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G. Smith- Viral Disease
Viral Diseases
74
Pathology
Graduate
10/25/2009

Additional Pathology Flashcards

 


 

Cards

Term
What are ways that Viruses can be transmitted?
Definition

droplet

direct physical contact

indirect physical contact

airborne

fecal-oral

vector

Term
Retroviruses use what enzyme to convert their RNA to DNA?
Definition
reverse transcriptase
Term
What is an abortive infection?
Definition
the virus has an incomplete viral replication cycle
Term
What is a latent infection?
Definition
virus persists but does not replicate or destroy the cell
Term
What is a persistant infection?
Definition
viruses are made continously, with or without altering the cell
Term
What is transformation?
Definition
virus-cell interaction that results in a cell change that can be inherited
Term
What are the respiratory Viral Infections?
Definition

Influenza A, B, C

Rhinovirus

Adenovirus

Coxsackie

Echovirus

Term
What are the enteric Viral Infections?
Definition

Rotavirus

Norwalk

Enteric adenovirus

Term
What are the herpes Viral Infections?
Definition

Herpes Simplex I and II

Cytomegalovirus

Epstein-Barr

Varicella-Zoster

Term
What are the hepatic Viral Infections?
Definition
Hep A, B, C, D, E
Term
What are the nervous system Viral Infections?
Definition

Poliovirus

Rabies

JC virus

Term
What is the slow virus?
Definition
Creutzfeldt-Jakob
Term
What is a subacute sclerosing panencepahilits virus?
Definition

Kuru

 

-a type of transmissible spongiform encephalopathy associated with the cannibalism

Term
What is the main cause for the common cold?
Definition
Rhinovirus
Term
How can your patient become more susceptible to Rhinovirus 14?
Definition

-if they have an ICAM-1 receptor on epithelial cells

-if thier cells have been preexposed to TNF alpha

Term
What is the major cause of influenza infections?
Definition
influenza A
Term
Mutations of hemagglutinin and neuraminidase allow a virus to escape most antibodies causing an epidemic called what?
Definition
antigenic drift
Term
When hemagglutinin and neuraminidase are replaced through recombination of RNA segments with those of animal viruses a pandemic can occur, this is called what?
Definition
antigenic drift
Term
Primary influenza virus infection is cleared by what?
Definition

1. cytotoxic T cells killing infected cells

2. intracellular anti-influenza protein induced in macrophage

Term
What is a non-enveloped icosohedral virus that most commonly is responsible for milder URI outbreaks but can cause severe sporadic pnuemonia?
Definition
Adenovirus
Term
Which virus can survive in the environment for a long time and causes hand-foot and mouth disease?
Definition
Coxsackie
Term
Which virus is among the leading causes of acute febrile illness, is the most common cause of aseptic meningitis, and linked to high infant mortality rates, pharyngitis, and myocarditis?
Definition
Echovirus
Term
Which virus is associated with bronchiolitis and pneumonia in children under 1 yr of age in the US?
Definition
respiratory syncytial
Term
What virus is a coronavirus and affects the lower respiratory tract and then spreads throughout, can cause severe respiratory disease, tachypnea, and pleurisy?
Definition
SARS
Term
What subtype of virus A causes swine flu and avian flu?
Definition
H1N1
Term
Which virus is a major cause of diarrhea in children under the age of six and is a double stranded RNA?
Definition
Rotavirus
Term
Which virus is the second leading cuase of diarrhea in infants and children?
Definition
Enteric adenovirus
Term
Which virus causes gastroenteritis with diarrhea and rarely occurs in children?
Definition
Norwalk virus
Term
Which virus is enteric, found only in the gut,  and has a surface like a star shape?
Definition
Astrovirus
Term
How is HSI and HSII transmitted?
Definition

HSI-orally and respiratory

 

HSII-sexual contact

Term
Which virus cause mononucleosis?
Definition
Epstein-Barr
Term
What virus replicates in the salivary gland epithelial cells and enter the B cells in the lymphoid tissues?
Definition
Epstein-Barr
Term
Which virus can cause two diseases, is highly contagious, and can remain latent in nerve cells?
Definition
Varicella-Zoster
Term
What are the clinical manifestation associated with herpes simplex infections?
Definition

gingivo-stomatis

conjuctivitis/keratitis

Kaposi's Varicelliform

genital herpes

Term

What is

gingivo-stomatis?

Definition
vesicular erruptions extending from around the nose to the mouth and the retropharynx
Term

What is

conjuctivitis/keratitis?

