PO
Breast Cancer (HER2/Neu)
Rash
Term
Vemurafenib
Definition
BRAFv600E Inhibitor
PO
BRAF positive melanoma
Hypersensitivity, cardiotoxicity, cutaneous squamous cell carcinoma
Term
Crizotinib
Definition
EML4-ALK Inhibitor
PO
Vision impairment, cardiotoxicity
Term
Rituximab
Definition
Anti-CD20, ADCC and CDC
IV
Leukemia, lymphoma
Infusion reactions
Term
Ofatumumab
Definition
IV
Leukemia
Infusion reactions
Term
Alemtuzumab
Definition
Anti-CD52, ADCC and CDC
IV
Leukemia
Infusion reactions and Myelosuppresion
Term
Brentuximab
Definition
Chimeric antibody for CD30
IV
Lymphoma
Neurotoxicity, infusion reactions
Term
Bevacizumab
Definition
Humanized mAb against VEGF
IV
Hemorrhage, poor wound healing
Term
Cetuximab
Definition
Chimeric mAb against EGFR
IV
Infusion reactions
Term
Panitumumab
Definition
Human mAb against EGFR
IV
Pulmonary toxicity
Term
Trastuzumab
Definition
Humanized mAb against HER2/neu
IV
Breast cancer
Cardiotoxicity, do not give with cyclophosphamide, doxorubicin
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