Term
|
Definition
| aggregates of urate crystals in soft tissues |
|
|
Term
|
Definition
| biochemical defect unknown |
|
|
Term
| what does increase in PRPP have on uric acid levels? |
|
Definition
| PRPP activates regulated, committed step in purine de novo synthesis. This leads to more uric acid. |
|
|
Term
|
Definition
| x-linked; less inhibition by purine nucleotides; found in some gout patients |
|
|
Term
| partial deficiency in HGPRT |
|
Definition
| x-linked; increases availability of PRPP for de novo synthesis (since it isn't consumed in salvage) |
|
|
Term
|
Definition
| saturine (secondary) gout; impairment of renal excretion |
|
|
Term
| treatment of gouty inflammation |
|
Definition
| NSAIDs, colchicine, steroidal agents |
|
|
Term
|
Definition
| inhibits microtubule assembly (& therefore phagocytosis of urate crystals by neutrophils) |
|
|
Term
|
Definition
| increase renal excretion of urate |
|
|
Term
| xantine oxidase inhibitors |
|
Definition
| inhibits catalyzation of hypoxanthine to xanthine and xanthine to uric acid |
|
|
Term
|
Definition
| inhibits XO; competitively inhibits oxidation of hypoxanthine |
|
|
Term
|
Definition
| product of allopurinol; analog of xanthine; noncompetitive inhibitor of XO |
|
|
Term
|
Definition
| nonpurine-analog inhibitor of XO; for gout treatment |
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|