Definition
corneal lesions, infiltrates of mononuclear cells leading to scars, opacification, and blindness
Term

What is

Kaposi's Varicelliform?

Definition
vesiculating involvement of the skin
Term
Which virus is caused by a paramyxovirus, is highly contagious, and shows symptoms of photophobia,eye burning, Kopliks spots, and skin rash?
Definition
measles (rubeola)
Term
what are Kopliks spots?
Definition
white lesions in the mouth associated with measles
Term
Which virus is caused by a paramyxovirus, is highly contagious, and shows symptoms inflammation and swelling of the parotid gland (less often salivary)?
Definition
Mumps
Term
Which virus is a togavirus, characterized by measles like rash ans swelling of cervical lymph nodes, swelling and joint pain, and is a concern for severe congenital malformations?
Definition

Measles

 

(Rubella)

Term
What is Conyloma Acuminatum (benign tumor of the external genitals) caused by?
Definition
HPV
Term
What causes warts, laryngeal growths, and cervical cancer?
Definition
Papovavirus
Term
Which hepatitis does not lead to chronic infection?
Definition
Hep A
Term
What are DANE particles?
Definition
complete hepatitis B virions that can be seen in the liver
Term
What are council bodies?
Definition
inclusion particles associated with viral hepatitis
Term
Which hepatitis is the major cause of liver disease and has no vaccine?
Definition
Hep C
Term
Which hepatitis can only work if Hep B is present?
Definition
Hep D
Term
Which hepatitis is the enterically transmitted?
Definition
Hep E
Term
What characteristics does the early acute phase of HIV have?
Definition

-high level of virus production

-widespread virus in lymph

-sore throat, myalgias, fever, rash

-3 to 6 weeks after infection

Term
What characteristics does the middle chronic phase of HIV have?
Definition

-clinical latency

-intact immune system

-low replication in lymph

Term
What characteristics does the final or crisis phase of HIV have?
Definition

-breakdown of host defense

-long fever, weight loss, diarrhea, and reduced CD4 count

Term
What opportunistic infections go with HIV?
Definition

Herpes Simplex

CMV

EBV

VZ

Hep B

 

Term
What malignatn diseases go with HIV?
Definition

Kaposi's sarcoma

Non-Hodgkin's B cell lymphoma

Undiff. B cell lymphoma

Diffuse large cell lymphoma

Hodgkin's disease

Squamous cell carcinoma

Term
A patient comes in with encephalitis, malaise, and fever. They tell you they were bit by a rabbit a few weeks ago. They then experience convulsions and foaming at the mouth in front of you. You think that they have?
Definition
Rabies
Term
What virus infects the oropharynx first then multiplies in the intestines and lymph nodes, and can invade the CNS affecting motor neurons of the spinal cord or brain stem?
Definition
Polio
Term
What virus is genetically similar to SV40 and cuases multifocal leukoencephalopathy in immunedeficient patients?
Definition
JC virus
Term
What prion disease can cause rapid progressive dementia?
Definition
Creutzfeldt-Jakob
Term
What prion disease is caused by cannibalism and presents with tremors and motor incapacity and death?
Definition
Kuru
Term
What is caused by the measles? It also causes personality changes, involuntary movements, and neurologic deteriorations?
Definition
Subacute Slcerosing Panencephalitis (SSPE)
Term
Which virus is characterized by serous inflammation of the linings of the brain?
Definition
Acute Aseptic Meningitis
Term
which virus is in the RNA virus family Filoviridae?
Definition
Ebola
Term
What does HTLV-1 stand for?
Definition

human T-cell lymphotrophic virus

 

same class as AIDS

Term
DNA probes can be used to detect which infectious agents?
Definition

HIV

HBV

HCV

Term
Culturing can be used to detect which infectious agents?
Definition

CMV

HSV

Term
Antibody probes can be used to detect which infectious agents?
Definition

Coxsackie

EBV

Term
Which influenza is most virulent?
Definition
Influenza A
Term
Which influenza almost exclusively infects humans?
Definition
Influenza B
Term
What are guarenria?
Definition
inlcusion bodies in cells associated with smallpox
Term
What is verruca vulgaris?
Definition
a common wart associated with HPV
Term
HPV causes what type of proliferative lesion?
Definition
squamous
Term
The pathology of infected cells in HPV is a characteristic cytopathic effect termed?
Definition

Koilocytosis

 

-Koilocytes are a type of dysplastic squamous cell found in potentially precancerous cervical lesion 

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