Term
|
Definition
dont retain gram stain
cytoplasmic membrane surrounded by thick peptidoglycan layer
outer membrane contains LPS |
|
|
Term
|
Definition
lipopolysccharide
very important in pathogenesis
lipis and polysaccharides
an endotoxin
o antigen, inner and outer cores
anchored by lipid A to outer cell membrane
elicits strong immune response in host
binds lipid binding protein
complex picked up by cd14, tlr 2 and 4
macrophages release cytokines
blood clotting
MAC
inflammation
can cause DIC or adult respiratory distress syndrome |
|
|
Term
|
Definition
fever
malaise
chills
nausea |
|
|
Term
| meningitis and septicaemia |
|
Definition
neisseria meningitidis
when meningitis gets to CNS it becomes septicaemia
when reaches rest of body becomes invasive meningococcal disease
can also cause pneumonia, septic shock, pericarditis etc
intracellular
capsule
3 processes- colonization, proliferation, survival |
|
|
Term
| meningitis virulence factors |
|
Definition
capsule - antiphagocytic properties
OMPs - outer membrane proteins
porins - A,B
adhesin
OPC - invasin
iron sequestarian mechanisms
exotoxin - LPS
IgA protease |
|
|
Term
|
Definition
gram neg rods
aerobes
oxidase pos
non lactose fermenters
primarily opportunistic |
|
|
Term
|
Definition
in soil and water and man made environments
some intrinsic antibiotic resistance
opportunistic:
-immunocompromised
-burns
indwelling catheter
VAP |
|
|
Term
| non mucoid psudomonads infections |
|
Definition
not associated with rapid lung function decline
not usually MDR
aggressive treatment |
|
|
Term
| chronic pseudomonoads infections |
|
Definition
involves mucoid strains
loads of exopolysaccharide synthesis |
|
|
Term
| psuedomonads burns infections |
|
Definition
burns break down physical barrier that prevents bacteria access
depress local immune system
early colonisation:
-gram pos
gram pos/neg/yeasts
neg usually most common invasive cause |
|
|
Term
|
Definition
ceftazidime
ciprofolxacin
gentamicin |
|
|
