Term
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Definition
Prodrug inhibitor uric acid formation via xanthine oxidase (converted by enzyme it inhibits)
SE: rash, nausea, nephritis, cataracts, hepatoxic
used during tumor lysis syndrome
may precipitate crisis so put on colchicine 1st.
CONTRAINDICATED PROBENECID (increases clearance) |
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Term
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Definition
anti-inflammatory pathopneumonic for gout
inhibits tubulin polymerization:
anti-migration
anti-LTB4 synthiesis
Has a very poor therapeutic index: GI distress and bone marrow supression
effectiveness dose dependent during attacks |
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Term
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Definition
Increases rate of uric acid secretion by blocking proximal tubule resorbtion
May exacerbate attack!
Increased risk of renal stones and should include nsaids due to initial increase attacks
caution with peptic ulcer disease
inhibited by aspirin
additive salicates |
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Term
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Definition
Xanthine Oxidase Inhibitor
TX Gout patients intolerant to allopurinol
SE: Rash, GI upset, cataracts, nephritis, hepatotoxic
Reduces urate level better than allopurinol but no more effective on number of attacks
more cardiotoxic |
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Term
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Definition
COX inhibitors first line for gouty attacks
INFOMETHACIN/NAPROXEN best
NO ASPIRIN/SALICILATE
oxaprozin lowers serum levels and increases possibility stones! |
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Term
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Definition
recombinant porcine uricase converts uric acid to allatoin
given IV
anaphylaxis approx 25%
horrible gout (3% given + Immunodepressants) |
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