Term
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Definition
•trade name: Prinivil
•therapeutic class: Antihypertensive, treatment of heart failure
•therapeutic use: Treatment of hypertension, heart failure, and improvement of survival in patients when administered within 24 hours after MI
•pharmacologic class: ACE inhibitor
•mechanism of action: Inhibits angiotensin converting enzyme, decreases aldosterone secretion |
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Term
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Definition
•trade name: Lopressor
•therapeutic class: Antihypertensive, beta-blocker
•therapeutic use: To slow progression of HF, & to significantly reduce the long-term consequences of HF
•pharmacologic class: Selective beta1-adrenergic antagonist
•mechanism of action: Decreases cardiac workload by reduction of heart rate (due to selective blockade of beta1-adrenergic receptors) |
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Term
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Definition
•trade name: Primacor
•therapeutic class: Positive inotrope
•therapeutic use: Short-term treatment of advanced HF, to immediately increase myocardial contractility & cardiac output
•pharmacologic class: Phosphodiesterase inhibitor
•mechanism of action: Inhibits degradation of cAMP by phosphodiesterase |
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Term
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Definition
•trade name: Lasix
•therapeutic class: Antihypertensive, treatment of edema & heart failure
•therapeutic use: Treatment of acute heart failure, to remove edema, especially when cardiac output & renal flow are severely diminished
•pharmacologic class: Loop diuretic
•mechanism of action: Prevents renal reabsorption of sodium & chloride in the loop of Henle |
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Term
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Definition
•trade name: Digitek
•therapeutic class: Positive inotrope
•therapeutic use: To increase cardiac output, alleviating symptoms of heart failure & improving exercise tolerance
•pharmacologic class: Cardiac glycoside
•mechanism of action: Inhibits sodium-potassium ATPase, and increases intracellular calcium concentrations in cardiac cells |
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