Term
| what period of the day is gluconeogenesis the highest? |
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Definition
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Term
| gluconeogenic mechanisms clear this from muscle and erythrocytes |
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Definition
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Term
| gluconeogenesis removes this from the blood |
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Definition
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Term
| name some of the TCA intermediates retrieved from gluconeogenesis |
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Definition
| citrate, isocistrate, a-ketoglutarate, succinyl CoA, succinate, fumarate and malate via oxidation to oxaloacetate |
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Term
| these two AA are particulary important because they transport amino groups from extra hepatic tissues to the liver |
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Definition
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Term
| these two contribute to the formation of pyruvate |
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Definition
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Term
| these two things contribute to oxaloacetate |
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Definition
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Term
| these two are used to make triose phosphates |
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Definition
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Term
| these two enzymes are NOT gluconeogenic |
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Definition
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Term
this cycle regulates glucose metabolism.
what is it and its functions |
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Definition
| the cori cycle. liver clears lactate from muscle and converts it glucose via glucogenesis. glucose is then shuttled over to the muscle |
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Term
| what are the three irreversible glycolytic reactions |
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Definition
| hexokinase, pfk-1, oxaloacetate |
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Term
| biotin is covalently bound to what? |
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Definition
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Term
| what is the function of biotin? |
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Definition
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Term
| where is pyruvate carboxylase located? |
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Definition
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Term
| where is PEP carboxykinase located? |
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Definition
| cytosol and the mitochondrial matrix |
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Term
| what are the 3 ways in which gluconeogenesis is regulated? |
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Definition
allosteric modification (instantaneous)
hormonal regulation via covalent modification of enzymes (rapid)
Hormonal regulation via control of gene expression (slow) |
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Term
| what allosterically stimulates pyruvate carboxylase |
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Definition
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Term
| what allosterically inhibits pyruvate dehydrogenase? |
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Definition
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