Term
| What is Paget disease of the bone? |
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Definition
Paget disease is a "focal" bone disorder (i.e., it is not spread throughout the skeleton, but is isolated as lesions in only parts of bone).
Due to increased activity of osteoclasts, followed by filling in with new, poor quality, bone.
It is common in adults.
Monostotic (involving one bone).
Polyostotic (multiple bones). |
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Term
| Common sites for Paget disease to manifest? |
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Definition
| Pelvis; vertebrae; skull; tibia; femur. |
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Term
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Definition
| Unknown. May be viral or genetic. |
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Term
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Definition
| Bone pain (most common complaint); headache; skeletal deformity; fractures; high-output cardiac failure; nerve compression syndromes. NOTE: Most people are asymptomatic; diagnosis made by increased serum alkaline phosphatase level or on x-ray. |
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Term
| Diagnosis of Paget disease? |
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Definition
| Biochemical markers of bone turnover (serum alkaline phosphatase level); and x-ray abnormalities. |
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Term
| What is one specific complication of Paget disease? |
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Definition
| Osteosarcoma in the pagetic lesion. |
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Term
| What complication(s) can occur if Paget disease occurs around a joint? |
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Definition
| Secondary arthritis and gout. |
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Term
| What are the two major goals of treatment for Paget disease? |
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Definition
| 1: relieve symptoms; 2:prevent complications. |
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Term
| Nonpharmacologic treatment for Paget disease? |
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Definition
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Term
| Pharmacologic treatment for Paget disease? |
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Definition
| 1: Analgesics for pain; 2:Drugs to prevent osteoclast resorption: Bisphosphonates are the mainstay of treatment (they inhibit osteoclast activity). |
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Term
| Name some bisphosphonate drugs used to treat Paget disease. |
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Definition
| alendronate (Fosamax); risedronate (Actonel); pamidronate (Aredia); zoledronate (Zometa); etidronate (Didronel); Tiludronate (Skelid); calcitonin (Miacalcin). |
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